Rare causes of persistent wheeze that mimic poorly controlled asthma

Mokoka, Matshediso Constantia; Ullah, Khalil; Curran, David; O’Connor, Terence M.

doi:10.1136/bcr-2013-201100

Cited by 12 publications

(6 citation statements)

References 12 publications

(7 reference statements)

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“…Patients with iatrogenic LTS tend to have a more even sex distribution and higher rates of comorbidities [4]. Regardless of the etiology, SGS can be misdiagnosed easily as a pulmonary disease such as asthma, and delays in diagnosis and treatment up to 4 years have been reported [7][8][9][10][11]. Given the multiple etiologies and recurrent nature of SGS, management may include repeated surgical intervention and hospital stays, as well as adjuvant therapies.…”

Section: Introductionmentioning

confidence: 99%

An Updated Review of Subglottic Stenosis: Etiology, Evaluation, and Management

2022

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Purpose of ReviewTo assimilate the newly published literature regarding subglottic stenosis (SGS), including basic science and translational research on mechanisms of etiology, clinical diagnostics, and therapeutic treatments. Recent FindingsThe role of inflammation in development of iatrogenic and idiopathic SGS (iSGS) is continuing to be studied. The IL-23/IL-17A inflammatory axis appears to be a potential mechanism for development of iSGS. Additionally, as anticipated in an inflammatory milieu, PD-1/PD-L1 expression is upregulated. If the PD-1/PD-L1 axis is important in SGS pathogenesis, then it may represent a potential target for immunotherapeutic inhibition, given its success in cancer treatment. In terms of surgical management, prospective studies show that endoscopic approaches have more frequent recurrence compared to open techniques. Summary SGS arises from various etiologies, and further understanding of its pathogenesis can aid in the development of novel therapies. It is imperative to obtain a thorough history for each patient presenting with respiratory complaints, as misdiagnosis can delay proper treatment. Endoscopic and open surgical techniques continue to be investigated in a growing number of prospective clinical trials to determine optimal treatment protocols. In-office injections are gaining popularity and show promise in the treatment of SGS.

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Section: Introductionmentioning

confidence: 99%

An Updated Review of Subglottic Stenosis: Etiology, Evaluation, and Management

2022

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“…Differential diagnosis of variable central airway obstruction should include the following: laryngeal polyp, large retrosternal goitre, while differential diagnosis of fixed central airway should include as follows: subglottic stenosis -congenital or acquired (for example after prolongated endotracheal intubation or in the course of autoimmune and inflammatory diseases like granulomatosis with polyangitis), vocal cord dysfunction, vocal cord paralysis, laryngeal web [9,12].…”

Section: Discussionmentioning

confidence: 99%

Sarcoidosis-Associated Pulmonary Hypertension Treated with Sildenafil

Kusak

Cichocka‐Jarosz

Jedynak-Wąsowicz

et al. 2017

Advances in Respiratory Medicine

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Vascular rings are congenital defects of great vessels. They cause compression of the trachea or/and the esophagus and therefore result in symptoms like inspiratory stridor, cough, wheezing, recurrent respiratory tract infections or dysphagia. In some cases, the correct diagnosis can be delayed for many years, especially when vascular rings produce less severe symptoms or symptoms mimicking other diseases (most of all asthma). In this article, we would like to emphasis the usefulness of pulmonary function test (spirometry) in the initial diagnosis of vascular rings in school-aged children, as well as the importance of spirometry in evaluating patients with asthma presumption.

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“…DAA is usually diagnosed in infancy or early childhood, but occasionally the diagnosis is delayed for years. There are several reports of DAA masquerading as long-standing asthma, both in children (14)(15)(16) and in adults (17)(18)(19)(20)(21). Occasionally, DAA may simulate exercise-induced asthma (22,23).…”

Section: Discussionmentioning

confidence: 99%

Ground zero: not asthma at all

Benedictis

Mirabile

et al. 2015

Pediatric Allergy Immunology

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Upper airway obstruction is commonly misdiagnosed as asthma. We report on four children with recurrent respiratory symptoms who had been erroneously diagnosed as having asthma and who received anti-asthma medication for several years. The evaluation of spirometry tracing was neglected in all cases. Subglottic stenosis, tracheomalacia secondary to tracheo-esophageal fistula, double aortic arch, and vocal cord dysfunction were suspected by direct inspection of the flow-volume curves and eventually diagnosed. The value of clinical history and careful evaluation of spirometry tracing in children with persistent respiratory symptoms is critically discussed.

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Rare causes of persistent wheeze that mimic poorly controlled asthma

Cited by 12 publications

References 12 publications

An Updated Review of Subglottic Stenosis: Etiology, Evaluation, and Management

An Updated Review of Subglottic Stenosis: Etiology, Evaluation, and Management

Sarcoidosis-Associated Pulmonary Hypertension Treated with Sildenafil

Ground zero: not asthma at all

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