Ground zero: not asthma at all

Benedictis, Fernando Maria de; Benedictis, Diletta de; Mirabile, Lorenzo; Pozzi, Marco; Guerrieri, Arcangela; Pillo, Sabrina Di

doi:10.1111/pai.12421

Cited by 11 publications

(3 citation statements)

References 38 publications

(47 reference statements)

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“…In cases having a history of wheezing characterized by spirometry anomalies but not responsive to therapy, alternative diagnoses must be considered. A careful examination of the flow–volume curves may indicate subglottic stenosis, tracheomalacia secondary to tracheo‐esophageal fistula, double aortic arch, or vocal cord dysfunction .…”

Section: Diagnosis and Managementmentioning

confidence: 99%

Asthma and allergic rhinitis in childhood: what's new

Mastrorilli

Posa

Cipriani

et al. 2016

Pediatric Allergy Immunology

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Novel approaches are currently offered for the diagnostic workup and therapeutic management of allergic rhinitis and asthma. New predictive biomarkers of allergy and asthma are available. Primary and secondary prevention, earlier intervention, and modification of the natural history of allergic rhinitis and asthma are being intensively investigated. This review highlights advances in the understanding of the etiology, diagnosis, and management of atopic airway diseases in childhood, as well as prenatal and early-life risk factors and strategies for prevention.

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Section: Diagnosis and Managementmentioning

confidence: 99%

Asthma and allergic rhinitis in childhood: what's new

Mastrorilli

Posa

Cipriani

et al. 2016

Pediatric Allergy Immunology

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“…Patients with iatrogenic LTS tend to have a more even sex distribution and higher rates of comorbidities [4]. Regardless of the etiology, SGS can be misdiagnosed easily as a pulmonary disease such as asthma, and delays in diagnosis and treatment up to 4 years have been reported [7][8][9][10][11]. Given the multiple etiologies and recurrent nature of SGS, management may include repeated surgical intervention and hospital stays, as well as adjuvant therapies.…”

Section: Introductionmentioning

confidence: 99%

An Updated Review of Subglottic Stenosis: Etiology, Evaluation, and Management

2022

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Purpose of ReviewTo assimilate the newly published literature regarding subglottic stenosis (SGS), including basic science and translational research on mechanisms of etiology, clinical diagnostics, and therapeutic treatments. Recent FindingsThe role of inflammation in development of iatrogenic and idiopathic SGS (iSGS) is continuing to be studied. The IL-23/IL-17A inflammatory axis appears to be a potential mechanism for development of iSGS. Additionally, as anticipated in an inflammatory milieu, PD-1/PD-L1 expression is upregulated. If the PD-1/PD-L1 axis is important in SGS pathogenesis, then it may represent a potential target for immunotherapeutic inhibition, given its success in cancer treatment. In terms of surgical management, prospective studies show that endoscopic approaches have more frequent recurrence compared to open techniques. Summary SGS arises from various etiologies, and further understanding of its pathogenesis can aid in the development of novel therapies. It is imperative to obtain a thorough history for each patient presenting with respiratory complaints, as misdiagnosis can delay proper treatment. Endoscopic and open surgical techniques continue to be investigated in a growing number of prospective clinical trials to determine optimal treatment protocols. In-office injections are gaining popularity and show promise in the treatment of SGS.

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“…There are many causes of laryngeal stenosis, some are difficult to determine, and the underlying etiology has been misdiagnosed in some cases, leading to inappropriate patient management (3,4). Lymphoma causing laryngeal stricture as initial manifestation has rarely been recognized in clinical practice.…”

mentioning

confidence: 99%

Laryngeal Diffuse Large B-Cell Lymphoma Presenting as Laryngeal Stenosis

Tang¹,

Cua²,

Lai³

2019

In Vivo

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Background: Laryngeal stenosis is challenging for treatment due to uncertain etiology. Primary laryngeal lymphoma as the initial clinical manifestation of laryngeal stenosis has been rarely reported. Primary diffuse large B-cell lymphoma as an underlying etiology has not been reported. Case Report: A 79-year-old male presented with dyspnea, stridor and dysphonia of 6 months' duration. Computed tomography scans and flexible laryngoscopic examination revealed vocal cord mobility with bilaterally limited abduction and a subglottic stenosis up to 50%. The laryngeal mucosa was smooth. Laryngeal biopsy showed atypical lymphoid infiltrates, predominantly large sized B-cells, in the submucosa with crush/cauterized artifacts. The tumor cells were positive for B-lymphocyte antigen CD20, paired-box 5 (PAX5), B-cell lymphoma 2 (BCL2), BCL6 and multiple myeloma oncogene 1 (MUM1). They were negative for CD10, CD30, cyclin D1 (CCND1), SRY-box 11 (SOX11), activin-receptor like kinase 1 (ALK1), CD138 and c-MYC, and negative for kappa/lambda light chain and Epstein-Barr virus-encoded small RNA by in situ hybridization. The pathologic diagnosis was diffuse large B-cell lymphoma. Fluorescent in situ hybridization (FISH) for MYC was negative. Next-generation sequencing using a 175gene panel was performed and no pathologic mutations were identified. No lymphadenopathy elsewhere was identified. The patient was treated with chemotherapy and was doing well at the 5-month follow-up. Conclusion: To the best of our knowledge, this is the first documented case of primary laryngeal diffuse large B-cell lymphoma presenting as increasing laryngeal stenosis. The rarity, diagnosis and treatment of this entity are discussed.

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Ground zero: not asthma at all

Cited by 11 publications

References 38 publications

Asthma and allergic rhinitis in childhood: what's new

Asthma and allergic rhinitis in childhood: what's new

An Updated Review of Subglottic Stenosis: Etiology, Evaluation, and Management

Laryngeal Diffuse Large B-Cell Lymphoma Presenting as Laryngeal Stenosis

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