Rare Case of Cystic Lymphangioma Transforming Into Lymphangiosarcoma: A Case Report

Yu, Huili; Mao, Qinxiang; Zhou, Lingyan; Li, Jiawei; Xu, Xunhua

doi:10.3389/fonc.2022.814023

Cited by 5 publications

(6 citation statements)

References 18 publications

(18 reference statements)

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“…Even more infrequently, there have been resultant squamous cell carcinomas, verruciform xanthomas, and lymphangiosarcomas that have been associated with lymphangiomas. Additionally, acquired lymphangiomas are at risk for complications due to bacterial infections, as they can have poor lymphatic drainage [ 1 , 9 , 10 ].…”

Section: Discussionmentioning

confidence: 99%

Inguinal Intranodal Lymphangioma in an Adult: A Clinical Case Report

Vásquez-Castillo,

Moreira,

Guarecuco Castillo

et al. 2023

Cureus

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Lymphangiomas are benign deformities of the lymphatic system that are most common in pediatric populations and are usually found in the neck, axilla, chest wall, cervicofacial, and pelvic regions, as they are areas with more lymphatic activity. Herein, we report the case of a 43-year-old African-American male who presented with bilateral inguinal lymphangiomas, the first documented incidence of its kind. This patient presented with several months of bilateral swellings in his groin area, accompanied by increased tenderness and discomfort. A physical exam revealed that the left groin swelling was larger than the right groin swelling and that the left lymph node was about < 2 cm in size. Bilaterally, there was no tenderness of the lymph nodes in the area and no skin changes, ulceration, induration, discharge, or bleeding from the site. The diagnostic assessment included ultrasound, a left inguinal lymphadenectomy, and a frozen section biopsy to provide a definitive diagnosis. The pathology report described the lesion as a benign lymphangioma and was negative for lymphoproliferative lesions.

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Section: Discussionmentioning

confidence: 99%

Inguinal Intranodal Lymphangioma in an Adult: A Clinical Case Report

Vásquez-Castillo,

Moreira,

Guarecuco Castillo

et al. 2023

Cureus

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“…However, reports are not non-existent. A case has been reported of a lymphangioma transforming into a malignant lymphangiosarcoma[ 12 ]. Further studies are required but are probably limited due to the rarity of lymphangiomas, especially in adults.…”

Section: Discussionmentioning

confidence: 99%

Surgical excision of a large retroperitoneal lymphangioma: A case report

Park¹,

Lee²,

Maeng³

et al. 2022

World J Clin Cases

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BACKGROUND Lymphangiomas are rare benign tumors most commonly found in children under 2 years of age; adult cases are extremely rare. Retroperitoneal lymphangiomas represent less than 1% of all lymphangiomas. Because of their benign nature and possibility of spontaneous resolution, lymphangiomas are sometimes left untreated for long periods of time. However, if they grow large enough to compress surrounding structures, retroperitoneal lymphangiomas may cause symptoms such as abdominal pain, nausea or vomiting. We report a case of a rapidly growing retroperitoneal lymphangioma in an adult, treated with complete surgical excision. CASE SUMMARY A 60-year-old female who was diagnosed with an intra-abdominal cystic mass (11 cm × 9.5 cm) seven years ago presented to our hospital with symptoms of early satiety, nausea, and intermittent abdominal pain. Computed tomography (CT) scan confirmed interval enlargement to a 24 cm × 22 cm-sized huge left retroperitoneal mass, causing left hydronephrosis by external compression. Laparotomy was done via long midline incision. Due to severe adhesion between the aorta and the medial border of the mass, the cyst was intentionally opened for fluid aspiration and size reduction. After suture closure of the opening, we proceeded carefully with dissection. Aspiration showed light yellowish serous fluid. The mass was excised completely, and the pathology was consistent with cystic lymphangioma. The post-operative period was uneventful, and the patient was discharged without complications. Follow-up CT scan one month after surgery confirmed complete removal of the mass and decreased left hydronephrosis. CONCLUSION Excision of the huge retroperitoneal cystic mass resulted in relief of the patient’s symptoms, originally caused by external compression, and also ruled out the possibility of malignancy.

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“…(Figure 6A) Immunohistochemical stains for vascular markers: CD34 (Figure 5B), ERG, CD31 (Figure 6C), and D2-40 (Figure 5C, 6B), allow their diagnosis and distinction from epithelial lesions. Rare cases of malignant transformation have been reported, [34][35][36][37] therefore, atypical vascular lesions require long-term clinical follow-up. Most cases are managed with total or partial splenectomy.…”

Section: Hemangioma and Lymphangiomamentioning

confidence: 99%

“…Alternative treatments such as aspiration, drainage and radiation are usually unsuccessful. 36,38,39 Incomplete resection warrants clinical follow-up, as recurrence is not rare. 34,35 Hamartoma Hamartomas, also called splenomas or nodular hyperplasia of the spleen, can occur at any age without gender predilection.…”

Section: Hemangioma and Lymphangiomamentioning

confidence: 99%

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Differential Diagnosis of Cystic Lesions of the Spleen: A Review of Clinical, Imaging and Pathological Findings

et al. 2022

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Cystic lesions of the spleen are being noticed with increased frequency as “incidentalomas” during imaging work-up for unrelated causes. As a group, these lesions encompass pure cystic and mixed cystic and solid, benign and malignant processes that in general require a tissue sample for definitive diagnosis. In this review, we will describe the differential diagnosis of cystic lesions of the spleen, highlighting key imaging, clinical and pathologic findings.

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Rare Case of Cystic Lymphangioma Transforming Into Lymphangiosarcoma: A Case Report

Cited by 5 publications

References 18 publications

Inguinal Intranodal Lymphangioma in an Adult: A Clinical Case Report

Inguinal Intranodal Lymphangioma in an Adult: A Clinical Case Report

Surgical excision of a large retroperitoneal lymphangioma: A case report

Differential Diagnosis of Cystic Lesions of the Spleen: A Review of Clinical, Imaging and Pathological Findings

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