2022
DOI: 10.3389/fonc.2022.814023
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Rare Case of Cystic Lymphangioma Transforming Into Lymphangiosarcoma: A Case Report

Abstract: Cystic lymphangioma (CL) is a rare benign tumor that mainly occurs in the neck and axilla and usually occurs in children, whereas lymphangiosarcoma (LAS) is a rare invasive tumor, usually secondary to chronic lymphedema caused by various causes, with a rare malignant transformation from CL. We presented the case of a 63-year-old woman who underwent four surgical excisions for multiple recurrence of CL in the right groin. The changes of imaging and pathological examination revealed the unusual process of its gr… Show more

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Cited by 5 publications
(6 citation statements)
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References 18 publications
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“…Even more infrequently, there have been resultant squamous cell carcinomas, verruciform xanthomas, and lymphangiosarcomas that have been associated with lymphangiomas. Additionally, acquired lymphangiomas are at risk for complications due to bacterial infections, as they can have poor lymphatic drainage [ 1 , 9 , 10 ].…”
Section: Discussionmentioning
confidence: 99%
“…Even more infrequently, there have been resultant squamous cell carcinomas, verruciform xanthomas, and lymphangiosarcomas that have been associated with lymphangiomas. Additionally, acquired lymphangiomas are at risk for complications due to bacterial infections, as they can have poor lymphatic drainage [ 1 , 9 , 10 ].…”
Section: Discussionmentioning
confidence: 99%
“…However, reports are not non-existent. A case has been reported of a lymphangioma transforming into a malignant lymphangiosarcoma[ 12 ]. Further studies are required but are probably limited due to the rarity of lymphangiomas, especially in adults.…”
Section: Discussionmentioning
confidence: 99%
“…(Figure 6A) Immunohistochemical stains for vascular markers: CD34 (Figure 5B), ERG, CD31 (Figure 6C), and D2-40 (Figure 5C, 6B), allow their diagnosis and distinction from epithelial lesions. Rare cases of malignant transformation have been reported, [34][35][36][37] therefore, atypical vascular lesions require long-term clinical follow-up. Most cases are managed with total or partial splenectomy.…”
Section: Hemangioma and Lymphangiomamentioning
confidence: 99%
“…Alternative treatments such as aspiration, drainage and radiation are usually unsuccessful. 36,38,39 Incomplete resection warrants clinical follow-up, as recurrence is not rare. 34,35 Hamartoma Hamartomas, also called splenomas or nodular hyperplasia of the spleen, can occur at any age without gender predilection.…”
Section: Hemangioma and Lymphangiomamentioning
confidence: 99%
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