Differential Diagnosis of Cystic Lesions of the Spleen: A Review of Clinical, Imaging and Pathological Findings

Yocum, Bianca Puello; Hwang, Michael; Mesa, Hector; Collins, Katrina

doi:10.1177/10668969221107080

Cited by 4 publications

(3 citation statements)

References 71 publications

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“…Focal lesions appear as low-density areas in the imaging with little or no enhancement following injection of intravenous contrast medium. Ahmann classified lymphomatous involvement of the spleen into the following four categories: (1) homogeneous enlargement without masses, (2) miliary masses, (3) 2-10 cm masses, and (4) a large solitary mass [4][5][6][7]. Significant necrosis may also occur with a large tumor but extensive necrosis like the necrosis observed in our case is extremely rare.…”

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confidence: 51%

Unusual Rapid Growth of Primary Splenic Diffuse Large B-Cell Lymphoma with Extensive Necrosis

Chen¹,

Chen

2022

Diagnostics

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The primary splenic lymphoma is extremely uncommon with an incidence rate of <1% of all the lymphomas under the strict criteria for diagnosis expounded by Das Gupta et al. Clinical presentations of nonspecific symptoms are weight loss, weakness, fever, and left upper quadrant pain or discomfort due to enlarged spleen. Abdominal ultrasound and CT are the most widely used imaging modality for the assessment of lymphoma. The imaged features of splenic lymphoma are nonspecific; typical lymphoma presents as a diffusely enlarged spleen. The abdominal CT scan in our case showed a large cystic splenic mass measuring 14 cm without enhancement after contrast medium. Lymphoma is often described as an aggressive tumor because its rapid doubling time can quickly increase the size of a tumor. In our case, the tumor grew to more than 100 times its original size in 4 months. So, we present this unusual rapid growth of primary splenic lymphoma.

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confidence: 51%

Unusual Rapid Growth of Primary Splenic Diffuse Large B-Cell Lymphoma with Extensive Necrosis

Chen¹,

Chen

2022

Diagnostics

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“…Cystic lesions with a dense content may mimic a solid lesion, particularly on US and on unenhanced CT (Figure 3). At the same time, apparently solid lesions may lack any contrast enhancement on US, CT, or MRI, turning out to be cystic [23]. The spleen is the third most common site for hydatid cysts, and, therefore, in some geographical regions, Echinococcus granulosus is one of the most common causes of spleen cystic lesion [9].…”

Section: Cystic Lesionsmentioning

confidence: 99%

Section: Cystic Lesionsmentioning

confidence: 99%

Incidental Focal Spleen Lesions: Integrated Imaging and Pattern Recognition Approach to the Differential Diagnosis

Corvino,

Granata,

Tafuri

et al. 2023

Diagnostics

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Spleen lesions and pseudolesions, detected incidentally in imaging, are not uncommon and may require further work-up. The imaging appearance of focal splenic lesions (FSLs) may not be pathognomonic, because of considerably overlapping features. Consequently, all imaging techniques lack specificity to fully characterize FSLs. Clinical correlation is mandatory, so as, first of all, to categorize the patient as having or not having a history of solid or hematologic malignancy. Nowadays, many patients have old imaging studies available for comparison and, consequently, it is important to understand if the lesion was previously present or not, and if the size is the same or has changed. In the absence of comparison studies, and with a lack of imaging features of benignity, further investigation may be necessary, using PET, biopsy, or short-term follow-up. Some algorithms have been proposed to manage incidental FSLs; however, none of these strategies has been validated by prospective studies to date. In this review we illustrate the topic of incidental FSLs and we analyze a number of published algorithms.

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Splenic lymphangiomas as a common indication for splenectomy: a case series with literature review

et al. 2022

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Background Splenic lymphangiomas (SL) are very rare benign cystic lesions found in pediatric population. Their occurrence in adults is exceptional. Splenectomy is the common management of splenic lesions for diagnostic and/or therapeutic purpose. Our aim is to report additional cases of SL diagnosed on splenectomy specimens at our Pathology laboratory with literature review. Methods This is a retrospective study including all cases of splenectomy recorded at our Pathology laboratory (June 2020–August 2022). We performed a comparison of clinicopathological features between patients with SL and those with other benign splenic diseases. Results Sixteen cases of splenectomy were included. The mean age was 30.25 years (range of 6–70 years). The final histopathological diagnoses were congestive spleens in all cases of sickle cell disease (SCD) (5/16 patients, 31.25%), splenic cystic lymphangiomas (4/16 patients, 25%), capsular splenic infiltration by gastric and colic cancers (3/16 cases, 18.75%), splenic abscess (2/16 cases, 12.5%) and splenic rupture with subcapsular hematoma (1/16 patients, 6.25%). 12/16 patients (75%) had benign splenic conditions (4/12 with SL, 5/12 with SCD, 2/12 with abscess and 1/12 with splenic trauma). Patients with SL were older than those with other benign splenic conditions (mean age of 28.27 years versus 20.87 years). Also patients with SL presented with massive splenomegaly (mean splenic weight of 1675 g versus 418.75 g, mean splenic size of 19.62 cm versus 14.63 cm). Open surgery was performed in 15/16 patients (93.75%). Conclusion Unlike previous studies, our series shows that SL are a common indication for splenectomy and occur in older patients with massive cystic splenomegaly. Open splenectomy is still an usual surgical practice in our country.

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Differential Diagnosis of Cystic Lesions of the Spleen: A Review of Clinical, Imaging and Pathological Findings

Cited by 4 publications

References 71 publications

Unusual Rapid Growth of Primary Splenic Diffuse Large B-Cell Lymphoma with Extensive Necrosis

Unusual Rapid Growth of Primary Splenic Diffuse Large B-Cell Lymphoma with Extensive Necrosis

Incidental Focal Spleen Lesions: Integrated Imaging and Pattern Recognition Approach to the Differential Diagnosis

Splenic lymphangiomas as a common indication for splenectomy: a case series with literature review

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