Rare case of anaplastic plasmacytoma in the sinonasal tract

Abstract

Background Extramedullary plasmacytomas are tumors that develop from plasma cells and rarely express anaplastic features. To our knowledge, there have only been three reported cases of anaplastic plasmacytomas of the sinonasal tract in the English literature. We detail the fourth case. Methods A 70‐year‐old male was seen with a 4‐month history of nasal congestion, bloody mucous, and left sided nasal obstruction. On positron emission tomography/computed tomography, the lesion was FDG‐avid with an SUVmax of 25.1. A biopsy of the lesion and subsequent immunohistochemical staining confirmed the diagnosis of an anaplastic plasmacytoma. Results The patient is undergoing a 5‐week course of curative‐intent radiation therapy. Conclusion Extramedullary plasmacytomas with anaplastic features are very rare. We highlight the value of thorough histopathological review and detailed immunostains to arrive at a diagnosis of anaplastic extramedullary plasmacytoma.

International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors

“…These findings help distinguish EMPs from inflammatory processes that may be rich in plasma cells. An anaplastic subtype of EMPs has been described with characteristic increased number of mitotic figures 1879 . It may be difficult to distinguish EMPs from a low‐grade BCL with significant plasma cell differentiation.…”

A rare case of extramedullary rectal anaplastic plasmacytoma at the site of previously surgically resected rectal adenocarcinoma

“…Results We report the case of a 62-year-old patient previously diagnosed with non-metastatic adenocarcinoma of the rectum operated with a low anterior resection. During follow-up, 5 years after initial diagnosis and surgical resection, the patient presented with episodes of rectal bleeding and endoscopic examination revealed a hemorrhagic ulcerated invasive lesion where multiple biopsies were obtained 1 2 3 .…”