Rare Association between Prostate Adenocarcinoma and Schistosomiasis: A Case Report

Abstract

ResumoA shistossomíase humana, a segunda doença parasitária mais devastadora, é comum nos países em desenvolvimento, mas é rara na Europa. O envolvimento do aparelho urogenital deve-se sobretudo a infecção por Schistosoma haematobium. A schistossomíase tem sido associada com neoplasias malignas, desde há algum tempo. Alguns autores têm colocado a hipótese de existir uma relação causal entre schistossomíase e cancro do intestino, rim, bexiga e próstata. Até à data, estão descritos apenas 17 casos de adenocarcinoma e schistossomíase da próstata concomitantes. Como um exemplo raro de uma potencial complicação de schistossomíase não tratada, relatamos um caso de schistossomíase urinária incidentalmente diagnosticada após prostatectomia radical por adenocarcinoma da próstata, num homem Africano de 62 anos, a residir numa área não endémica.

Association of schistosomiasis and risk of prostate cancer development in residents of Murehwa rural community, Zimbabwe

“…On the contrary to observations of prostatic schistosomiasis infection progressing over time as represented by a patient with prostate adenocarcinoma and high prostate-specific antigen levels (11.59 ng/mL) reported by Metrogos et. al in 2017 [ 36 ], we observed insignificant lower prostate-specific antigen levels of among participants with history of schistosomiasis infection compared to those without history of schistosomiasis infection. Therefore, history of schistosomiasis infection may not necessarily an indicator of prostate cancer development.…”

“…The genital lesions may lead to events that could indirectly lead to carcinogenesis. S. haematobium and S. mansoni associated prostate adenocarcinoma cases has been reported in different schistosomiasis endemic countries such as Angola, Egypt, South Africa and Brazil and also schistosomiasis non endemic areas such as USA and Iraq [ 33 – 36 ]. Thus available literature, though very limited, suggests a possible association of schistosomiasis infection with the development of prostate cancer particularly in schistosomiasis endemic areas.…”

Inflammation‐associated pathologies in a case of prostate schistosomiasis: Implications for a causal role in prostate carcinogenesis

“…We reviewed the published literature on schistosomiasis and prostate cancer (Table 1), which comprised 11 case reports. [19][20][21][22][23][24][25][26][27][28][29] The reports cover S. haematobium, S. mansoni, and unidentified species of Schistosoma, and a range of geographic locations (Table 1).…”

Interleukin-13 rs1800925/-1112C/T promoter single nucleotide polymorphism variant linked to anti-schistosomiasis in adult males in Murehwa District, Zimbabwe

“…Limited reports on Schistosoma ova and prostate cancer co-existence have been reported suggesting possible prostate cancer evolution due to schistosomiasis infection [39][40][41][42]. Prostate cancer is one of the most common cancer in Zimbabwe [43].…”