Rapidly in situ forming chitosan/ε-polylysine hydrogels for adhesive sealants and hemostatic materials

Nie, Wei; Yuan, Xiaoyan; Zhao, Jin; Zhou, Yalin; Bao, Hongduo

doi:10.1016/j.carbpol.2013.04.008

Cited by 117 publications

(62 citation statements)

References 36 publications

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“…Since it can happen by simply blending the starting materials under mild conditions without any by-products, Michael addition is a better choice for in situ formation of biocompatible hydrogels [90,91]. Nie et al [40] developed a novel polysaccharides/polypeptide hydrogel for application as adhesive sealant and hemostatic material by fast in situ crosslinking thiol functionalized chitosan (CSS) with maleimide group modified ε-polylysine (EPLM) via Michael addition under mild conditions (Figure 6). Due to similarity with the natural extracellular matrix, the CSS/EPLM hydrogel showed no cytotoxicity.…”

Section: Cs-based Composite Hemostatic Materialsmentioning

confidence: 99%

Chitosan-Based Composite Materials for Prospective Hemostatic Applications

et al. 2018

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Effective hemostasis is vital to reduce the pain and mortality of patients, and the research and development of hemostatic materials are prerequisite for effective hemostasis. Chitosan (CS), with good biodegradability, biocompatibility and non-toxicity, has been widely applied in bio-medicine, the chemical industry, the food industry and cosmetics. The excellent hemostatic properties of CS have been extensively studied. As a result, chitosan-based composite hemostatic materials have been emerging. In this review, the hemostatic mechanism of chitosan is briefly discussed, and then the progress of research on chitosan-based composite hemostatic materials with multiple forms such as films, sponges, hydrogels, particles and fibers are introduced. Finally, future perspectives of chitosan-based composite hemostatic materials are given. The objective of this review is to provide a reference for further research and development of effective hemostatic materials.

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Section: Cs-based Composite Hemostatic Materialsmentioning

confidence: 99%

Chitosan-Based Composite Materials for Prospective Hemostatic Applications

et al. 2018

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“…reported the formation of a composite hydrogel based on thiol containing chitosan (Figure 3a, v) and maleimide containing ε-polylysine [56]. The Michael addition reaction between thiol and maleimide groups led to the in situ formation of a crosslinked hydrogel upon simply mixing of the two components.…”

Section: Sealants Based On Natural Biopolymersmentioning

confidence: 99%

Elastic sealants for surgical applications

Annabi

Yue

Tamayol

et al. 2015

European Journal of Pharmaceutics and Biopharmaceutics

190

167

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Sealants have emerged as promising candidates for replacing sutures and staples to prevent air and liquid leakages during and after the surgeries. Their physical properties and adhesion strength to seal the wound area without limiting the tissue movement and function are key factors in their successful implementation in clinical practice. In this contribution, the advances in the development of elastic sealants formed from synthetic and natural materials are critically reviewed and their shortcomings are pointed out. In addition, we highlight the applications in which elasticity of the sealant is critical and outline the limitations of the currently available sealants. This review will provide insights for the development of novel bioadhesives with advanced functionality for surgical applications.

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“…For this purpose, a thiol-maleimide reaction was chosen because it is rapid (i.e.,~1000 times faster than an aminedirected reaction), controllable, and specific at biological pH values (~7.4) [29]. Furthermore, the frequency of free cysteine (thiol) occurrence is usually very low in proteins [24][25][26][27][28][29][30][31][32][33], and thus, loaded proteins are unlikely to react with the maleimide groups of PEG. To explore the practical advantages of our hydrogel made using thioether linkages (HSA-SH/PEG-MAL hydrogel, Fig.…”

Section: Preparation and Characterization Of Hsa-sh/peg-mal Hydrogelmentioning

confidence: 99%

“…HSA-SH/PEG-MAL hydrogel was prepared as previously described method with slight modification [25,26]. Human serum albumin (HSA, 40 mg) was dissolved in 0.2 mL of PBS (pH 8.0, 10 mM) and mixed with predetermined equivalents of 2-iminothiolane (2-IT = Traut's reagent; 9-24 M equivalents (eq.)…”

Section: Fabrication Of Hsa-sh/peg-mal Hydrogelmentioning

confidence: 99%