In situ facile-forming PEG cross-linked albumin hydrogels loaded with an apoptotic TRAIL protein

Kim, In-Soo; Choi, Ji Su; Lee, Seung–Hyun; Byeon, Hyeong Jun; Lee, Eun Seong; Shin, Beom Soo; Choi, Han‐Gon; Lee, Kang Choon; Youn, Yu Seok

doi:10.1016/j.jconrel.2015.07.012

Cited by 50 publications

(29 citation statements)

References 62 publications

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“…Chemical crosslinking is the most reported method to derive albumin hydrogels (Abbate, Kong, & Bansal, ; Bai et al, ; Feldman & McCauley, ; Gallego, Junquera, Meana, Álvarez‐Viejo, & Fresno, ; Gallego, Junquera, Meana, García, & García, ; He, Jean‐Francois, & Fortier, ; Hirose, Tachibana, & Tanabe, ; Kim et al, ; Li et al, ; Lisman, Butruk, Wasiak, & Ciach, ; Ma et al, ; Manokruang & Lee, ; Noteborn, Gao, Jesse, Kros, & Kieltyka, ; Oss‐Ronen & Seliktar, ; Overby & Feldman, ; Raja, Thiruselvi, Mandal, & Gnanamani, ; Scholz et al, ; Upadhyay & Rao, ; Zhao et al, ; Zhou et al, ). Synthetic polymers such as polyethylene glycol (PEG) are activated to form PEG‐albumin complexes (e.g., with 4‐nitrophenyl‐chloroformate), or alternatively functional groups may be added to the ends of the PEG molecule to target specific chemical compositions or binding sites of other target proteins for conjugation.…”

Section: Synthesis Of Albumin Hydrogelsmentioning

confidence: 99%

“…The role of albumin molecules in drug delivery is well established, however research in albumin hydrogels for controlled drug release and delivery is still growing. Kim et al () utilized a PEG‐HSA hydrogel loaded with an apoptotic TRAIL protein to successfully induce cancer cell death and reduce tumor size in a murine model injected with a pancreatic cancer cell line (Mia Paca‐2). Successful controlled drug release was also demonstrated using a composite hydrogel (Dextran‐HSA‐PEG) loaded with anticancer drug doxorubicin to eliminate breast cancer cells (MCF‐7) in vitro (Noteborn et al, ).…”

Section: Biological Effects and Usesmentioning

confidence: 99%

“…PEG‐albumin hydrogels generally have a more predictable degradation period of approximately 2 to 4 weeks with no local side effects. An HSA‐SH/PEG‐MAL hydrogel was reduced to 28% of its initial weight after 21 days in an immunodeficient mouse model (Figure ; Kim et al, ). Interestingly, only one study to date has created albumin hydrogels derived from species‐specific serum for in vivo experimentation.…”

Section: Biodegradabilitymentioning

confidence: 99%

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Albumin‐based hydrogels for regenerative engineering and cell transplantation

Ong

Zhao

Justin

et al. 2019

Biotech & Bioengineering

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Albumin, the most abundant plasma protein in mammals, is a versatile and easily obtainable biomaterial. It is pH and temperature responsive, dissolvable in high concentrations and gels readily in defined conditions. This versatility, together with its inexpensiveness and biocompatibility, makes albumin an attractive biomaterial for biomedical research and therapeutics. So far, clinical research in albumin has centered mainly on its use as a carrier molecule or nanoparticle to improve drug pharmacokinetics and delivery to target sites. In contrast, research in albumin‐based hydrogels is less established albeit growing in interest over recent years. In this minireview, we report current literature and critically discuss the synthesis, mechanical properties, biological effects and uses, biodegradability and cost of albumin hydrogels as a xeno‐free, customizable, and transplantable construct for tissue engineering and regenerative medicine.

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Section: Synthesis Of Albumin Hydrogelsmentioning

confidence: 99%

Section: Biological Effects and Usesmentioning

confidence: 99%

Section: Biodegradabilitymentioning

confidence: 99%

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Albumin‐based hydrogels for regenerative engineering and cell transplantation

Ong

Zhao

Justin

et al. 2019

Biotech & Bioengineering

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“…The thiol-maleimide reaction was chosen because it is rapid and controllable. 27 Throughout this in situ crosslinking reaction, the nanoparticles and Los were simultaneously encapsulated in the gel matrix. As shown in Figure 3A and B, combining solutions of 4-arm PEG-Mal, FPNPs, Los, and HS-MMP-SH resulted in a non-liquid and transparent pink hydrogel.…”

Section: Preparation and Characterization Of Fpnp/los-loaded Hydrogelmentioning

confidence: 99%

Peritumoral implantation of hydrogel-containing nanoparticles and losartan for enhanced nanoparticle penetration and antitumor effect

Shen¹,

Gao²,

Qi³

et al. 2018

IJN

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Background and purposeNanoparticle-loaded hydrogels – localized drug delivery devices containing a combination of therapeutic nanoparticles and implantable hydrogel – have been recipients of increased focus and interest for cancer treatment. However, it is difficult for the released nanoparticles to penetrate deeply into tumors because of the dense collagen network in the tumor extracellular matrix, which greatly limits their antitumor effect. We hypothesized that the implantation of a hydrogel loaded with both nanoparticles and losartan (Los) might enhance penetration because Los has been proven to effectively reduce collagen levels in various tumors. Herein, we developed a nanoparticle/Los-loaded hydrogel system and evaluated the intratumoral distribution and anticancer effect after peritumoral implantation of nanoparticles.MethodsFluorescent polystyrene nanoparticles (FPNPs, size ~100 nm) and Los were simultaneously encapsulated in a polyethylene glycol (PEG) hydrogel to form the FPNP/Los-loaded hydrogel. After peritumoral implantation in 4T1 tumor-bearing mice for 2 weeks, intratumoral distributions of FPNPs and collagen level were determined. Based on the results, liposomal doxorubicin (Doxil, ~100 nm) was subsequently substituted for FPNPs in the hydrogel. The cellular uptake and cytotoxicity of the Doxil/Los-loaded hydrogel were studied, and the in vivo antitumor efficacy after peritumoral implantation was evaluated.ResultsCompared with a standard FPNP-loaded hydrogel, the FPNP/Los-loaded hydrogel resulted in enhanced penetration and reduced collagen levels after implantation. Thereafter, the potential of a Doxil/Los-loaded hydrogel for cancer treatment was studied. Doxorubicin was released from the hydrogel and induced effective cytotoxicity against 4T1 cells. The Doxil/Los-loaded hydrogel showed synergistic antitumor effects in 4T1 tumor-bearing mice and was more effective at tumor inhibition than the Doxil-loaded hydrogel.ConclusionThis study provides a proof of principle that the implantation of nanoparticles/Los-loaded hydrogel can increase the intratumoral distribution and antitumor efficacy of nanoparticles, owing to collagen depletion by Los. Future studies may build on this strategy for enhanced tumor penetration of nanoparticles.

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“…It can serve as a sustained‐release nanoparticle to enhance the stability and biological activity of TRAIL ( Figure ). TRAIL‐HSA‐NPs (TRAIL loaded into HSA nanoparticles) prolonged the half‐life of TRAIL, increased its tumor distribution, and ultimately improved antitumor efficacy after intravenous administration …”

Section: Nanotrail Treatment In Preclinical Researchmentioning

confidence: 99%

NanoTRAIL‐Oncology: A Strategic Approach in Cancer Research and Therapy

Shi

Pang

Wang

et al. 2018

Adv Healthcare Materials

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TRAIL is a member of the tumor necrosis factor superfamily that can largely trigger apoptosis in a wide variety of cancer cells, but not in normal cells. However, insufficient exposure to cancer tissues or cells and drug resistance has severely impeded the clinical application of TRAIL. Recently, nanobiotechnology has brought about a revolution in advanced drug delivery for enhanced anticancer therapy using TRAIL. With the help of materials science, immunology, genetic engineering, and protein engineering, substantial progress is made by expressing fusion proteins with TRAIL, engineering TRAIL on biological membranes, and loading TRAIL into functional nanocarriers or conjugating it onto their surfaces. Thus, the nanoparticle-based TRAIL (nanoTRAIL) opens up intriguing opportunities for efficient and safe bioapplications. In this review, the mechanisms of action and biological function of TRAIL, as well as the current status of TRAIL treatment, are comprehensively discussed. The application of functional nanotechnology combined with TRAIL in cancer therapy is also discussed.

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In situ facile-forming PEG cross-linked albumin hydrogels loaded with an apoptotic TRAIL protein

Cited by 50 publications

References 62 publications

Albumin‐based hydrogels for regenerative engineering and cell transplantation

Albumin‐based hydrogels for regenerative engineering and cell transplantation

Peritumoral implantation of hydrogel-containing nanoparticles and losartan for enhanced nanoparticle penetration and antitumor effect

NanoTRAIL‐Oncology: A Strategic Approach in Cancer Research and Therapy

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