Rapidly Growing Squamous Cell Carcinoma of the Tongue

Myers, Dominick; Allen, Emily H.; Essa, Amr; Gbadamosi-Akindele, Maryam

doi:10.7759/cureus.7164

Cited by 4 publications

(5 citation statements)

References 7 publications

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“…In many parts of the world, new cases of oral cancer and deaths are increasing. Known risk factors include smoking, drinking, human papillomavirus (HPV) and betel quid chewing 1 . It is additionally believed that exposure to heavy metals, as well as emissions from petroleum and chemical plants, is also related to the development of oral cancer.…”

Section: Introductionmentioning

confidence: 99%

Surfactin from Bacillus subtilis induces apoptosis in human oral squamous cell carcinoma through ROS-regulated mitochondrial pathway

Vo¹,

Liu²,

Wu³

et al. 2020

J. Cancer

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Recently, ambient air particulate matter (PM) has been shown to increase the risk of oral cancer. The most common malignant tumor in the oral cavity is oral squamous cell carcinoma (OSCC). Recent studies have revealed that surfactin, a cyclic lipopeptide generated by Bacillus subtilis , has anti-inflammatory and anti-cancer properties. However, the exact anti-cancer effects of surfactin on human OSCC and underlying molecular mechanisms remain largely unknown. In the present study, we found that treatment of SCC4 and SCC25 cells (human OSCC cell lines) with surfactin reduced the viability of SCC4 and SCC25 cells by induction of apoptosis. Surfactin-induced apoptosis was associated with caspase activation and poly(ADP-ribose) polymerase (PARP) cleavage and was regulated by the mitochondrial pathway, exemplified by mitochondrial depolarization, mitochondrial-derived reactive oxidative species (ROS) production, cytochrome c release, up-regulation of Bad and Bax, and down-regulation of Bcl-2. Surfactin induced NADPH oxidase-dependent ROS generation, which appeared essential for the activation of the mitochondrial pathway. Surfactin-induced mitochondrial-derived ROS generation was associated with JNK1/2 activation. After treatment with surfactin, ROS caused JNK1/2-dependent cell death of SCC4 and SCC25 cells. Taken together, our findings suggest that surfactin induces mitochondria associated apoptosis of human OSCC cell lines, and surfactin may be a potential chemotherapeutic agent for future OSCC treatment.

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Section: Introductionmentioning

confidence: 99%

Surfactin from Bacillus subtilis induces apoptosis in human oral squamous cell carcinoma through ROS-regulated mitochondrial pathway

Vo¹,

Liu²,

Wu³

et al. 2020

J. Cancer

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“…Neurodegenerative diseases have become a global problem affecting mostly older adults. Parkinson's disease (PD), a type of ND, is major motor disorder, and the second most common neurodegenerative age-related disorder [19]. This disease is of great clinical and Institute of Experimental Morphology, Pathology and Anthropology with Museum Bulgarian Anatomical Society Acta Morphologica et Anthropologica, 29 (3)(4) Sofia • 2022 economic importance due to its effect on mobility in the elderly.…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective Role of Caffeic Acid in Lipopolysaccharide-induced Neurodegeneration in Mice

Iteire¹,

Udawnojo²,

Odokuma³

2022

AMA

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This study aimed to investigate the anti-inflammatory role of Caffeic acid (CFA) on Lipopolysaccharide (LPS)-induced neurotoxicity by quantifying astrocyte and microglial activation. Mice were randomly divided into Groups A-D (n=8). Group A, the Control group, received water; B (Neurotoxicity model) received LPS for seven days and sacrificed; C (Neurotoxicity and anti-inflammatory model) received LPS and caffeic acid concurrently, D (Positive control) received caffeic acid. All administrations were through oral gavage once daily at 08:00 hours, and the experiment lasted 14 days. An open field test (OFT) was used to assess the effect of LPS and other treatments on the exploratory behavior of the animals. LPS-induced neurotoxicity reduced mice's motor activities, significant degeneration of cerebral neurons, and increased cerebral GFAP (glial fibrillary acidic protein) and Iba1 (ionized calciumbinding adapter molecule 1) immuno-reactivity. The study also establishes the ameliorating effect of CFA on LPS-induced neurotoxicity by restoring cerebral histoarchitecture, improving motor activities, and reducing cerebral GFAP and Iba1 expression.

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“…More than 90% of tongue cancer is squamous cell carcinoma (SCC) and the commonest site is the lateral border of the tongue. (2) . Tongue (SCC) mostly involves the older age group exposed to tobacco and alcohol consumption for a long period.…”

Section: Introductionmentioning

confidence: 99%

Reconstruction of glossectomy defects post oncologic resection

Elbaz

Awny

Shoma

2021

Mansoura Medical Journal

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The tongue is a muscular organ completely covered by mucous membrane and made up of two portions divided by the V-shaped sulcus terminalis: an anterior 2/3 (oral tongue) and a posterior 1/3 (tongue base). The tongue is essential to normal speech as well as swallowing process, and healthy tongue function is vital within the general quality of life. Tongue cancers are aggressive tumors with poor prognosis, so the early detection markedly raises the possibility of cure with minimal impairment and deformity.Management needs a surgical, medical and radiation oncologist in association with speech therapist, physical rehabilitation, and psychologists. In addition to regular followup and good family support are leading to better outcomes.The reconstruction of the tongue post oncologic resection results in better speech and swallowing. In addition, there is a variety of flap options, and no one is superior to another, but it depends on the tongue defect size, patient factors, and team expertise. Therefore, the article focuses on tongue reconstruction by using various flap modalities.

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Rapidly Growing Squamous Cell Carcinoma of the Tongue

Cited by 4 publications

References 7 publications

Surfactin from Bacillus subtilis induces apoptosis in human oral squamous cell carcinoma through ROS-regulated mitochondrial pathway

Surfactin from Bacillus subtilis induces apoptosis in human oral squamous cell carcinoma through ROS-regulated mitochondrial pathway

Neuroprotective Role of Caffeic Acid in Lipopolysaccharide-induced Neurodegeneration in Mice

Reconstruction of glossectomy defects post oncologic resection

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