Rapidly advancing necrotizing fasciitis caused by Photobacterium (Vibrio) damsela: A hyperaggressive variant

Goodell, Kristen; Jordan, Michael R.; Graham, Roger A.; Cassidy, Charles; Nasraway, Stanley A.

doi:10.1097/01.ccm.0000104920.01254.82

Cited by 65 publications

(49 citation statements)

References 18 publications

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“…In addition, P. damselae subsp. damselae may be a primary pathogen for mammals, including humans (Morris et al, 1982;Clarridge & Zighelboim-Daum, 1985;Fujioka et al, 1988;Perez-Tirse et al, 1993;Yuen et al, 1993;Shin et al, 1996;Fraser et al, 1997;Tang & Wong, 1999;Goodell et al, 2004;Yamame et al, 2004). A comparatively small number of bacterial species belonging to the family Vibrionaceae causes diseases in both aquatic animals and humans.…”

Section: Pathogenicity and Virulence Factorsmentioning

confidence: 99%

Photobacterium damselae subsp. damselae, an Emerging Pathogen Affecting New Cultured Marine Fish Species in Southern Spain

Labella¹,

Berbel²,

Manchado³

et al. 2011

Recent Advances in Fish Farms

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Section: Pathogenicity and Virulence Factorsmentioning

confidence: 99%

Photobacterium damselae subsp. damselae, an Emerging Pathogen Affecting New Cultured Marine Fish Species in Southern Spain

Labella¹,

Berbel²,

Manchado³

et al. 2011

Recent Advances in Fish Farms

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“…damselae causes severe infections in wild marine animals and in aquaculture. Time and again, septicemia or necrotizing soft tissue infections in humans have also been reported (1)(2)(3)(4)(5)(6). In many cases, even radical surgery and antibiotic treatment fail to save the lives of patients.…”

mentioning

confidence: 99%

Phobalysin, a Small β-Pore-Forming Toxin of Photobacterium damselae subsp. damselae

et al. 2015

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c Photobacterium damselae subsp. damselae, an important pathogen of marine animals, may also cause septicemia or hyperaggressive necrotizing fasciitis in humans. We previously showed that hemolysin genes are critical for virulence of this organism in mice and fish. In the present study, we characterized the hlyA gene product, a putative small ␤-pore-forming toxin, and termed it phobalysin P (PhlyP), for "photobacterial lysin encoded on a plasmid." PhlyP formed stable oligomers and small membrane pores, causing efflux of K ؉ , with no significant leakage of lactate dehydrogenase but entry of vital dyes. The latter feature distinguished PhlyP from the related Vibrio cholerae cytolysin. Attack by PhlyP provoked a loss of cellular ATP, attenuated translation, and caused profound morphological changes in epithelial cells. In coculture experiments with epithelial cells, Photobacterium damselae subsp. damselae led to rapid hemolysin-dependent membrane permeabilization. Unexpectedly, hemolysins also promoted the association of P. damselae subsp. damselae with epithelial cells. The collective observations of this study suggest that membrane-damaging toxins commonly enhance bacterial adherence.

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“…De igual forma, Goodell KH y cols, aislaron Vibrio damsela en E.U.A., en un paciente que desarrolló una fascitis necrosante 30 . Los resultados expuestos en el presente trabajo fueron semejantes a los de los autores antes mencionados.…”

Section: Discussionunclassified

Aislamiento e identificación de especies pertenecientes a los géneros Aeromonas, Vibrio y Plesiomonas procedentes de muestras extra-intestinales en Cuba

E²,

et al. 2007

Rev. chil. infectol.

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Introducciónos bacilos gramnegativos, anaerobios facultativos, oxidasa positiva, pertenecen a los géneros Aeromonas, Vibrio y Plesiomonas, ubicados taxonómicamente en las familias Aeromonadaceae, Vibrionaceae y Enterobacteriaceae, respectivamente 1 .Es reconocido el incremento de las infecciones por los microorganismos pertenecientes a los mencionados géneros, como agentes etiológicos de procesos infecciosos en órganos y sistemas vitales para el organismo, comprometiendo en ocasiones la vida del paciente 2-4 .A pesar de los adelantos en el control de las enfermedades transmisibles, cada día son más frecuentes las infecciones intestinales, extra-intestinales y nosocomiales por las especies de los géneros descritos anteriormente, constituyendo una amenaza grave para la salud de la población mundial, por el amplio espec-

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Rapidly advancing necrotizing fasciitis caused by Photobacterium (Vibrio) damsela: A hyperaggressive variant

Cited by 65 publications

References 18 publications

Photobacterium damselae subsp. damselae, an Emerging Pathogen Affecting New Cultured Marine Fish Species in Southern Spain

Photobacterium damselae subsp. damselae, an Emerging Pathogen Affecting New Cultured Marine Fish Species in Southern Spain

Phobalysin, a Small β-Pore-Forming Toxin of Photobacterium damselae subsp. damselae

Aislamiento e identificación de especies pertenecientes a los géneros Aeromonas, Vibrio y Plesiomonas procedentes de muestras extra-intestinales en Cuba

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