“…PhlyP and PhlyC exert an additive effect in hemolysis and virulence, whereas all three hemolysins act synergistically on erythrocytes, a phenomenon that accounts for maximum virulence in mice and fish (Rivas et al, 2013a). Recently, we have demonstrated that hemolysins increase bacterial adherence (Rivas et al, 2015b), which may be of paramount relevance in the early events of natural infection. In addition, tissue damage caused by hemolysins may provide a source of nutrients to further support bacterial infection.…”