1997
DOI: 10.1016/s0016-5085(97)70180-x
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Rapid transepithelial antigen transport in rat jejunum: Impact of sensitization and the hypersensitivity reaction

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Cited by 147 publications
(143 citation statements)
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“…These cells can use FcεRI receptor for capturing IgE-complexed Ag. More interestingly, the sensitization can increase uptake of specific Ag via an endosomal transcellular pathway across tracheal and jejunal epithelium (64,65). Furthermore, in vitro-formed IgE IC, when administered through the airways, are more potent than Ag alone in inducing airway inflammatory responses in mice previously sensitized with the Ag (66).…”
Section: Discussionmentioning
confidence: 99%
“…These cells can use FcεRI receptor for capturing IgE-complexed Ag. More interestingly, the sensitization can increase uptake of specific Ag via an endosomal transcellular pathway across tracheal and jejunal epithelium (64,65). Furthermore, in vitro-formed IgE IC, when administered through the airways, are more potent than Ag alone in inducing airway inflammatory responses in mice previously sensitized with the Ag (66).…”
Section: Discussionmentioning
confidence: 99%
“…Studies examining T cell activation in the GALT in response to OVA feeding have shown that T cell proliferation can be observed in both the MLN and the PP (31,32). Soluble Ags (such as OVA or HRP) can readily be taken up by epithelial cells (33)(34)(35)(36) and delivered to the MLN by DCs migrating from the lamina propria (28). In contrast, particulate Ags are preferentially taken up by M cells overlying the PP (37,38).…”
Section: Discussionmentioning
confidence: 99%
“…13,32 Evidence has been provided that transepithelial transport of antigen in sensitized rodents is both faster and of greater magnitude because of its protected transcytosis within enterocyte endosomes. 31 Subsequent to mast cell activation, a sec- ond phase of enhanced transepithelial transport of antigen occurs because of loosening of intercellular tight junctions allowing additional intact antigen to move through the paracellular spaces. Here, we confirmed by HRP flux that the antigen was transported across the epithelium, both more rapidly and in larger quantity, in sensitized stressed rats than in naïve controls or in rats exposed to sham stress.…”
Section: Discussionmentioning
confidence: 99%
“…We previously showed in sensitized rodents that epithelial permeability is specifically enhanced for the antigen to which the animal has been sensitized; 31 this phenomenon is due to interleukin (IL)-4-up-regulated expression of CD23 (low-affinity IgE receptor) on epithelial cells, binding IgE antigen, and transporting the complex via endosomes across the cell (transcellular pathway). 33,34 Antigen delivered to the lamina propria then activates mast cells, and released mediators act on epithelial receptors to further increase permeability by loosening intercellular tight junctions (paracellular pathway).…”
Section: Transepithelial Antigen Transportmentioning
confidence: 99%