Rapid synthesis of citrate-zinc substituted hydroxyapatite using the ultrasonication-microwave method

Zhong, Zhenyu; Qin, Jinli; Ma, Jun

doi:10.1016/j.ceramint.2017.07.029

Cited by 11 publications

(3 citation statements)

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“…For HAP sample without doping strontium, the adsorption peak at 1598 cm −1 was assigned to C=O stretching of amide I bands, which moved to 1593 cm −1 for Sr-HAP. The peak at 1412 cm −1 could be assigned to the carboxyl stretching vibrations of citrate groups [15]. The bands around 1030-1032, 602-604, 563-564 and 469-471 cm −1 were caused by the phosphate groups in HAP and Sr-HAP.…”

Section: Characterization Of Hap and Sr-hap Powdersmentioning

confidence: 95%

“…Bone contains approximate 2 wt% citrate and it was reported that citrate could bind strongly to the surface of HAP nanocrystals in bone, which was thought to prevent crystal thickening [13] and bridge the mineral platelets [14]. In addition, citrate was found to affect the ionic substitution in HAP during the synthesis [15,16]. Citrate could actively influence the mineralization process through stabilizing amorphous phase and controlling nanocrystal size [17].…”

Section: Introductionmentioning

confidence: 99%

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3D printing of strontium-doped hydroxyapatite based composite scaffolds for repairing critical-sized rabbit calvarial defects

et al. 2018

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In this study, strontium substituted hydroxyapatite (Sr-HAP) was synthesized using collagen type I and citrate as bi-templates and the obtained nanoparticles with high similarity to natural bone minerals were made into composite scaffolds with interconnected porous structure using a three-dimensional (3D) printing technique. A calcium deficient structure of HAP phase was caused by doping Sr which was verified by Fourier transform infrared, x-ray diffractometer, scanning electron microscopy and transmission electron microscopy. The Sr/(Sr + Ca) molar ratio in Sr-HAP nanoparticles was 5.8% estimated by EDX. Furthermore, both 3D printed scaffolds made of Sr-HAP and HAP had uniform porous structure and porosity of about 60%. Cell culturing indicated that MC3T3-E1 cells could adhere on the surface of the scaffolds and the strontium substitution could enhance cell adhesion, proliferation and alkaline phosphatase activity. The printed composite scaffolds were used to repair critical-sized rabbit calvarial defects with a diameter of 15 mm. The results showed that the Sr-HAP scaffolds had better osteogenic capability and stimulated more new bone formation within 12 weeks. It was suggested that these printed Sr-HAP composite scaffolds possessed high potential as candidates in the application of bone augmentation and regeneration.

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Section: Characterization Of Hap and Sr-hap Powdersmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

3D printing of strontium-doped hydroxyapatite based composite scaffolds for repairing critical-sized rabbit calvarial defects

et al. 2018

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“…Meanwhile, metallic ion substitution over the years has been found to boost the performance of ceramic materials. For instance, silicate-substituted calcium phosphate has been shown to enhance the bone-bonding ability of ceramics, whereas use of zinc, which is an important cofactor for many metallo-enzymes such as ALP and even IGF-2, has been reported to enhance the preosteoblast maturation and modulate the local immune response, − thereby conferring osteoinductive traits to the resulting ceramic.…”

Section: Discussionmentioning

confidence: 99%

Synergistic Effects of Silicon/Zinc Doped Brushite and Silk Scaffolding in Augmenting the Osteogenic and Angiogenic Potential of Composite Biomimetic Bone Grafts

Moses

Dey

Devi

et al. 2019

ACS Biomater. Sci. Eng.

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Cell instructive scaffolding platforms displaying synergistic effects by virtue of their chemical and physical cues have tremendous scope in modulating cell phenotype and thus improving the success of any graft. In this regard, we report here the development of Si- and Zn-doped brushite cement composited with silk scaffolding that hierarchically emulated the cancellous bone. The composite scaffolds fabricated exhibited an open porous network capable of enhanced osteoblast survival as attested by increased alkaline phosphatase activity and also sustaining osteoclast activity affirmed by tartrate resistant acid phosphatase staining. Moreover, the chemical cues presented by dissolutions products from the composite scaffold enabled the osteoblasts to secrete proangiogenic factors which favored better endothelial cell survival, confirmed through in vitro experiments. Moreover, the efficacy of these composite biomimetic scaffolds was validated in vivo in volumetric femur defects in rabbits, which revealed that these matrices influenced vascular cell infiltration and favored the formation of matured bony plate. Fluorochrome labeling studies and microtomography analysis revealed that at the end of three months, the implanted composite scaffolds had completely resorbed, leaving behind neo-osseous tissue and vouching for clinical translation of these composite matrices as viable and affordable bone-graft substitutes.

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Zn-doped hydroxyapatite in biomedical applications

2021

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Rapid synthesis of citrate-zinc substituted hydroxyapatite using the ultrasonication-microwave method

Cited by 11 publications

References 35 publications

3D printing of strontium-doped hydroxyapatite based composite scaffolds for repairing critical-sized rabbit calvarial defects

3D printing of strontium-doped hydroxyapatite based composite scaffolds for repairing critical-sized rabbit calvarial defects

Synergistic Effects of Silicon/Zinc Doped Brushite and Silk Scaffolding in Augmenting the Osteogenic and Angiogenic Potential of Composite Biomimetic Bone Grafts

Zn-doped hydroxyapatite in biomedical applications

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