Rapid spontaneous regression of multicentric infantile myofibromatosis in the posterior fossa and lumbar vertebra

Miwa, Takaki; Oi, Shizuo; Nonaka, Yuichiro; Tamogami, Ryo; Sasaki, Hidenao; Akiyama, Masaharu; Yuza, Yuki; Yokoi, Kentaro; Yokokawa, Yuichi; Ida, Hiroyuki

doi:10.1007/s00381-010-1306-8

Cited by 11 publications

(6 citation statements)

References 25 publications

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“…[ 26 ] Because spontaneous regression can be expected, the first choice of management is close observation. [ 8 ] However, in our case, we performed marginal excision of the mass and posterior instrumentation of L4 to S1 with left-sided posterolateral fusion of L4-5 because it had right facet joint involvement of L4-5 by pathologic fracture, resulting in lower back pain in patient, and infiltration to right L5-S1 neural foramen. On follow-up CT of postoperative 1 year and serial follow-up radiographs of postoperative 3 years, the osteolytic lesion showed gradually decreased size and sclerotic change which might have occurred due to bony remodeling without tumor recurrence, indicating benign lesion.…”

Section: Discussionmentioning

confidence: 95%

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Solitary myofibroma of the lumbar vertebra in young adult

Lee

Ha²,

Kang³

et al. 2017

Medicine

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Background:Solitary myofibroma of the spine is extremely rare, particularly among adults. To the best of our knowledge, only 3 cases affecting lumbar vertebrae have been reported in the English language literature. Of them, only 1 case was an adult case of solitary myofibroma affecting the L1 vertebra.Methods:We report a case of solitary myofibroma affecting the L5 vertebra in an 18-year-old man and the postoperative imaging of solitary myofibroma for the first time. Conventional radiographs demonstrated an expansile osteolytic lesion with thinned cortex and marginal sclerosis. Computed tomography (CT) showed a purely osteolytic expansile lesion with partial disappearance of thinned cortex. MRI of the lesion revealed an isointense signal on T1-weighted images, an inhomogeneous slightly hyperintense signal on T2-weighed images, and homogeneous avid enhancement with gadolinium.Results:Surgical excision was performed and the lesion was diagnosed as solitary myofibroma on pathological examination. One-year follow-up postoperative CT demonstrated decreased size of the osteolytic lesion with sclerotic change. Four-year follow-up postoperative MRI revealed complete resolution of the lesion replaced by normal fatty marrow.Conclusion:If a benign-looking expansile osteolytic lesion reveals a homogeneously isointense signal on T1-weighted image, inhomogeneous slightly hyperintense signal on T2-weighted image, and homogeneous avid enhancement with gadolinium, solitary myofibroma should be considered in the differential diagnosis of spine bone tumors. It can be resolved completely.

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Section: Discussionmentioning

confidence: 95%

“…Of them, 2 cases were neonate and infant cases of multicentric infantile myofibromatosis. [ 8 , 9 ] Only 1 case was an adult case of solitary myofibroma affecting the L1 vertebra. [ 10 ] In this report, we describe an extremely rare case of solitary myofibroma affecting the L5 vertebra of an 18-year-old man.…”

Section: Introductionmentioning

confidence: 99%

Solitary myofibroma of the lumbar vertebra in young adult

Lee

Ha²,

Kang³

et al. 2017

Medicine

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“…In the multicenter type, excision is required if a vital function is affected. Spontaneous regression has been described, which suggest that observation with close follow-up can be an option (23,24). Adjuvant chemotherapy has been described for the multicenter disease (25).…”

Section: Discussionmentioning

confidence: 99%

Infantile myofibromatosis of the iliac bone

Rosello

Rampal

Doria

et al. 2017

ccmbm

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SummaryIntroduction. Solitary infantile myofibromatosis (IM) of bone is a rare benign osseous tumor of childhood with low rate of recurrence. Well documented within the multicenter form, its solitary intraosseous location is less well described. Case report. We present a rare case of intraosseous myofibromatosis arising the iliac bone of a 11-year-old girl, who was operated at 2 months of life for a retroauricular subcutaneous MF with unbalanced translocation t(9;16).

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“…Spontaneous involution is common, and there has been no report of any case of sarcomatous degeneration. 4 …”

Section: Introductionmentioning

confidence: 99%

A misleading tumor: A rare form of infantile fibromatosis

Ouali

Berrada

Diallo

et al. 2023

SAGE Open Medical Case Reports

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Infantile fibromatosis is a rare mesenchymal disorder characterized by the fibrous proliferation of the skin, bone, muscle, and viscera. The clinical features vary from solitary to multicentric forms with similar pathological features. Although the tumor is histologically benign, it is a highly infiltrating lesion making the prognosis poor for patients with craniofacial involvement affection due to the major risk of nerve vascular and airway compression syndrome. The solitary form of infantile fibromatosis observed in the dermis, subcutis, or fibromatosis tends to occur predominantly in males and typically affects craniofacial deep soft tissues. We present a case of an unusual symptom presentation and a rarely observed location of a solitary fibromatosis form, affecting the muscle of the forearm and infiltrating the bone in a 12-year-old girl. Imaging findings were suggestive of rhabdomyosarcoma, but histopathology set the diagnosis of an infantile fibromatosis. The patient, then, received chemotherapy, and amputation was proposed due to the inextricability of this benign yet aggressive tumor, an option that was refused by her parents. We discuss through this article the clinical, radiological, and pathological features of this benign yet aggressive condition, the potential differential diagnosis, the prognosis, and treatment options substantiated with concrete examples from the literature.

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Rapid spontaneous regression of multicentric infantile myofibromatosis in the posterior fossa and lumbar vertebra

Cited by 11 publications

References 25 publications

Solitary myofibroma of the lumbar vertebra in young adult

Solitary myofibroma of the lumbar vertebra in young adult

Infantile myofibromatosis of the iliac bone

A misleading tumor: A rare form of infantile fibromatosis

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