Rapid Screen for Antiviral T‐Cell Immunity with Nanowire Electrochemical Biosensors

Nami, Mohsen; Han, Patrick; Hanlon, Douglas; Tatsuno, Kazuki; Weinhammer, Annika; Sobolev, Olga; Pitruzzello, Mary; Vassall, Aaron; Yosinski, Shari; Edelson, Richard L.; Reed, Mark A.

doi:10.1002/adma.202109661

Cited by 9 publications

(4 citation statements)

References 56 publications

(75 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This approach also holds promise for monitoring inflammatory responses in IBD. 51 Consequently, by combining different types of NWs with appropriate diagnostic technologies, significant advancements can be made in GI disease imaging, leading to improved diagnostic outcomes.…”

Section: Key Nps In Gi Diseases Imagingmentioning

confidence: 99%

Application of Nanoparticles in the Diagnosis of Gastrointestinal Diseases: A Complete Future Perspective

Yue¹,

Xu²,

Xu³

et al. 2023

IJN

View full text Add to dashboard Cite

The diagnosis of gastrointestinal (GI) diseases currently relies primarily on invasive procedures like digestive endoscopy. However, these procedures can cause discomfort, respiratory issues, and bacterial infections in patients, both during and after the examination. In recent years, nanomedicine has emerged as a promising field, providing significant advancements in diagnostic techniques. Nanoprobes, in particular, offer distinct advantages, such as high specificity and sensitivity in detecting GI diseases. Integration of nanoprobes with advanced imaging techniques, such as nuclear magnetic resonance, optical fluorescence imaging, tomography, and optical correlation tomography, has significantly enhanced the detection capabilities for GI tumors and inflammatory bowel disease (IBD). This synergy enables early diagnosis and precise staging of GI disorders. Among the nanoparticles investigated for clinical applications, superparamagnetic iron oxide, quantum dots, single carbon nanotubes, and nanocages have emerged as extensively studied and utilized agents. This review aimed to provide insights into the potential applications of nanoparticles in modern imaging techniques, with a specific focus on their role in facilitating early and specific diagnosis of a range of GI disorders, including IBD and colorectal cancer (CRC). Additionally, we discussed the challenges associated with the implementation of nanotechnology-based GI diagnostics and explored future prospects for translation in this promising field.

show abstract

Section: Key Nps In Gi Diseases Imagingmentioning

confidence: 99%

Application of Nanoparticles in the Diagnosis of Gastrointestinal Diseases: A Complete Future Perspective

Yue¹,

Xu²,

Xu³

et al. 2023

IJN

View full text Add to dashboard Cite

show abstract

“…Such an initiative is especially crucial in times like the pandemic, where there is an incentive for the rapid development of novel tools to quantify cellular immunity. For example, a recently described nanowire-based assay that promises rapid and accurate T cell quantification( Nami et al, 2022 ) or a skin test (similar to the tuberculin skin test) that has just received the greenlight to proceed with in-human trials (NCT05216510). This pandemic has also shown a lack of consensus among scientists and public health officers as to the best method of surveilling cellular immunity, unlike seroprevalence that was immediately monitored by the CDC.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

T cell immunity is key to the pandemic endgame: How to measure and monitor it

Schwarz

Mzoughi

Lozano‐Ojalvo

et al. 2022

Current Research in Immunology

View full text Add to dashboard Cite

“…The development of this technology has had a profound impact on diabetes management. 11 Unlike the rst generation, the second generation of biosensors (microbial, 12,13 immune, 14,15 enzyme immune and organelle sensors 16,17 ) consists of biomarkers adsorbed or covalently bound to the surface of the transducer. In contrast, the third generation of biosensors, which are currently being developed, are those in which biomarkers are directly immobilized to electronic components, thus bringing together biometric and electrical signal processing, i.e., eld-effect biosensors that combine system biotechnology and electronics.…”

Section: Introductionmentioning

confidence: 99%

Recent advances of biosensors on microneedles

Ma,

Zhou,

Gao

2023

Anal. Methods

View full text Add to dashboard Cite

show abstract

Rapid Screen for Antiviral T‐Cell Immunity with Nanowire Electrochemical Biosensors

Abstract: comparisons was calculated using unpaired t-test or two-way analysis of variance (ANOVA). Plots and histograms were created and analyzed in Prism (Prism v.9.3.1, GraphPad)

Cited by 9 publications

References 56 publications

Application of Nanoparticles in the Diagnosis of Gastrointestinal Diseases: A Complete Future Perspective

Application of Nanoparticles in the Diagnosis of Gastrointestinal Diseases: A Complete Future Perspective

T cell immunity is key to the pandemic endgame: How to measure and monitor it

Recent advances of biosensors on microneedles

Contact Info

Product

Resources

About