Rapid regeneration of enamel-like-oriented inorganic crystals by using rotary evaporation

Wang, Shengrui; Le, Zhang; Chen, Wendy; Jin, Huimin; Zhang, Ya; Wu, Leping; Shao, Hui; Fang, Zehui; He, Xiaoxue; Zheng, Shunli; Cao, Chris Ying; Wong, Hai Ming; Li, Quanli

doi:10.1016/j.msec.2020.111141

Cited by 16 publications

(16 citation statements)

References 70 publications

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“…In our previous study, we found that crystal growth was controlled by the organic template and affected by the characteristics of the substrate surface [ 27 ]. In the present study, the first synthesized fluorapatite crystal layer grew on the polydopamine-coated polyethylene plate but the second crystal layer grew on the polyelectrolyte matrix film coated crystal layer.…”

Section: Resultsmentioning

confidence: 99%

“…3B and C . Besides, the –COOH in GO chelates with free calcium ions to trigger the heterogeneous nucleation by the electrostatic interaction, which may prevent the release of free GO [ 27 ]. The biosafety of our synthesized material was therefore confirmed.…”

Section: Resultsmentioning

confidence: 99%

“…Recently, Yeom et al synthesized ZnO columnar nanocomposites with well-defined morphologies and patterns and a multilayered structure via the bottom-up LBL deposition of a polymeric matrix [ 21 ]. There is also evidence that evaporating the mineralization solution could speed up the process of crystal growth and help crystals self-assemble into oriented arrays [ 27 , 28 ]. Therefore, the evaporation-based, bottom-up and self-assembly method with LBL technique were used in the present study.…”

Section: Introductionmentioning

confidence: 99%

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An enamel-inspired bioactive material with multiscale structure and antibacterial adhesion property

Wong

Zhang

2022

Bioactive Materials

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Conventional dental materials lack of the hierarchical architecture of enamel that exhibits excellent intrinsic-extrinsic mechanical properties. Moreover, restorative failures frequently occur due to physical and chemical mismatch between artificial materials and native dental hard tissue followed by recurrent caries which is caused by sugar-fermenting, acidogenic bacteria invasion of the defective cite. In order to resolve the limitations of the conventional dental materials, the aim of this study was to establish a non-cell-based biomimetic strategy to fabricate a novel bioactive material with enamel-like structure and antibacterial adhesion property. The evaporation-based, bottom-up and self-assembly method with layer-by-layer technique were used to form a large-area fluorapatite crystal layer containing antibacterial components. The multilayered structure was constructed by hydrothermal growth of the fluorapatite crystal layer and highly conformal adsorption to the crystal surface of a polyelectrolyte matrix film. Characterization and mechanical assessment demonstrated that the synthesized bioactive material resembled the native enamel in chemical components, mechanical properties and crystallographic structure. Antibacterial and cytocompatibility evaluation demonstrated that this material had the antibacterial adhesion property and biocompatibility. In combination with the molecular dynamics simulations to reveal the effects of variables on the crystallization mechanism, this study brings new prospects for the synthesis of enamel-inspired materials.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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An enamel-inspired bioactive material with multiscale structure and antibacterial adhesion property

Wong

Zhang

2022

Bioactive Materials

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“…Previous studies showed that HA orientation grows at the substrate surface with the principle of lowest energy, preferentially randomly or perpendicularly to the substrate surface. 64 Therefore, how can HA be driven to overcome this least-energy advantage to grow parallel to the base? In addition to the stereochemical features of the collagen fibers themselves, as mentioned above, we hypothesize that the DAA molecules of the cross-linked collagen also have a slight influence on the arrangement of the HA crystals.…”

Section: Discussionmentioning

confidence: 99%

A Dopamine Acrylamide Molecule for Promoting Collagen Biomimetic Mineralization and Regulating Crystal Growth Direction

Wang

et al. 2021

ACS Appl. Mater. Interfaces

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The reconstruction of the intra/interfibrillar mineralized collagen microstructure is extremely important in biomaterial science and regeneration medicine. However, certain problems, such as low efficiency and long period of mineralization, are apparent, and the mechanism of interfibrillar mineralization is often neglected in the present literature. Thus, we propose a novel model of biomimetic collagen mineralization that uses molecules with the dual function of cross-linking collagen and regulating collagen mineralization to construct the intrafibrillar and interfibrillar collagen mineralization of the structure of mineralized collagen hard tissues. In the present study completed in vitro, N-2-(3,4-dihydroxyphenyl) acrylamide (DAA) is used to bind and cross-link collagen molecules and further stabilize the selfassembled collagen fibers. The DAA−collagen complex provides more affinity with calcium and phosphate ions, which can reduce the calcium phosphate/collagen interfacial energy to promote hydroxyapatite (HA) nucleation and accelerate the rate of collagen fiber mineralization. Besides inducing intrafibrillar mineralization, the DAA−collagen complex mineralization template can realize interfibrillar mineralization with the c-axis of the HA crystal on the surface of collagen fibers and between fibers that are parallel to the long axis of collagen fibers. The DAA−collagen complex, as a new type of mineralization template, may provide a new collagen mineralization strategy to produce a mineralized scaffold material for tissue engineering or develop bone-like materials.

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“…Current investigations into the mechanisms of amelogenesis have uncovered a diverse range of novel biomimetic strategies which the aim of reconstructing subsurface enamel lesions using remineralization processes. These strategies include positive ion selective membrane [20], direct calcium phosphate solution/paste mineralization [11,21,22], electrolytic precipitation [23], protein/peptide-induced mineralization [24][25][26][27][28] and nonprotein-induced mineralization [29][30][31][32][33]. All biomimetic strategies utilize an organic matrices template to control the nucleation, growth and features of HA crystals in order to regenerate enamel-like structures.…”

Section: Introductionmentioning

confidence: 99%

Cell-Free Biomimetic Mineralization Strategies to Regenerate the Enamel Microstructure

Zhang

Wong

2021

Crystals

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The distinct architecture of native enamel gives it its exquisite appearance and excellent intrinsic-extrinsic fracture toughening properties. However, damage to the enamel is irreversible. At present, the clinical treatment for enamel lesion is an invasive method; besides, its limitations, caused by the chemical and physical difference between restorative materials and dental hard tissue, makes the restorative effects far from ideal. With more investigations on the mechanism of amelogenesis, biomimetic mineralization techniques for enamel regeneration have been well developed, which hold great promise as a non-invasive strategy for enamel restoration. This review disclosed the chemical and physical mechanism of amelogenesis; meanwhile, it overviewed and summarized studies involving the regeneration of enamel microstructure in cell-free biomineralization approaches, which could bring new prospects for resolving the challenges in enamel regeneration.

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Rapid regeneration of enamel-like-oriented inorganic crystals by using rotary evaporation

Cited by 16 publications

References 70 publications

An enamel-inspired bioactive material with multiscale structure and antibacterial adhesion property

An enamel-inspired bioactive material with multiscale structure and antibacterial adhesion property

A Dopamine Acrylamide Molecule for Promoting Collagen Biomimetic Mineralization and Regulating Crystal Growth Direction

Cell-Free Biomimetic Mineralization Strategies to Regenerate the Enamel Microstructure

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