Rapid protocol for quantitative CMRO2 and CBF using PET and O-15 labelled compounds

Feasibility of mapping the tissue mass corrected bioscale of cerebral metabolic rate of oxygen consumption using 17-oxygen and 23-sodium MR imaging in a human brain at 9.4T

“…The model accounts for the fact that the 15 O signal measured by PET contains contributions from the metabolic water created as a byproduct of oxygen reduction to water (signal of interest), the 15 O gas dissolved in blood and bound to hemoglobin (confounding signal), and 15 O-labeled water recirculating in the blood (confounding signal). While small modifications to the original PET technique have been presented (Yee et al, 2006;Nobuyuki et al, 2004), the general approach and underlying mathematical model remain essentially unchanged. The short half-life (∼ 2 min) of the radioactive 15 O isotopes used for CMRO 2 mapping with PET necessitate on-site synthesis and rapid administration, which limits oxygen consumption mapping to a small number of sites worldwide.…”