Feasibility of mapping the tissue mass corrected bioscale of cerebral metabolic rate of oxygen consumption using 17-oxygen and 23-sodium MR imaging in a human brain at 9.4T

Atkinson, Ian C.; Thulborn, Keith R.

doi:10.1016/j.neuroimage.2010.02.056

Cited by 102 publications

(188 citation statements)

References 45 publications

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“…Some of the benefits are already clear: we have already seen progress in remotely probing local concentrations of fluorine, sodium, potassium and chlorine in human tissues (9)(10)(11)(12)(13)(14), in assessing bioenergetic conditions (15)(16)(17) and oxygen consumption (18) in vivo along with the advances in 9.4 T human MR (15,(19)(20)(21)(22)(23)(24). Pioneering reports on MR physics, radiofrequency (RF) power deposition considerations and novel RF antenna designs (25,26) spurred the installation of a 10.5 T whole-body MR system at the Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, USA (27).…”

Section: Introductionmentioning

confidence: 99%

Electrodynamics and radiofrequency antenna concepts for human magnetic resonance at 23.5 T (1 GHz) and beyond

Winter

Niendorf

2016

Magn Reson Mater Phy

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Materials and MethodsElectromagnetic field simulations (EMF) are performed in phantoms with average tissue simulants for dipole antennae using discrete frequencies (300MHz (7.0T) to 3GHz (70.0T)).To advance to a human setup EMF simulations are conducted in anatomical human voxel models of the human head using a 20-element dipole array operating at 1 GHz. ResultsOur results demonstrate that transmission fields suitable for 1 H MR of the human brain can be achieved at 1GHz. An increase in transmit channel density around the human head helps to enhance B1 + in the center of the brain. The calculated relative increase in specific absorption rate (SAR) at 23.5T vs. 7.0T was below 1.4 (in-phase phase setting) and 2.7 (circular polarized phase setting) for the dipole antennae array. ConclusionThe benefits of multi-channel dipole antennae at higher frequencies render MR at 23.5Tfeasible from an electrodynamic standpoint. This very preliminary finding opens the door on further explorations that might be catalyzed into a 20 Tesla class human MR system.2

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Section: Introductionmentioning

confidence: 99%

Electrodynamics and radiofrequency antenna concepts for human magnetic resonance at 23.5 T (1 GHz) and beyond

Winter

Niendorf

2016

Magn Reson Mater Phy

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“…The H 2 17 O concentration can be calculated using a technique established in cerebral applications [38]. However, challenges remain to accurately quantify MVO 2 using the 17 O-labelled contrast agent method: 1) sensitivity of the contrast detection is relatively low (10 -15% signal changes), particularly when the heart motion is not controlled well; 2) a comprehensive model has yet to be established for this intravenous injection method, although quantitative models for the inhalation methods in brain studies were reported previously [39,40].…”

Section: Cardiomyopathymentioning

confidence: 99%

Quantifying Myocardial Oxygenation with Cardiac Magnetic Resonance Imaging

Muccigrosso¹,

Zheng

2012

TOMIJ

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Myocardial ischemia, resulting from imbalance in myocardial oxygen supply and demand, can be quantitatively assessed by positron emission tomography (PET) with absolute measures of myocardial blood flow and oxygen consumption rate (MVO 2 ). Cardiac Magnetic Resonance (CMR) has notable advantages over PET, with no radiation, high spatial resolution, faster scan times, and excellent soft tissue contrast. We have developed and validated new quantitative CMR oximetry techniques, including measurements of hyperemic myocardial oxygen extraction fraction and MVO 2 through Fick's Law. These may lead to a new understanding of roles of myocardial microcirculation in myocardial ischemia. Other cardiac oximetry methods for directly quantifying MVO 2 with 17 O-labelled water are also under investigation. Quantitative CMR oximetry is a promising, non-invasive, non-radiation approach for exploring the myocardial metabolism's role in cardiac patients.

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“…Sodium imaging has a long history, with the principal applications in the brain [133][134][135][136][137][138], heart [139], kidney [140,141] and musculoskeletal system [142][143][144]. Phosphorus imaging has also been performed with UTE sequences [145,146].…”

Section: Other Nucleimentioning

confidence: 99%

“…Phosphorus imaging has also been performed with UTE sequences [145,146]. Oxygen-17 studies have been performed in the brain [135,137], and fluorine studies have begun [147].…”

Section: Other Nucleimentioning

confidence: 99%

The Agfa Mayneord lecture: MRI of short and ultrashortT₂andT₂* components of tissues, fluids and materials using clinical systems

Bydder¹

2011

BJR

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ABSTRACT. A variety of techniques are now available to directly or indirectly detect signal from tissues, fluids and materials that have short, ultrashort or supershort T 2 or T 2 * components. There are also methods of developing image contrast between tissues and fluids in the short T 2 or T 2 * range that can provide visualisation of anatomy, which has not been previously seen with MRI. Magnetisation transfer methods can now be applied to previously invisible tissues, providing indirect access to supershort T 2 components. Particular methods have been developed to target susceptibility effects and quantify them after correcting for anatomical distortion. Specific methods have also been developed to image the effects of magnetic iron oxide particles with positive contrast. Major advances have been made in techniques designed to correct for loss of signal and gross image distortion near metal. These methods are likely to substantially increase the range of application for MRI.

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Feasibility of mapping the tissue mass corrected bioscale of cerebral metabolic rate of oxygen consumption using 17-oxygen and 23-sodium MR imaging in a human brain at 9.4T

Cited by 102 publications

References 45 publications

Electrodynamics and radiofrequency antenna concepts for human magnetic resonance at 23.5 T (1 GHz) and beyond

Electrodynamics and radiofrequency antenna concepts for human magnetic resonance at 23.5 T (1 GHz) and beyond

Quantifying Myocardial Oxygenation with Cardiac Magnetic Resonance Imaging

The Agfa Mayneord lecture: MRI of short and ultrashortT₂andT₂* components of tissues, fluids and materials using clinical systems

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Feasibility of mapping the tissue mass corrected bioscale of cerebral metabolic rate of oxygen consumption using 17-oxygen and 23-sodium MR imaging in a human brain at 9.4T

Cited by 102 publications

References 45 publications

Electrodynamics and radiofrequency antenna concepts for human magnetic resonance at 23.5 T (1 GHz) and beyond

Electrodynamics and radiofrequency antenna concepts for human magnetic resonance at 23.5 T (1 GHz) and beyond

Quantifying Myocardial Oxygenation with Cardiac Magnetic Resonance Imaging

The Agfa Mayneord lecture: MRI of short and ultrashortT2andT2* components of tissues, fluids and materials using clinical systems

Contact Info

Product

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The Agfa Mayneord lecture: MRI of short and ultrashortT₂andT₂* components of tissues, fluids and materials using clinical systems