Rapid Progressive Glomerulonephritis in Patients With Familial Mediterranean Fever

Said, Riyad; Hamzeh, Yousef; Tarawneh, Musleh S.; Ei-Khateeb, Mohammed; Abdeen, Muafiq; Shaheen, Ahmad

doi:10.1016/s0272-6386(89)80176-3

Cited by 17 publications

(5 citation statements)

References 17 publications

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“…IgM nephropathy, IgA nephropathy, focal and diffuse proliferative glomerulonephritis, mesangiocapillary glomerulonephritis, and rapidly progressive glomerulonephritis have also been reported in patients with FMF [54,55,56]. It is not known whether the presence of nonamyloid glomerular diseases with FMF is coincidental or causal.…”

Section: Non-amyloid Glomerulopathiesmentioning

confidence: 99%

Familial Mediterranean fever

Bakkaloğlu

2003

Pediatric Nephrology

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Familial Mediterranean fever (FMF) is the most frequent periodic syndrome characterized by recurrent attacks of polyserositis. Fever, abdominal pain, chest pain, and arthritis/arthralgia are the leading symptoms. It is an autosomal recessive disorder, which primarily affects Jewish, Armenian, Turkish, and Arab populations. The FMF gene ( MEFV) has recently been cloned to chromosome 16p, which encodes pyrin. Genotype-phenotype correlation is not well established. Amyloidosis is the most severe complication of FMF. The SAA1-alpha/alpha genotype was associated with an increased risk of amyloidosis. Colchicine treatment not only decreases the frequency and severity of attacks, but also prevents amyloidosis. Certain vasculitides, namely Henoch-Schonlein purpura and polyarteritis nodosa, are more frequent among FMF patients.

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Section: Non-amyloid Glomerulopathiesmentioning

confidence: 99%

Familial Mediterranean fever

Bakkaloğlu

2003

Pediatric Nephrology

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“…Non-amyloid renal involvement has also been described, although a casual association with FMF cannot be verified [ 3 ]. It includes IgA nephropathy, IgM nephropathy, membranoproliferative glomerulonephritis and rapidly progressive crescentic glomerulonephritis [ 8 , 9 ], one case of the later responding to pulse methylprednisolone and cyclophosphamide treatment [ 9 ]. Both renal biopsies of our patient did not show any amyloid or immune deposits, and to the best of our knowledge it is the first case of FSGS described in a patient with FMF.…”

Section: Discussionmentioning

confidence: 99%

Fever of unknown origin in a haemodialysis patient: a late diagnosis requiring a novel treatment

Pateinakis

Katsaounou

Meimaridou

et al. 2014

Clinical Kidney Journal

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“…PAN is an immune-complex mediated vasculitis of small and medium-sized arteries with a characteristic histopathology: transparietal acute inflammation and fibrinoid necrosis. Although immune complexes have been detected in 50% of patients with FMF, 25 it may be speculated that the pathogenesis of FMF-related PAN and the acute attacks of serositis have a similar mechanism. It has been proposed that in FMF any minor stimulus leads to an uncontrolled inflammatory reaction with complement activation, due to absence of an inhibitor of C5a [14][15][16][17][18] and/or excessive TNF release.…”

Section: Discussionmentioning

confidence: 99%