Familial mediterranean fever and acute myocardial infarction secondary to coronary vasculitis

Serrano, Raisa Yolanda Mariño; Martínez, M; Andrés, Ana; Morales, J. M.; Samartín, Raúl Coma

doi:10.1046/j.1365-2559.1998.00462.x

Cited by 26 publications

(12 citation statements)

References 19 publications

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“…Importantly, recent studies with cardiovascular imaging techniques identified signs of diastolic dysfunction and microvascular coronary pathology which were correlated with elevated levels of CRP during attack-free period [31,32]. Clinical significance of coronary pathology in FMF was also highlighted in a few previous reports of coronary vasculitis, transient left bundle branch block and MI associated with inflammation in FMF [33][34][35].…”

Section: Fmf As a Low-grade Inflammatory Disordermentioning

confidence: 91%

Familial Mediterranean Fever as an Emerging Clinical Model of Atherogenesis Associated with Low-Grade Inflammation

Yüksel¹,

Ayvazyan²,

Gasparyan³

2010

TOCMJ

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Numerous inflammatory and innate immune pathways are involved in atherogenesis. Elaboration of clinical models of inflammation-induced atherogenesis may further advance our knowledge of multiple inflammatory pathways implicated in atherogenesis and provide a useful tool for cardiovascular prevention. Familial Mediterranean fever (FMF) is a chronic inflammatory disorder with profiles of inflammatory markers close to that seen in the general population. In a few recent studies, it has been shown that endothelial dysfunction, increased atherosclerotic burden and activation of platelets accompany attack-free periods of FMF. Colchicine is proved to be useful in suppression of inflammation in FMF. Preliminary basic and clinical studies suggest that this relatively safe drug may be useful for cardiovascular protection in patients with FMF and in the general population. Multinational prospective studies are warranted to further elaborate clinical model of inflammation-induced atherosclerosis associated with FMF.

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Section: Fmf As a Low-grade Inflammatory Disordermentioning

confidence: 91%

Familial Mediterranean Fever as an Emerging Clinical Model of Atherogenesis Associated with Low-Grade Inflammation

Yüksel¹,

Ayvazyan²,

Gasparyan³

2010

TOCMJ

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“…Furthermore, over the past few years, several reports have been published, linking subclinical inflammation with hypercoagulopathy and thrombosis in FMF [46][47][48][49][50][51]. It has been reported that persistent inflammation in FMF might cause coronary vasculitis, transient left bundle branch block, and MI [52,53]. Interestingly, thrombosis of the cerebral arteries causing stroke was also reported in a patient with FMF having M694V homozygosity and extremely high acute phase response [49].…”

Section: Pioneering Reports About Fmf-vasculitis Associationmentioning

confidence: 99%

Coexistence of vasculitides with Familial Mediterranean Fever

Aksu

Keser

2011

Rheumatol Int

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Familial Mediterranean fever (FMF) is the most common autoinflammatory disease characterized by recurrent self-limited attacks of fever accompanied with peritonitis, pleuritis, or arthritis. FMF may coexist with various systemic inflammatory diseases including vasculitides, spondyloarthritis, multiple sclerosis, and inflammatory bowel disease. Among these coexistences, this review concentrates on vasculitic disorders, with the aim of increasing the awareness of FMF-vasculitis association. This association does not merely show a coincidentally increased frequency of vasculitic disorders in FMF; rather, it seems that FMF patients might be at increased risk of developing vasculitis. Indeed, as also suggested by some authors, vasculitis might be an essential feature of FMF. Among the vasculitic disorders reported to be associated with FMF, Henoch-Schönlein purpura, and classical polyarteritis nodosa come the first, possibly followed up by protracted febrile myalgia. There is also an ongoing debate whether Behçet's disease (BD) more frequently seen in FMF than expected by chance alone. In this review, the associations of various vasculitic disorders with FMF and the possible pathogenic mechanisms underlying these associations, as well as the frequencies and clinical significances of FMF-related MEFV mutations in various vasculitides including BD, are discussed in the context of the available data.

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“…We found 2 case reports of myocardial infarction occurring in patients with FMF [ 21 , 22 ]. A third case is included in a study on aetiology of acute corornary syndrome under the age of 30 [ 23 ].…”

Section: Resultsmentioning

confidence: 99%

Autoinflammatory diseases: a possible cause of thrombosis?

Regina¹,

Orlandini²,

Manna

2015

Thrombosis J

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Autoinflammatory diseases are a group of disorders due to acquired or hereditary disfunction of innate immune system and characterized by systemic or localized manifestations. The prototype is Familial Mediterranean Fever, a monogenic hereditary disorder, whose causing gene (MeFV gene) was identified in 1997 and opened the way to a new fascinanting chapter of rheumatology. A growing body of monogenic and poligenic autoinflammatory disorders has been described since then.Arterial and venous thrombosis is a common medical problem, with significant morbidity and mortality. Strong evidences from basic research and clinical epidemiological studies support the theory that inflammation and thrombosis can be associated.Because of their recurrent/chronic inflammatory nature, autoinflammatory diseases are a putative cause of thrombotic manifestations. In the present work, we reviewed the available evidences about monogenic autoinflammatory disorders, complicated by thrombotic manifestations.

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Familial mediterranean fever and acute myocardial infarction secondary to coronary vasculitis

Abstract: The histopathological findings of the vasculitis were not in keeping with PAN. We postulated that the pathogenesis of vasculitis in FMF is different from that of the classic PAN and might be similar to the mechanism of the serosal inflammation.

Cited by 26 publications

References 19 publications

Familial Mediterranean Fever as an Emerging Clinical Model of Atherogenesis Associated with Low-Grade Inflammation

Familial Mediterranean Fever as an Emerging Clinical Model of Atherogenesis Associated with Low-Grade Inflammation

Coexistence of vasculitides with Familial Mediterranean Fever

Autoinflammatory diseases: a possible cause of thrombosis?

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