Rapid, presumptive identification of seed-based toxins using direct analysis in real time mass spectrometry (DART-MS) and its variants

Sisco, Edward; Damaso, Natalie; Robinson, Elizabeth L.; Robertson, James; Forbes, Thomas P.

doi:10.1016/j.scijus.2021.12.004

Cited by 5 publications

(4 citation statements)

References 32 publications

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“…Finally, DART‐MS in particular has been applied to a range of forensically relevant sample types. This technique has been demonstrated in the analysis of sexual lubricants to evaluate storage conditions for sexual assault evidence, 79 the analysis of animal products to battle illegal trading, 80,81 polymeric carpet fibres for material identification 82 and seed‐based toxins encountered in cases of poisoning 83 . Gao et al.…”

Section: Applications Of Ambient Ionization Mass Spectrometrymentioning

confidence: 99%

“…This technique has been demonstrated in the analysis of sexual lubricants to evaluate storage conditions for sexual assault evidence, 79 the analysis of animal products to battle illegal trading, 80,81 polymeric carpet fibres for material identification 82 and seed-based toxins encountered in cases of poisoning. 83 Gao et al combined REIMS with multivariate analysis to differentiate between leather products sourced from different animals, a method that would be beneficial in leather product testing and authenticity confirmation. 84…”

Section: Forensics and Securitymentioning

confidence: 99%

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Applications of ambient ionization mass spectrometry in 2021: An annual review

Rankin‐Turner

Reynolds

Turner

et al. 2022

Analytical Science Advances

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Ambient ionization mass spectrometry (AIMS) has revolutionized the field of analytical chemistry, enabling the rapid, direct analysis of samples in their native state. Since the inception of AIMS almost 20 years ago, the analytical community has driven the further development of this suite of techniques, motivated by the plentiful advantages offered in addition to traditional mass spectrometry. Workflows can be simplified through the elimination of sample preparation, analysis times can be significantly reduced and analysis remote from the traditional laboratory space has become a real possibility. As such, the interest in AIMS has rapidly spread through analytical communities worldwide, and AIMS techniques are increasingly being integrated with standard laboratory operations. This annual review covers applications of AIMS techniques throughout 2021, with a specific focus on AIMS applications in a number of key fields of research including disease diagnostics, forensics and security, food safety testing and environmental sciences. While some new techniques are introduced, the focus in AIMS research is increasingly shifting from the development of novel techniques toward efforts to improve existing AIMS techniques, particularly in terms of reproducibility, quantification and ease-of-use.

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Section: Applications Of Ambient Ionization Mass Spectrometrymentioning

confidence: 99%

Section: Forensics and Securitymentioning

confidence: 99%

Applications of ambient ionization mass spectrometry in 2021: An annual review

Rankin‐Turner

Reynolds

Turner

et al. 2022

Analytical Science Advances

View full text Add to dashboard Cite

show abstract

“…11,12 Compared with traditional mass spectrometry technology, DART ion source works under atmospheric pressure, which brings in the advantages of simplifying or even eliminating sample pretreatment, environmentalfriendliness, simple operation, and rapid analysis. [13][14][15] Nie et al 16 Compared with existing methods, DART can ionize the compounds in a few seconds. Furthermore, it is an energy-efficient, high-throughput, and green method for the ionization of analytes.…”

Section: Introductionmentioning

confidence: 99%

“…Direct analysis in real time (DART) is a nonsurface contact analytical/ionized mass spectrometry technique 11,12 . Compared with traditional mass spectrometry technology, DART ion source works under atmospheric pressure, which brings in the advantages of simplifying or even eliminating sample pretreatment, environmental‐friendliness, simple operation, and rapid analysis 13–15 . Nie et al 16 used DART‐MS and liquid chromatography–quadrupole time‐of‐flight mass spectrometry (LC–Q‐TOF‐MS) for comparative experiments on 11 NPS.…”

Section: Introductionmentioning

confidence: 99%

Direct analysis in real‐time tandem mass spectrometry method for the rapid screening of 11 new psychoactive substances in blood and urine

Wang

Zhang³

et al. 2023

Rapid Comm Mass Spectrometry

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RationaleWith the continuous renewal of new psychoactive substances (NPS), the abuse of NPS has seriously harmed social security and public safety. The number of deaths from the abuse of NPS is increasing year by year. Therefore, there is an immediate need to develop an effective method for detecting NPS.MethodsDirect analysis in real‐time tandem mass spectrometry (DART‐MS/MS) was used to detect 11 NPS in blood and urine. The temperature of the ion source was optimized and set to 400°C. The mixture solvent of acetonitrile/methanol (4:1, v/v) was used as the precipitant. SKF‐525 (2‐(diethylamino)ethyl 2,2‐diphenylpentanoate) was selected as the internal standard for quantification. After the pretreatment of the analytes in blood or urine, the supernatant was prepared for instrumental analysis.ResultsThe results indicated that the correlation coefficients (r2) of all analytes ranged from 0.99 to 1 in the linear range. The recoveries of 11 analytes at three spiked levels ranged between 83.4% and 110.4% in blood and between 81.7% and 108.5% in urine. The matrix effects of 11 analytes ranged between 79.5% and 109.5% in blood and between 85.0% and 109.4% in urine. The relative standard deviations of intra‐day and inter‐day precisions and repeatability were lower than 12.4%, 14.1%, and 14.3% in blood and lower than 11.4%, 13.9%, and 14.3% in urine, respectively.ConclusionThe method established for the detection of 11 NPS could meet the needs for the rapid screening of NPS samples. The DART‐MS/MS method has the advantages of being efficient, fast, and green. Therefore, it may become a promising technology for the detection of NPS in the future.

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Ambient ionisation mass spectrometry for drug and toxin analysis: A review of the recent literature

Henderson,

Heaney,

Rankin‐Turner

2024

Drug Testing and Analysis

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Ambient ionisation mass spectrometry (AIMS) is a form of mass spectrometry whereby analyte ionisation occurs outside of a vacuum source under ambient conditions. This enables the direct analysis of samples in their native state, with little or no sample preparation and without chromatographic separation. The removal of these steps facilitates a much faster analytical process, enabling the direct analysis of samples within minutes if not seconds. Consequently, AIMS has gained rapid popularity across a diverse range of applications, in particular the analysis of drugs and toxins. Numerous fields rely upon mass spectrometry for the detection and identification of drugs, including clinical diagnostics, forensic chemistry, and food safety. However, all of these fields are hindered by the time‐consuming and laboratory‐confined nature of traditional techniques. As such, the potential for AIMS to resolve these challenges has resulted in a growing interest in ambient ionisation for drug and toxin analysis. Since the early 2000s, forensic science, diagnostic testing, anti‐doping, pharmaceuticals, environmental analysis and food safety have all seen a marked increase in AIMS applications, foreshadowing a new future for drug testing. In this review, some of the most promising AIMS techniques for drug analysis will be discussed, alongside different applications of AIMS published over a 5‐year period, to provide a summary of the recent research activity for ambient ionisation for drug and toxin analysis.

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Rapid, presumptive identification of seed-based toxins using direct analysis in real time mass spectrometry (DART-MS) and its variants

Cited by 5 publications

References 32 publications

Applications of ambient ionization mass spectrometry in 2021: An annual review

Applications of ambient ionization mass spectrometry in 2021: An annual review

Direct analysis in real‐time tandem mass spectrometry method for the rapid screening of 11 new psychoactive substances in blood and urine

Ambient ionisation mass spectrometry for drug and toxin analysis: A review of the recent literature

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