Rapid, microwave-assisted thermal polymerization of poly(ethylene glycol) diacrylate-supported ionogels

Visentin, Adam F.; Dong, Tingyi; Poli, Jonathan A; Panzer, Matthew J.

doi:10.1039/c4ta00907j

Cited by 24 publications

(13 citation statements)

References 44 publications

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“…The purpose of this study was to prepare a chitosan/polyvinyl alcohol/AgNPs gels matrix without using any reducer. Therefore, microwave irradiation, which could crosslink polymer [33], was employed in this investigation. The success of AgNPs formation was visually confirmed by the colour of the gels and the UV-Vis spectra.…”

Section: Characterization Of Cs/pva-agnps Hydrogelsmentioning

confidence: 99%

Microwave-Assisted Synthesis of Chitosan/Polyvinyl Alcohol Silver Nanoparticles Gel for Wound Dressing Applications

Hiệp

Huynh

Niem

et al. 2016

International Journal of Polymer Science

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The purpose of this study was to fabricate chitosan/poly(vinyl alcohol)/Ag nanoparticles (CPA) gels with microwave-assistance for skin applications. Microwave irradiation was employed to reduce silver ions to silver nanoparticles and to crosslink chitosan (CS) with polyvinyl alcohol (PVA). The presence of silver nanoparticles in CPA gels matrix was examined using UV-Vis spectroscopy, transmission electron microscopy, and X-ray diffraction. The interaction of CS and PVA was analysed by Fourier transform infrared spectroscopy. The release of silver ions was determined by atomic absorption spectrometry. The antimicrobial properties of CPA gels againstP. aeruginosaandS. aureuswere investigated using agar diffusion method. Finally, the biocompatibility and wound-healing ability of the gels were studied using fibroblast cells (in vitro) and mice models (in vivo). In conclusion, the results showed that CPA gels were successfully fabricated using microwave irradiation method. These gels can be applied to heal an open wound thanks to their antibacterial activity and biocompatibility.

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Section: Characterization Of Cs/pva-agnps Hydrogelsmentioning

confidence: 99%

Microwave-Assisted Synthesis of Chitosan/Polyvinyl Alcohol Silver Nanoparticles Gel for Wound Dressing Applications

Hiệp

Huynh

Niem

et al. 2016

International Journal of Polymer Science

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“…These absorption bands were clearly observed in the spectra of all the formulations before and after 3D printing, indicating the presence of the drug, and no interactions were seen between dexamethasone and the photopolymers. For comparison, the spectrum of PEGDA is also included, showing its distinct peaks at 1722 cm −1 (C=O stretching), 1633 cm −1 (C=C stretching), 1408 cm −1 and 810 cm −1 (CH 2 =CH) [ 75 , 76 ]. After 3D printing, these peaks at 1633 cm −1 , 1408 cm −1 and 810 cm −1 disappeared because of the conversion of C=C bonds to C–C bonds via photocrosslinking [ 51 , 77 , 78 ].…”

Section: Resultsmentioning

confidence: 99%

3D Printed Punctal Plugs for Controlled Ocular Drug Delivery

Awwad

Díaz-Gómez

et al. 2021

Pharmaceutics

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Dry eye disease is a common ocular disorder that is characterised by tear deficiency or excessive tear evaporation. Current treatment involves the use of eye drops; however, therapeutic efficacy is limited because of poor ocular bioavailability of topically applied formulations. In this study, digital light processing (DLP) 3D printing was employed to develop dexamethasone-loaded punctal plugs. Punctal plugs with different drug loadings were fabricated using polyethylene glycol diacrylate (PEGDA) and polyethylene glycol 400 (PEG 400) to create a semi-interpenetrating network (semi-IPN). Drug-loaded punctal plugs were characterised in terms of physical characteristics (XRD and DSC), potential drug-photopolymer interactions (FTIR), drug release profile, and cytocompatibility. In vitro release kinetics of the punctal plugs were evaluated using an in-house flow rig model that mimics the subconjunctival space. The results showed sustained release of dexamethasone for up to 7 days from punctal plugs made with 20% w/w PEG 400 and 80% w/w PEGDA, while punctal plugs made with 100% PEGDA exhibited prolonged releases for more than 21 days. Herein, our study demonstrates that DLP 3D printing represents a potential manufacturing platform for fabricating personalised drug-loaded punctal plugs with extended release characteristics for ocular administration.

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“…Polymerized acrylate hydrogel was confirmed by an FT‐IR study (Figure B), which showed absence of CH 2 CH bonds at 1407 and 809 cm −1 , highlighting consumption of free acrylate group in the polymerized thread‐like structures . Also, decrease in relative peak intensity of carbonyl group (CO) at 1720 cm −1 (monomer), and associated peak shifting from 1720 to 1728 cm −1 , confirmed acrylate polymerization .…”

mentioning

confidence: 77%

Thread‐Like Radical‐Polymerization via Autonomously Propelled (TRAP) Bots

2019

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Micromotor‐mediated synthesis of thread‐like hydrogel microstructures in an aqueous environment is presented. The study utilizes a catalytic micromotor assembly (owing to the presence of a Pt layer), with an on‐board chemical reservoir (i.e., polymerization mixture), toward thread‐like radical‐polymerization via autonomously propelled bots (i.e., TRAP bots). Synergistic coupling of catalytically active Pt layer, together with radical initiators (H2O2 and FeCl3 (III)), and PEGDA monomers preloaded into the TRAP bot, results in the polymerization of monomeric units into elongated thread‐like hydrogel polymers coupled with self‐propulsion. Interestingly, polymer generation via TRAP bots can also be triggered in the absence of hydrogen peroxide for cellular/biomedical application. The resulting polymeric hydrogel microstructures are able to entrap living cells (NIH 3T3 fibroblast cells), and are easily separable via a centrifugation or magnetic separation (owing to the presence of a Ni layer). The cellular biocompatibility of TRAP bots is established via a LIVE/DEAD assay and MTS cell proliferation assay (7 days observation). This is the first study demonstrating real‐time in situ hydrogel polymerization via an artificial microswimmer, capable of enmeshing biotic/abiotic microobjects in its reaction environment, and lays a strong foundation for advanced applications in cell/tissue engineering, drug delivery, and cleaner technologies.

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Rapid, microwave-assisted thermal polymerization of poly(ethylene glycol) diacrylate-supported ionogels

Cited by 24 publications

References 44 publications

Microwave-Assisted Synthesis of Chitosan/Polyvinyl Alcohol Silver Nanoparticles Gel for Wound Dressing Applications

Microwave-Assisted Synthesis of Chitosan/Polyvinyl Alcohol Silver Nanoparticles Gel for Wound Dressing Applications

3D Printed Punctal Plugs for Controlled Ocular Drug Delivery

Thread‐Like Radical‐Polymerization via Autonomously Propelled (TRAP) Bots

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