Rapid microsample analysis of imipramine and desipramine by reversed-phase high-performance liquid chromatography with ultraviolet detection

Yoo, Sun Dong; Holladay, John W.; Fincher, Timothy K.; Dewey, Michael J.

doi:10.1016/0378-4347(95)00084-v

Cited by 22 publications

(12 citation statements)

References 17 publications

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“…Samples containing relatively high levels of metoclopramide [13][14][15], hydrochlorothiazide [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33], imipramine [34][35][36][37][38][39][40][41][42][43][44][45] and diclofenac potassium [46][47][48][49][50][51][52][53][54][55][56][57][58] can be analysed using UV detection. Although, these methods did not present sufficient accuracy, especially at concentrations below 10 ng/ml.…”

Section: Introductionmentioning

confidence: 99%

Sensitive quantification of chosen drugs by reversed-phase chromatography with electrochemical detection at a glassy carbon electrode

Chmielewska

Konieczna

Plenis

et al. 2006

Journal of Chromatography B

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Section: Introductionmentioning

confidence: 99%

Sensitive quantification of chosen drugs by reversed-phase chromatography with electrochemical detection at a glassy carbon electrode

Chmielewska

Konieczna

Plenis

et al. 2006

Journal of Chromatography B

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“…In the last 10 years, only a few procedures have been developed to determine imipramine and desipramine using HPLC with UV (Hilberg et al, 1999;Theurillat and Thormann, 1998;Tanaka et al, 1997;Yoo et al, *Correspondence to: J. Esteve-Romero, Àrea de Química Analítica, Universitat Jaume I, Campus Riu Sec, Av. de Vicent Sos Baynat, s/n 12071 Castelló, Spain.…”

Section: Introductionmentioning

confidence: 99%

“…E-mail: estevej@exp.uji.es 1995; Goldnik et al, 1991;Segatti et al, 1991) or electrochemical (Ivandini et al, 2002;Koyama et al, 1993;Bouquet et al, 1992;Foglia et al, 1991) detection. In all cases, the procedure requires prior extraction and in most of them an internal standard is used (Theurillat and Thormann, 1998;Yoo et al, 1995;Goldnik et al, 1991;Segatti et al, 1991;Koyama et al, 1993;Bouquet et al, 1992;Foglia et al, 1991). The columns used were C 18 (Theurillat and Thormann, 1998;Yoo et al, 1995;Koyama et al, 1993;Foglia et al, 1991), C 8 (Tanaka et al, 1997;Segatti et al, 1991) and cyano (Hilberget al, 1999;Foglia et al, 1991).…”

Section: Introductionmentioning

confidence: 99%

“…In all cases, the procedure requires prior extraction and in most of them an internal standard is used (Theurillat and Thormann, 1998;Yoo et al, 1995;Goldnik et al, 1991;Segatti et al, 1991;Koyama et al, 1993;Bouquet et al, 1992;Foglia et al, 1991). The columns used were C 18 (Theurillat and Thormann, 1998;Yoo et al, 1995;Koyama et al, 1993;Foglia et al, 1991), C 8 (Tanaka et al, 1997;Segatti et al, 1991) and cyano (Hilberget al, 1999;Foglia et al, 1991). Moreover, the mobile phases employed in conventional HPLC usually require a high percentage of organic solvent (30-60%) to elute these compounds.…”

Section: Introductionmentioning

confidence: 99%

“…Ternary mobile phase with methanolacetonitrile-phosphate is also used to determine the two compounds. Sometimes the addition of anamine is useful to increase the efficiencies (Theurillat and Thormann, 1998;Yoo et al, 1995).…”

Section: Introductionmentioning

confidence: 99%

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Therapeutic monitoring of imipramine and desipramine by micellar liquid chromatography with direct injection and electrochemical detection

Bose¹,

Martinavarro-Domı́nguez²,

Gil-Agustı́³

et al. 2004

Biomedical Chromatography

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A micellar liquid chromatographic (MLC) procedure was developed for the clinical monitoring of imipramine and its active metabolite, desipramine. The determination of these highly hydrophobic substances was carried out after direct injection of the serum samples using a mobile phase composed of 0.15 m SDS--6% (v/v) pentanol buffered at pH 7, pumped at 1.5 mL/min into a C(18) column (250 x 4.6 mm), and electrochemical detection at 650 mV. Using this MLC method, calibration was linear (r > 0.995) and the limits of detection (ng/mL) were 0.34 and 0.24 for imipramine and desipramine, respectively. Repeatabilities and intermediate precision were tested at three different concentrations in the calibration range and a CV (%) below 2.2 was obtained. In this MLC procedure, the serum is determined without treatment, thus allowing repeated serial injections without changes in retention factors, and reducing the time and consumables required to carry out the pretreatment process. The assay method can be applied to the routine determination of serum imipramine and its metabolite in therapeutic drug monitoring.

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Imipramine-Induced c-Fos Expression in the Medial Prefrontal Cortex is Decreased in the ACTH-Treated Rats

Suemaru

Kitamura

et al. 2013

J Biochem Mol Toxicol

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Previous studies have shown that the antidepressive-like effect of tricyclic antidepressants is blocked by repeated treatments with adrenocorticotropic hormone (ACTH). However, little is known about the neuroanatomy underlying the mechanism of the imipramine treatment-resistant depression model. In the present study, first experimental evidence showed no significant difference of the serum imipramine concentrations between the saline and ACTH-treated rats. In further study, imipramine produced significant increases in the c-Fos expression in the medial prefrontal cortex (mPFC), the dentate gyrus of the hippocampus (DGH), and the central nucleus of the amygdala (CeA), in rats repeatedly treated with saline. The imipramine-increased c-Fos immunoreactivity was suppressed in the mPFC of rats repeatedly treated with ACTH. However, there was no significant difference in c-Fos expression in the DGH and CeA between ACTH- and saline-treated rats. These results suggest that the mPFC is maybe involved in effects of the imipramine in the ACTH-treated rats.

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Rapid microsample analysis of imipramine and desipramine by reversed-phase high-performance liquid chromatography with ultraviolet detection

Cited by 22 publications

References 17 publications

Sensitive quantification of chosen drugs by reversed-phase chromatography with electrochemical detection at a glassy carbon electrode

Sensitive quantification of chosen drugs by reversed-phase chromatography with electrochemical detection at a glassy carbon electrode

Therapeutic monitoring of imipramine and desipramine by micellar liquid chromatography with direct injection and electrochemical detection

Imipramine-Induced c-Fos Expression in the Medial Prefrontal Cortex is Decreased in the ACTH-Treated Rats

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