Rapid Metabolism of Phenytoin A Method of Calculating Proper Dosage

Hawkins, David; Ludden, Thomas M.; Hoffman, Steven F.; Allen, John P.

doi:10.1001/archneur.1979.00500380079011

Cited by 3 publications

(2 citation statements)

References 10 publications

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“…Hawkins et al described a case of a 48 -year -old man who was a rapid metabolizer and required 650 mg of phenytoin daily and experienced no phenytoin side effects (69) . Hawkins et al described a case of a 48 -year -old man who was a rapid metabolizer and required 650 mg of phenytoin daily and experienced no phenytoin side effects (69) .…”

Section: Miscellaneous Factors Affecting Therapeutic Drug Monitoring mentioning

confidence: 99%

Interference in Immunoassays Used for Monitoring Anticonvulsants and the Usefulness of Monitoring Free Anticonvulsants

Dasgupta

2012

Resolving Erroneous Reports in Toxicology and Therapeutic Drug Monitoring

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Section: Miscellaneous Factors Affecting Therapeutic Drug Monitoring mentioning

confidence: 99%

Interference in Immunoassays Used for Monitoring Anticonvulsants and the Usefulness of Monitoring Free Anticonvulsants

Dasgupta

2012

Resolving Erroneous Reports in Toxicology and Therapeutic Drug Monitoring

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“…The present article reports the results of three comparative analyses, designated Study A, Study B and Study C, which aim to establish which method is to be preferred for use in Cases A, B and C, respectively. All the kinetic data examined in our studies have been obtained from six articles (10,(12)(13)(14)(15)(16), recently published in the literature.…”

mentioning

confidence: 99%

Comparative Analysis of the Pharmacokinetic Techniques Available for Individualizing Phenytoin Dosage

Messori¹,

Zaccara²,

Valenza³

et al. 1983

J Clin Pharm Ther

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SUMMARY Over the past few years, numerous pharmacokinetic techniques based on Michaelis‐Menten principles have been proposed to individualize PHT dosage and predict plasma levels. The choice of one of these techniques for clinical use depends on the number of steady state concentration‐versus‐dose (Css‐D) data pairs that are known in the patient for whom the predictive technique is to be applied. The most frequent clinical situations in which these predictions are made can be divided into three groups for each patient considered—Case A: only one previous Css‐D data pair is known; Case B: two previous Css‐D data pairs are known; Case C: three previous Css‐D data pairs are known. Of the available techniques that can be applied in case A, we compared the population clearance (PC) method and the Bayesian feedback (BF) method. The procedure for comparing the predictive capabilities of these methods was very similar to that adopted in a recent report by Vozeh et al. Our findings showed that the PC method should be preferred for clinical use under this circumstance. Two predictive techniques suitable for use in Case B (BF and Mullen & Foster methods) were compared. In this case, the BF method was shown to be more accurate. As regards Case C, three pharmacokinetic techniques were compared: the Mullen and Foster method, the iterative least‐squares (ILS) technique, and the BF method. The ILS technique was found to be the most accurate in this case. Finally, we describe a programmable calculator procedure which uses the PC, BF or ILS methods in Cases A, B and C respectively. The advantage in using this procedure is that the choice of the method to be used and its subsequent application are made automatically by a unique calculator programme.

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Clinical Pharmacy Functions in Ambulatory Patient Care

Hawkins

1981

The Journal of Clinical Pharma

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A functional interpretation of clinical pharmacy as an implementing mechanism for extending the objectives and responsibilities of clinical pharmacology in ambulatory patient care is presented. Evidence is given to support the effectiveness of the clinical pharmacist in assisting primary care physicians with the design of optimal drug regimens and evaluating and managing patients on chronic drug therapy. Opportunities for the clinical pharmacist to carry out long-term drug trials and participate in the design and execution of epidemiological drug studies are also discussed. The clinical pharmacist can make important contributions to ambulatory patient care in areas of drug treatment and evaluation by working in concert with primary care physicians and clinical pharmacologists.

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Rapid Metabolism of Phenytoin A Method of Calculating Proper Dosage

Cited by 3 publications

References 10 publications

Interference in Immunoassays Used for Monitoring Anticonvulsants and the Usefulness of Monitoring Free Anticonvulsants

Interference in Immunoassays Used for Monitoring Anticonvulsants and the Usefulness of Monitoring Free Anticonvulsants

Comparative Analysis of the Pharmacokinetic Techniques Available for Individualizing Phenytoin Dosage

Clinical Pharmacy Functions in Ambulatory Patient Care

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