Rapid-melt Dynamic Nuclear Polarization

Sharma, Manvendra; Janssen, Gerrit; Leggett, James; Kentgens, A.P.M.; Bentum, P.J.M. van

doi:10.1016/j.jmr.2015.06.007

Cited by 32 publications

(24 citation statements)

References 113 publications

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“…The design of a dual‐isocenter magnet allows a rapid sample transfer between two different areas of a magnet, an upper compartment for DNP enhancement and a lower compartment for NMR measurement, within 0.7 s . The implementation of a transfer system using microfluidics realizes DNP hyperpolarization and NMR detection in different regions of a purpose‐built NMR probe . For longer transfer paths, enclosure of the transfer tubing in a magnetic tunnel can prevent increased relaxation at low magnetic field …”

Section: Experimental Methodsmentioning

confidence: 99%

Applications of dissolution dynamic nuclear polarization in chemistry and biochemistry

Zhang

Hilty

2018

Magnetic Reson in Chemistry

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Sensitivity of detection is one of the most limiting aspects when applying NMR spectroscopy to current problems in the molecular sciences. A number of hyperpolarization methods exist for increasing the population difference between nuclear spin Zeeman states and enhance the signal-to-noise ratio by orders of magnitude. Among these methods, dissolution dynamic nuclear polarization (D-DNP) is unique in its capability of providing high spin polarization for many types of molecules in the liquid state. Originally proposed for biomedical applications including in vivo imaging, applications in high resolution NMR spectroscopy are now emerging. These applications are the focus of the present review. Using D-DNP, a small sample aliquot is first hyperpolarized as a frozen solid at low temperature, followed by dissolution into the liquid state. D-DNP extends the capabilities of liquid state NMR spectroscopy towards shorter timescales and enables the study of nonequilibrium processes, such as the kinetics and mechanisms of reactions. It allows the determination of intermolecular interactions, in particular based on spin relaxation parameters. At the same time, a challenge in the application of this hyperpolarization method is that spin polarization is nonrenewable. Substantial effort has been devoted to develop methods for enabling rapid correlation spectroscopy, the measurement of time-dependent signals, and the extension of the observable time window. With these methods, D-DNP has the potential to open new application areas in the chemical and biochemical sciences.

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Section: Experimental Methodsmentioning

confidence: 99%

Applications of dissolution dynamic nuclear polarization in chemistry and biochemistry

Zhang

Hilty

2018

Magnetic Reson in Chemistry

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“…This relaxation is particularly challenging in the context of d-DNP. Indeed, apart from the dual center magnet approach from Kockenberger [59] or the in-situ rapid melt approach from van Bentum [60], the hyperpolarized solution usually needs to be transferred to another magnet during which time it is exposed to very low magnetic fields (mT range). The exact magnetic field pattern experienced by the hyperpolarized fluid in our laboratory was mapped systematically with a triple-axis Hall probe [61].…”

Section: Transferring Hyperpolarized Solutions Through a Magnetic Tunnelmentioning

confidence: 99%

Optimizing dissolution dynamic nuclear polarization

Bornet

2016

Journal of Magnetic Resonance

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“…The sample is transferred by an external actuator from the polarizing field to the dissolution system near the measurement field in the solid state and can be dissolved by a heated liquid and flow into the NMR sample tube. For microfluidics applications, a transfer system using a linear actuator to transfer the sample between a freezing zone where polarization is build up to a rapid melting zone and then on to a NMR detection circuit [60] has been proposed and implemented. For very slowly relaxing samples like some silicon nano-and microparticles, a manual transfer of the cold solid sample out of the magnet to the measurement magnet is also feasible [61].…”

Section: Low-loss Transfer Of Polarized Samplesmentioning

confidence: 99%

Conceptual and instrumental progress in dissolution DNP

Jähnig

Kwiatkowski

Ernst

2016

Journal of Magnetic Resonance

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We discuss conceptual and instrumental progress in dissolution DNP since its introduction in 2003. In our view there are three critical steps in the dissolution DNP process: (i) The achievable polarization level in a sample. (ii) The time required to build up the polarization. (iii) The transfer of the sample to the measurement system with minimum loss of polarization. In this review we describe in detail these steps and the different methodological and instrumental implementations, which have been proposed to optimize them.

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Rapid-melt Dynamic Nuclear Polarization

Cited by 32 publications

References 113 publications

Applications of dissolution dynamic nuclear polarization in chemistry and biochemistry

Applications of dissolution dynamic nuclear polarization in chemistry and biochemistry

Optimizing dissolution dynamic nuclear polarization

Conceptual and instrumental progress in dissolution DNP

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