Conceptual and instrumental progress in dissolution DNP

Jähnig, Fabian; Kwiatkowski, Grzegorz; Ernst, Matthias

doi:10.1016/j.jmr.2015.12.024

Cited by 35 publications

(26 citation statements)

References 66 publications

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“…Rapid sample injection techniques can improve the efficiency of sample transfer to the NMR spectrometer and increase the final polarization level . An automatic device for sample injection was designed by Bowen et al (Figure a,b) .…”

Section: Experimental Methodsmentioning

confidence: 99%

Applications of dissolution dynamic nuclear polarization in chemistry and biochemistry

Zhang

Hilty

2018

Magnetic Reson in Chemistry

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Sensitivity of detection is one of the most limiting aspects when applying NMR spectroscopy to current problems in the molecular sciences. A number of hyperpolarization methods exist for increasing the population difference between nuclear spin Zeeman states and enhance the signal-to-noise ratio by orders of magnitude. Among these methods, dissolution dynamic nuclear polarization (D-DNP) is unique in its capability of providing high spin polarization for many types of molecules in the liquid state. Originally proposed for biomedical applications including in vivo imaging, applications in high resolution NMR spectroscopy are now emerging. These applications are the focus of the present review. Using D-DNP, a small sample aliquot is first hyperpolarized as a frozen solid at low temperature, followed by dissolution into the liquid state. D-DNP extends the capabilities of liquid state NMR spectroscopy towards shorter timescales and enables the study of nonequilibrium processes, such as the kinetics and mechanisms of reactions. It allows the determination of intermolecular interactions, in particular based on spin relaxation parameters. At the same time, a challenge in the application of this hyperpolarization method is that spin polarization is nonrenewable. Substantial effort has been devoted to develop methods for enabling rapid correlation spectroscopy, the measurement of time-dependent signals, and the extension of the observable time window. With these methods, D-DNP has the potential to open new application areas in the chemical and biochemical sciences.

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Section: Experimental Methodsmentioning

confidence: 99%

Applications of dissolution dynamic nuclear polarization in chemistry and biochemistry

Zhang

Hilty

2018

Magnetic Reson in Chemistry

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“…In this publication, we describe the hardware design of a home-built 7 T polarizer suitable for dissolution dynamic nuclear polarization. The design is based on our previous 3.4 T polarizer 30,31 that is in use in our laboratory for basic research 30,32,33 and for in-vivo studies on small animals 34,35 using primarily trityl radicals as electron source.…”

Section: Introductionmentioning

confidence: 99%

Dissolution DNP using trityl radicals at 7 T field

Jähnig

Kwiatkowski

Däpp

et al. 2017

Phys. Chem. Chem. Phys.

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Dissolution DNP has become an important method to generate highly polarized substrates such as pyruvic acid for in vivo imaging and localized spectroscopy. In a quest to further increase the polarization levels, which is important for in vivo MRI employing C detection, we describe the design and implementation of a new DNP polarizer that is suitable for dissolution operation at 7 T static magnetic field and a temperature of 1.4 K. We describe all important sample preparation steps and experimental details necessary to optimize trityl based samples for use in our polarizer at this higher field. In [1-C]-pyruvic acid polarization levels of about 56% are achieved, compared to typical polarization levels of about 35-45% at a standard field of 3.4 T. At the same time, the polarization build-up time increases significantly from about 670 s at 3.4 T to around 1300-1900 s at 7 T, depending on the trityl derivate used. We also investigate the effect of adding trace amounts of Gd to the samples. While one trityl compound does not exhibit any benefit, the other profits significantly, boosting achievable polarization by 6%.

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“…A commercial, fully automated system is available, which is suitably scaled for applications in chemistry and pre‐clinical research, while a more recent system is designed for clinical applications . Many recent hardware developments, however, are only available on custom‐built systems . Figure shows the example of the custom‐built system of Ernst and co‐workers …”

Section: Dissolution Dynamic Nuclear Polarisationmentioning

confidence: 99%

“…Many recent hardware developments, however, are only available on custom‐built systems . Figure shows the example of the custom‐built system of Ernst and co‐workers …”

Section: Dissolution Dynamic Nuclear Polarisationmentioning

confidence: 99%

Perspectives on hyperpolarised solution‐state magnetic resonance in chemistry

Dumez

2016

Magnetic Reson in Chemistry

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This perspective article reviews some of the recent developments in the field of hyperpolarisation, with a focus on solution-state NMR spectroscopy of small molecules. Two techniques are considered in more detail, dissolution dynamic nuclear polarisation (D-DNP) and signal amplification by reversible exchange (SABRE). Some of the opportunities and challenges for applications of hyperpolarised solution-state magnetic resonance in chemistry are discussed. Copyright © 2016 John Wiley & Sons, Ltd.

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Conceptual and instrumental progress in dissolution DNP

Cited by 35 publications

References 66 publications

Applications of dissolution dynamic nuclear polarization in chemistry and biochemistry

Applications of dissolution dynamic nuclear polarization in chemistry and biochemistry

Dissolution DNP using trityl radicals at 7 T field

Perspectives on hyperpolarised solution‐state magnetic resonance in chemistry

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