Rapid isolation of geraniin from Nephelium lappaceum rind waste and its anti-hyperglycemic activity

Palanisamy, Uma Devi; Ling, Lai; Manaharan, Thamilvaani; Appleton, David R.

doi:10.1016/j.foodchem.2010.12.070

Cited by 173 publications

(112 citation statements)

References 35 publications

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“…Geraniin is also an excellent inhibitor of carbohydrate hydrolysing enzymes (α-glucosidase and α-amylase) -superior to the positive control acarbose (carbohydrate hydrolysis inhibitor). It was far more effective in preventing polyol and advanced glycation endproducts formation as compared to the positive controls quercetin and green tea which reveals geraniin as an ideal candidate for the management of hyperglycemia in diabetic individuals [149].…”

Section: The Most Important Catechins Of Green Tea Are (-)-Epicatechimentioning

confidence: 97%

“…It was also identified as the major bioactive compound in an ethanolic Nephelium lappaceum L. rind extract [149]. Previous studies have shown that N. lappaceum rind extract exhibits high anti-oxidant activity [150].…”

Section: The Most Important Catechins Of Green Tea Are (-)-Epicatechimentioning

confidence: 99%

“…Previous studies have shown that N. lappaceum rind extract exhibits high anti-oxidant activity [150]. In 2011 Palanisamy et al reported the ability of geraniin to scavenge free radicals and to possess in vitro hypoglycemic activity [149]. Geraniin is also an excellent inhibitor of carbohydrate hydrolysing enzymes (α-glucosidase and α-amylase) -superior to the positive control acarbose (carbohydrate hydrolysis inhibitor).…”

Section: The Most Important Catechins Of Green Tea Are (-)-Epicatechimentioning

confidence: 99%

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Plant-Derived Agents with Anti-Glycation Activity

Odjakova¹,

Popova²,

Sharif³

et al. 2012

Glycosylation

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Section: The Most Important Catechins Of Green Tea Are (-)-Epicatechimentioning

confidence: 97%

Section: The Most Important Catechins Of Green Tea Are (-)-Epicatechimentioning

confidence: 99%

Section: The Most Important Catechins Of Green Tea Are (-)-Epicatechimentioning

confidence: 99%

See 1 more Smart Citation

Plant-Derived Agents with Anti-Glycation Activity

Odjakova¹,

Popova²,

Sharif³

et al. 2012

Glycosylation

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“…Geraniin (GE) (C 41 H 28 O 27 .7H 2 O) (Figure 1), an ellagitannin, was identified as the major compound in the ethanolic extracts of N. lappaceum L. (Sapindaceae) rind, with yields of almost 30% by weight and a molecular weight of 952 g/mol (Palanisamy et al, 2011b). Corilagin (CO) (C 27 H 24 O 18 ), ellagic acid (EA) (C 14 H 6 O 8 ), and gallic acid (GA) (C 7 H 6 O 5 ) (Figure 1) have been shown to be the main metabolites of GE (Ito et al, 2007;Thitilertdecha et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

“…Corilagin (CO) (C 27 H 24 O 18 ), ellagic acid (EA) (C 14 H 6 O 8 ), and gallic acid (GA) (C 7 H 6 O 5 ) (Figure 1) have been shown to be the main metabolites of GE (Ito et al, 2007;Thitilertdecha et al, 2010). GE and its metabolites have been found to possess a range of bioactive properties, which include antioxidant and free radical scavenging activity (Bala et al, 2006;Palanisamy et al, 2008), anticancer (Yoshida et al, 2005), antimicrobial (Konishi et al, 2004), antiviral (Notka et al, 2003;Yang et al, 2008), and anti-hyperglycemic activity (Palanisamy et al, 2011b). However, the physicochemical properties, permeability, absorption, and metabolism of these compounds are still poorly understood.…”

Section: Introductionmentioning

confidence: 99%

The physicochemical properties of geraniin, a potential antihyperglycemic agent

Elendran

Wang

Prankerd

et al. 2015

Pharmaceutical Biology

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Context: Natural products play a vital role in the discovery of leads for novel pharmacologically active drugs. Geraniin (GE) was identified as the major compound in the rind of Nephelium lappaceum L. (Sapindaceae), while ellagic and gallic acids have been shown to be its main metabolites. GE and its metabolites possess a range of bioactive properties including being an anti-infective, anticarcinogenic, antihyperglycemic, and antihypertensive. Objective: GE and its metabolites were investigated to establish its gastrointestinal absorption and physicochemical properties. Materials and methods: GE was purified from N. lappaceum rind extract using reverse-phase C18 column chromatography. Lipophilicity (log P) was determined using the 1-octanol/water shakeflask method. Equilibrium solubility of GE and its metabolites (20 mg) was determined in water and four biorelevant media: simulated gastric, simulated intestinal, fasted state-simulated intestinal, and fed state-simulated intestinal after 72 h. Results and discussion: The purification yield was 10.8%; where a 97-99% pure GE was obtained. Log P values for GE, ellagic, and gallic acids were established as À0.73 ± 0.17, 0.11 ± 0.06, and 0.71 ± 0.21, respectively, establishing them as polar compounds. All three compounds were found to exhibit poor solubility in gastric (0.61-8.10 mg/mL) but good solubility in intestinal fluids (3.59-14.32 mg/mL). Conclusion:The above results indicate that the compounds have limited gastrointestinal absorption due to its polarities. To consider these compounds as oral drug candidates, formulation strategies are being developed.

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Rambutan ( Nephelium lappaceum L .)

Akhtar

Ismail

Shaari

2017

Fruit and Vegetable Phytochemicals

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Polyphenol oxidase (PPO) from rambutan (Nephelium lappaceum L) peel was extracted and purified by (NH ) SO precipitation, ion-exchange chromatography and gel filtration chromatography. The biochemical 4 2 4characteristics reveal that the PPO from rambutan peel has higher affinity towards catechol (K = 13.7mM and M V = 18,105 U/ml min ) at an optimum pH of 5.9. The enzyme had an optimum temperature of 37°C and was max 1 relatively stable up to 47°C for a period of 60 minutes with almost 77% activity remaining. Among the various PPO inhibitors tested, the most effective inhibitor for the enzyme with 10mM catechol as substrate was ascorbic acid.

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Rapid isolation of geraniin from Nephelium lappaceum rind waste and its anti-hyperglycemic activity

Cited by 173 publications

References 35 publications

Plant-Derived Agents with Anti-Glycation Activity

Plant-Derived Agents with Anti-Glycation Activity

The physicochemical properties of geraniin, a potential antihyperglycemic agent

Rambutan ( Nephelium lappaceum L .)

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