Rapid growth of hydroxyapatite nanoparticles using ultrasonic irradiation

Abstract

A rapid, environmental friendly and low-cost method to prepare hydroxyapatite nanoparticles is proposed. In this method, hydroxyapatite is produced in a sonicated pseudo-body solution. The sonication time was found effective in the formation of the crystalline phase of nanoparticles. In our experimental condition, 15 min sonication resulted in the most pure hydroxyapatite phase. Also it was shown that growth temperature is a crucial factor and hydroxyapatite crystallizes only at 37 degrees C. The particles formed by sonication were generally smaller and more spherical than those obtained without sonication. Sonication increased the hydroxyapatite crystal growth rate up to 5.5 times compared to non-sonication condition. The comparison between the specific surface area of hydroxyapatite nanoparticles obtained by sonication and without sonication demonstrated that sonication increased the specific surface area from 63 m(2)/g to 107 m(2)/g and decreased the size of nanoparticles from 30 nm to 18 nm. Analysis on the pore structure demonstrated that the fractal structures obtained with and without sonication were considerably different.

Nanodimensional and Nanocrystalline Calcium Orthophosphates

“…Continuous preparation procedures are also available [200,458]. Application of both ultrasound [362,[459][460][461] and viscous systems [462] might be helpful. Furthermore, nanodimensional HA might be manufactured by a laser-induced fragmentation of HA targets in water [463][464][465][466][467] and in solvent-containing aqueous solutions [344,371,468], while dense nanocrystalline HA films might be produced by radio frequency magnetron sputtering [469,470].…”

Nanoscale conversion of chlorapatite into hydroxyapatite using ultrasound irradiation

“…However, a decrease of particle dimension is also observed with pure HAp particles prepared using HNO 3 after a similar ultrasound treatment. Several previous reports have demonstrated the ability of ultrasound to tune HAp particle size but these studies were devoted to particle growth from Ca 2+ and phosphate salts [13][14][15][16][17][18][19][20][21] and often describes a continuous process occurring from an amorphous calcium phosphate phase to crystalline HAp. In these works, decrease of particle size upon irradiation was attributed to the formation of hot spots resulting from cavitation bubbles collapse that favor nucleation events.…”

“…Therefore many physical and chemical routes have been developed to obtain phosphocalcic apatites as high surface area powders from inorganic salts [12]. Of particular interest here are sonochemistry routes that allow control of the particle size and crystallinity through the modulation of irradiation power and duration [13][14][15][16][17][18][19][20][21]. As a more sustainable alternative, a process allowing for the conversion of natural phosphate into porous hydroxyapatite (Ca 10 (PO 4 ) 6 (OH) 2 ) was recently described [22,23].…”

Konversi Koral Laut Menjadi Hidroksiapatit Dengan Metode Sonikasi

“…menjadi CHAp dilakukan dengan metode sonikasi seperti yang dikerjakan oleh (Rouhani, Taghavinia, and Rouhani 2010 (Han et al 2007).…”