Rapid growing cystic variant of choroid plexus papilloma in a fetal cerebral hemisphere

Murata, Masaru; Morokuma, Seiichi; Tsukimori, Kiyomi; Hojo, Satoshi; Morioka, Takato; Hashiguchi, Kimiaki; Sasaki, Tatsuya; Wake, Norio

doi:10.1002/uog.6262

Cited by 8 publications

(5 citation statements)

References 34 publications

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“…Minor calcification of the fibrovascular stroma is not an uncommon sign. Expansion of cysts accompanying a CPP may be seen,27 and deterioration of cerebral tissue through cystic development is found sporadically 28. In our case we saw a relatively high mitotic activity, leading to a WHO Grade II classification.…”

Section: Discussionmentioning

confidence: 46%

“…On T2‐weighted imaging, the lesion is hyperintense 1, 32. CT shows an isodense to hyperdense lesion often with intra‐tumoral calcifications and with uniform contrast enhancement 6, 28, 30. On transabdominal fetal ultrasound, CPP is an echogenic, lobulated intraventricular tumor, typically associated with feeding vessel(s) on color flow Doppler mapping.…”

Section: Discussionmentioning

confidence: 99%

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Prenatal diagnosis and successful postnatal therapy of an atypical choroid plexus papilloma—Case report and review of literature

Hartge

Axt-Fliedner

Weichert

2010

J of Clinical Ultrasound

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This report describes the perinatal management of a prenatally detected choroid plexus papilloma in an otherwise unaltered singleton pregnancy of a healthy woman. After elective Caesarean section, a successful embolization of the feeding vessel followed by a craniotomy and complete removal of the remaining tumor were performed. Histological examination confirmed the diagnosis. One-, 2-, and 3-year follow-up showed a normal development of the girl with a regular neuropediatric status. A review of literature including related papers listed in PubMed between 1985 and 2009 are included.

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Section: Discussionmentioning

confidence: 46%

Section: Discussionmentioning

confidence: 99%

Prenatal diagnosis and successful postnatal therapy of an atypical choroid plexus papilloma—Case report and review of literature

Hartge

Axt-Fliedner

Weichert

2010

J of Clinical Ultrasound

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“…Choroid plexus papillomas can present with cysts in 20% of cases [7,11,22]. Similar to the illustrated case, they can appear either as pure cystic tumors or as cystic tumors with solitary or multiple mural nodules [28][29][30][31][32]. Cyst formation was postulated to either be from CSF production of the tumor or hemorrhages in the tumor [7,11] although there was only one radiographically documented case of a choroid plexus papilloma with hemorrhage [10].…”

Section: Discussionmentioning

confidence: 60%

Pediatric choroid plexus papilloma arising from the cerebellopontine angle: systematic review with illustrative case

et al. 2020

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Introduction Choroid plexus tumors are uncommon intraventricular tumors that develop from the choroid plexus of the central nervous system. Choroid plexus papillomas arising from the cerebellopontine angle have been reported to almost exclusively occur in adults and are rarely found in children. Methods We report a systematic review conducted in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines of SCOPUS and PubMed databases for case reports and case series of choroid plexus papillomas arising in the cerebellopontine angle in the pediatric population and discuss clinical presentation, imaging features, management options, and outcomes. We also report a case managed at our center. Results Ten cases of pediatric choroid plexus papillomas arising in the cerebellopontine angle were identified from the systematic review in addition to the case reported here, resulting in a total of eleven cases. The patients' median age was 8 years with a slight female sex predilection (1.2:1). Patients most commonly presented with headache, cerebellar signs, and cranial nerve palsies with median duration of symptoms at 4 months. All patients underwent surgical treatment with majority achieving gross total excision. No deaths were reported at median follow-up of 12 months. Complete neurologic recovery was attained in seven cases while partial recovery was seen in two cases. Conclusion Choroid plexus papillomas found in the cerebellopontine angle in the pediatric population are extremely rare but they should be considered in the differential diagnosis. Complete surgical resection is the mainstay of treatment with excellent outcomes achievable in majority of patients.

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“…Cysts develop within the tumor or adjacent cortex in 7.5% of patients with CPPs. They are found on imaging either before birth, after birth, or following surgical resection [2,19,31,41,52,76]. Cysts range in size and occur on or directly beneath the ependymal lining.…”

Section: Pathologymentioning

confidence: 99%

“…Microscopically, the cysts are lined by cuboidal to columnar choroid plexus-like cells and contain pale yellow fluid. Cysts markedly increase in size in utero [52]. Most occur concomitantly in patients with CPPs, 4/53 or 7.5%.…”

Section: Pathologymentioning

confidence: 99%

Perinatal (fetal and neonatal) choroid plexus tumors: a review

Crawford

Isaacs

2019

Childs Nerv Syst

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Introduction The object of this review is to describe the choroid plexus tumors (CPTs) occurring in the fetus and neonate with regard to clinical presentation, location, pathology, treatment, and outcome. Materials and methods Case histories and clinical outcomes were reviewed from 93 cases of fetal and neonatal tumors obtained from the literature and our own institutional experience from 1980 to 2016. Results Choroid plexus papilloma (CPP) is the most common tumor followed by choroid plexus carcinoma (CPC) and atypical choroid plexus papilloma (ACPP). Hydrocephalus and macrocephaly are the presenting features for all three tumors. The lateral ventricles are the main site of tumor origin followed by the third and fourth ventricles, respectively. CPTs of the fetus are detected most often near the end of the third trimester of pregnancy by fetal ultrasound. The extent of surgical resection plays an important role in the treatment and outcome. In spite of excellent survival, which is especially true in the case of CPP, surgical resection may carry significant risks in an immature baby. Given the neonatal low blood volume and increased vascularity of the tumors, there is potential risk for hemorrhage. Although advances in neurosurgical techniques have led to a greater degree of complete surgical resections, survival for the perinatal CPC group remains low even with multimodality therapies. Conclusion Perinatal CPTs have variable overall survivals depending on degree of surgical resection and tumor biology. An increased understanding of the molecular features of these tumors may lead to improved therapies and ultimately survival. Keywords Fetal choroid plexus papilloma. Neonatal choroid plexus papilloma. Fetal choroid plexus carcinoma. Neonatal choroid plexus carcinoma. Fetal atypical choroid plexus papilloma. Neonatal atypical choroid plexus papilloma. Congenital brain tumor. Intracranial hemorrhage

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Rapid growing cystic variant of choroid plexus papilloma in a fetal cerebral hemisphere

Cited by 8 publications

References 34 publications

Prenatal diagnosis and successful postnatal therapy of an atypical choroid plexus papilloma—Case report and review of literature

Prenatal diagnosis and successful postnatal therapy of an atypical choroid plexus papilloma—Case report and review of literature

Pediatric choroid plexus papilloma arising from the cerebellopontine angle: systematic review with illustrative case

Perinatal (fetal and neonatal) choroid plexus tumors: a review

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