Prenatal diagnosis and successful postnatal therapy of an atypical choroid plexus papilloma—Case report and review of literature

Abstract

This report describes the perinatal management of a prenatally detected choroid plexus papilloma in an otherwise unaltered singleton pregnancy of a healthy woman. After elective Caesarean section, a successful embolization of the feeding vessel followed by a craniotomy and complete removal of the remaining tumor were performed. Histological examination confirmed the diagnosis. One-, 2-, and 3-year follow-up showed a normal development of the girl with a regular neuropediatric status. A review of literature including related papers listed in PubMed between 1985 and 2009 are included.

Feasibility and value of preoperative embolization of a congenital choroid plexus tumour in the premature infant: An illustrative case report with technical details

“…2 There are few reports in the literature about surgical management of choroid plexus tumour in the preterm infant. [3][4][5] However, only one of them utilized preoperative embolization in a premature baby. 5 Our case provides further insight in the technical aspect of embolization in the premature baby.…”

Perinatal (fetal and neonatal) choroid plexus tumors: a review

“…1a). In the pediatric age group, half occur in the first year of life [4,12,30,41,66,[76][77][78]. Hydrocephalus, macrocephaly, and a mass on imaging are the major presenting findings.…”

“…ACPP is neoplasm of neuroepithelial origin consisting of epithelial cells that are thought to be derived from the ventricular choroid plexuses. This tumor is responsible also for the rapid onset of perinatal hydrocephalus and occasionally stillbirth [20,30,49,53,68]. Nine patients, consisting of five fetuses and four neonates with this diagnosis, were identified in the literature (Table 1).…”

“…In common with CPP and CPC hydrocephalus, an intracranial mass and macrocephaly are the presenting findings. Fetuses with ACPP are found most often by prenatal imaging [20,25,30,64]. The tumor has greater recurrence and mortality rates than CPP but lesser ones than those of CPC.…”

“…As mentioned above, there are recent reports stating that increased mitotic activity is prognostic only in older children [37,70]. Treatment and outcome Surgical resection, embolization, and chemotherapy are the main forms of treatment [20,30,80]. Locating and cannulating tiny choroidal tumor feeding vessels, especially those of low birth weight premature infants, can be a difficult technical problem when performing a surgical resection or embolization.…”