Rapid genotype analysis of the matrix metalloproteinase-1 gene 1G/2G polymorphism that is associated with risk of cancer

Dunleavey, L; Beyzade, Seyyare; Ye, Shu

doi:10.1016/s0945-053x(00)00059-7

Cited by 40 publications

(28 citation statements)

References 5 publications

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“…Gene polymorphisms were analyzed using the polymerase chain reaction (PCR) followed by the restriction fragment length polymorphism (RFLP) method according to previous reports (8,(29)(30)(31)(32)(33) (Table 1). 44).…”

Section: Genotype Analysismentioning

confidence: 99%

The Genotypes of IL-1 beta and MMP-3 are Associated with the Prognosis of HCV-related Hepatocellular Carcinoma

et al. 2010

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Background and Aim Cytokines and matrix metalloproteinases (MMPs) beta (IL-1b), IL-1 receptor antagonist (IL-1 RN), transforming growth factor beta 1 (TGF-b1), MMP-1, MMP-3, and MMP-9 and the prognosis of hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC). Methods We enrolled 92 HCV-related HCC patients in the study, and gene polymorphisms of IL-1b -31 C/ T, IL-1 RN variable number of tandem repeats (VNTR), TGF-b1 +869 C/T, MMP-1 -1,607 1G/2G, MMP-3 -1,171 5A/6A, and MMP-9 -1,562 C/T were analyzed. Results In HCC clinical features, TGF-b1 C carriers and MMP-3 5A carriers had significantly larger HCC diameters than TGF-b1 T and MMP-3 6A homozygotes. In HCC prognosis, IL-1b T homozygotes and

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Section: Genotype Analysismentioning

confidence: 99%

The Genotypes of IL-1 beta and MMP-3 are Associated with the Prognosis of HCV-related Hepatocellular Carcinoma

et al. 2010

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“…28 The methods used to type the MMP-1 1G/2G, MMP-3 5A/6A, MMP-9 C-1562T, and MMP-12 A-82G polymorphisms have been described previously. 17,21,29,30 Briefly, the DNA sequence containing the relevant polymorphic site was amplified by polymerase chain reaction (PCR), and the amplicon was digested with an appropriate restriction enzyme that cleaves only 1 of the 2 alleles. The digests were then subjected to gel electrophoresis and visualized by Vistra green or ethidium bromide staining.…”

Section: Determination Of Genotypesmentioning

confidence: 99%

Polymorphisms in Matrix Metalloproteinase-1, -3, -9, and -12 Genes in Relation to Subarachnoid Hemorrhage

Zhang

Dhillon

Geary

et al. 2001

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Background and Purpose-Intracranial aneurysm, which underlies the vast majority of subarachnoid hemorrhage incidences, has a multifactorial etiology, and the importance of genetic factors is increasingly recognized. Development and rupture of intracranial aneurysms involve degradation and remodeling of the vascular wall matrix in which the matrix metalloproteinases (MMPs) play an important role. The possible impact of MMP gene polymorphisms on susceptibility to intracranial aneurysms is still controversial, with conflicting data from different reported studies. Methods-In this study we analyzed 5 different functional promoter polymorphisms in the MMP-1, MMP-3, MMP-9, and MMP-12 genes in a sample of 92 patients with aneurysmal subarachnoid hemorrhage and 158 healthy control subjects, all from southern England. Results-No significant difference was detected between the patient and control groups in genotype distribution of any of the polymorphisms studied. Conclusions-The

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“…The solution was incubated at 37 8C overnight. Two mismatches were introduced in the reverse primer that annealed in the proximity of the polymorphism, 42 which created a recognition sequence (5 0 -GAANNNNTTC-3 0 ) for the restriction endonuclease XmnI (Invitrogen, San Diego, CA, USA) when the DNA template contains 1G (but not 2G) at the polymorphism site. Thus, XmnI digests the 1G allele, creating two fragments of 89 bp and 29 bp.…”

Section: Analysis Of Mmp1-1607 (1g/2g) Polymorphism By Polymerase Chamentioning

confidence: 99%

Analysis of the association of an MMP1 promoter polymorphism and transcript levels with chronic periodontitis and end-stage renal disease in a Brazilian population

Luczyszyn

Souza

Braosi

et al. 2012

Archives of Oral Biology

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Rapid genotype analysis of the matrix metalloproteinase-1 gene 1G/2G polymorphism that is associated with risk of cancer

Cited by 40 publications

References 5 publications

The Genotypes of IL-1 beta and MMP-3 are Associated with the Prognosis of HCV-related Hepatocellular Carcinoma

The Genotypes of IL-1 beta and MMP-3 are Associated with the Prognosis of HCV-related Hepatocellular Carcinoma

Polymorphisms in Matrix Metalloproteinase-1, -3, -9, and -12 Genes in Relation to Subarachnoid Hemorrhage

Analysis of the association of an MMP1 promoter polymorphism and transcript levels with chronic periodontitis and end-stage renal disease in a Brazilian population

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