Rapid Formation of Stem Cell Spheroids Using Two-Dimensional MXene Particles

Jang, JunHwee; Lee, Eunjung

doi:10.3390/pr9060957

Cited by 22 publications

(3 citation statements)

References 24 publications

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“…It was found that the spheroids could promote the osteogenic differentiation of hMSCs, and showed significant ALP activity and active mineralization without osteogenic medium. 95 Zhang et al…”

Section: Mxene Nanomaterials For Bone Tissue Engineering and Regenera...mentioning

confidence: 99%

“…Jang et al ingeniously used MXene nanoparticles as cell adhesive to quickly form hMSC spheroids. It was found that the spheroids could promote the osteogenic differentiation of hMSCs, and showed significant ALP activity and active mineralization without osteogenic medium 95 . Zhang et al reported that a multilayer MXene film improved the adhesion, proliferation and osteogenic differentiation of mouse preosteoblasts (MC3T3‐E1) in vitro 96 .…”

Section: Applications Of Mxene Nanomaterials In Tissue Engineering An...mentioning

confidence: 99%

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Recent advances and trends in the applications of MXene nanomaterials for tissue engineering and regeneration

Zhong

Huang

Feng

et al. 2022

J Biomedical Materials Res

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MXene, as a new two‐dimensional nanomaterial, is endowed with lots of particular properties, such as large surface area, excellent conductivity, biocompatibility, biodegradability, hydrophilicity, antibacterial activity, and so on. In the past few years, MXene nanomaterials have become a rising star in biomedical fields including biological imaging, tumor diagnosis, biosensor, and tissue engineering. In this review, we sum up the recent applications of MXene nanomaterials in the field of tissue engineering and regeneration. First, we briefly introduced the synthesis and surface modification engineering of MXene. Then we focused on the application and development of MXene and MXene‐based composites in skin, bone, nerve and heart tissue engineering. Uniquely, we also paid attention to some research on MXene with few achievements at present but might become a new trend in tissue engineering and regeneration in the future. Finally, this paper will also discuss several challenges faced by MXene nanomaterials in the clinical application of tissue engineering.

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Section: Mxene Nanomaterials For Bone Tissue Engineering and Regenera...mentioning

confidence: 99%

Section: Applications Of Mxene Nanomaterials In Tissue Engineering An...mentioning

confidence: 99%

Recent advances and trends in the applications of MXene nanomaterials for tissue engineering and regeneration

Zhong

Huang

Feng

et al. 2022

J Biomedical Materials Res

View full text Add to dashboard Cite

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“…Recently, MXenes were found to enhance the production of cell spheroids. Lee et al [ 185 ] reported enhanced production of mesenchymal stem cell spheroids using Ti 3 C 2 T x MXene particles as a cell-adhesion agent ( Figure 11 E–G). The spheroid formation was induced within 6 h when a MXene concentration greater than 1 μg/mL was used, and the highest production rate was observed at the MXene concentration of 5 μg/mL.…”

Section: Tissue Engineeringmentioning

confidence: 99%

Advances of MXenes; Perspectives on Biomedical Research

2022

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The last decade witnessed the emergence of a new family of 2D transition metal carbides and nitrides named MXenes, which quickly gained momentum due to their exceptional electrical, mechanical, optical, and tunable functionalities. These outstanding properties also rendered them attractive materials for biomedical and biosensing applications, including drug delivery systems, antimicrobial applications, tissue engineering, sensor probes, auxiliary agents for photothermal therapy and hyperthermia applications, etc. The hydrophilic nature of MXenes with rich surface functional groups is advantageous for biomedical applications over hydrophobic nanoparticles that may require complicated surface modifications. As an emerging 2D material with numerous phases and endless possible combinations with other 2D materials, 1D materials, nanoparticles, macromolecules, polymers, etc., MXenes opened a vast terra incognita for diverse biomedical applications. Recently, MXene research picked up the pace and resulted in a flood of literature reports with significant advancements in the biomedical field. In this context, this review will discuss the recent advancements, design principles, and working mechanisms of some interesting MXene-based biomedical applications. It also includes major progress, as well as key challenges of various types of MXenes and functional MXenes in conjugation with drug molecules, metallic nanoparticles, polymeric substrates, and other macromolecules. Finally, the future possibilities and challenges of this magnificent material are discussed in detail.

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