Rapid formation of nanocrystalline apatite

Sarig, S.; Kahana, F.

doi:10.1016/s0022-0248(01)01850-4

Cited by 99 publications

(62 citation statements)

References 4 publications

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“…Yeong and Wang [72] used CaHPO 4 and CaO as raw materials and fabricated well-crystallized HAp nanoparticles (particle size 25 nm, [26,[125][126][127] specific surface area 75 m 2 g −1 ) after 20 h of mechanical activation. They proposed a mechanism for the dry mechanochemical reaction: the initial stage of the mechanical activation resulted in a refinement in apatitic crystallite and particle sizes after amorphization (fragmentation and fracture) of the starting CaHPO 4 and CaO.…”

Section: Dry Synthesismentioning

confidence: 99%

“…Microwave irradiation [124][125][126][127] can be used instead of conventional heating in pressure-resistant vessels. The hydrothermal process usually produces HAp particles with larger size (up to millimeter range), higher degree of crystallinity and a Ca/P ratio close to the stoichiometric value compared with those obtained by the precipitation processes at lower temperature (see section 2.2.1).…”

Section: Hydrothermal Processmentioning

confidence: 99%

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Hydroxylapatite nanoparticles: fabrication methods and medical applications

Okada

Furuzono

2012

Science and Technology of Advanced Materials

126

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Hydroxylapatite (or hydroxyapatite, HAp) exhibits excellent biocompatibility with various kinds of cells and tissues, making it an ideal candidate for tissue engineering, orthopedic and dental applications. Nanosized materials offer improved performances compared with conventional materials due to their large surface-to-volume ratios. This review summarizes existing knowledge and recent progress in fabrication methods of nanosized (or nanostructured) HAp particles, as well as their recent applications in medical and dental fields. In section 1, we provide a brief overview of HAp and nanoparticles. In section 2, fabrication methods of HAp nanoparticles are described based on the particle formation mechanisms. Recent applications of HAp nanoparticles are summarized in section 3. The future perspectives in this active research area are given in section 4.

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Section: Dry Synthesismentioning

confidence: 99%

Section: Hydrothermal Processmentioning

confidence: 99%

Hydroxylapatite nanoparticles: fabrication methods and medical applications

Okada

Furuzono

2012

Science and Technology of Advanced Materials

126

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“…[473] 2002 Direct precipitation from dilute calcium chloride and sodium orthophosphate solutions. [474] 2003 Radio frequency plasma spray process employing fine spray dried HA powders (average size ~ 15 μm) as a feedstock. [393] 2003 Sol-gel process using equimolar solutions of calcium nitrate and diammonium hydrogen orthophosphate dissolved in ethanol.…”

Section: Yearmentioning

confidence: 99%

“…Nanocrystalline plate-shaped particles of HA were directly precipitated at ambient temperature and pH ~ 7.4 from dilute aqueous solutions of calcium chloride and sodium orthophosphate. The direct precipitation of nano-sized HA was achieved by submitting the aqueous suspension to microwave irradiation immediately after mixing [474]. A simple and easy approach for synthesizing thermally stable nanostructured stoichiometric HA powder under invariant pH conditions of 7.5, known as the NanoCaP process, was developed.…”

Section: Yearmentioning

confidence: 99%

Nanodimensional and Nanocrystalline Calcium Orthophosphates

Dorozhkin¹

2012

AJBE

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Nano-sized particles and crystals play an important role in the formation of calcified tissues of various animals. For example, nano-sized and nanocrystalline calcium orthophosphates in the form of apatites of biological origin represent the basic inorganic building blocks of bones and teeth of mammals. Namely, according the recent developments in biomineralization, tens to hundreds nanodimensional crystals of a biological apatite are self-assembled into these complex structures. This process occurs under a strict control by bioorganic matrixes. Furthermore, both a greater viability and a better proliferation of various types of cells have been detected on smaller crystals of calcium orthophosphates. Thus, the nano-sized and nanocrystalline forms of calcium orthophosphates have a great potential to revolutionize the hard tissue-engineering field, starting from bone repair and augmentation to controlled drug delivery systems. This review reports on current state of the art and recent developments on the subject, starting from synthesis and characterization to biomedical and clinical applications. Furthermore, the review also discusses possible directions for future research and development.

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“…Therefore, different production methods were reported such as mechanochemistry [3,4], ultrasonic irradiation [5], microwave irradiation [6,7], sol-gel [8][9][10][11], chemical precipitation [12,13], hydrothermal method [14][15][16], hydrolysis [17], microemulsion [18][19][20], and emulsion liquid membrane [21]. The synthesized HAp does not have adequate biological properties as the natural apatite existing in bones.…”

Section: Introductionmentioning

confidence: 99%