Physiochemical characterizations of hydroxyapatite extracted from bovine bones by three different methods: Extraction of biologically desirable HAp

Barakat, Nasser A.M.; Khalil, Khaled; Sheikh, Faheem A.; Omran, A. M.; Gaihre, Babita; Khil, Soeb M.; Kim, Hee Young

doi:10.1016/j.msec.2008.03.003

Cited by 168 publications

(123 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Deproteinization is an indispensable process to eliminate antigenicity in xenograft bones. Valid strategies to eliminate the antigenicity of xenograft bones are of vital importance in the development of xenogenic bone graft substitutes [36]. It has been shown that deproteinized bones not only lose their immune reactivity, but also retain their osteoinduction and osteoconduction activities [23]..Sintering temperature is seen as an important factor that can alter the characteristics of HA [37].…”

Section: Discussionmentioning

confidence: 99%

Comparison of Two Xenograft Materials Used in Sinus Lift Procedures: Material Characterization and <em>in Vivo</em> Behavior

Fernández¹,

Mazón²,

Gehrke³

et al. 2017

Preprint

View full text Add to dashboard Cite

Abstract:Detailed information about graft material characteristic is crucial to evaluate their clinical outcomes. The present study evaluates the physico-chemical characteristics of two xenografts manufactured on an industrial scale deproteinized at different temperatures (non sintered and sintered) in accordance with a protocol previously used in sinus lift procedures. It compares how the physico-chemical properties influence the material's performance in vivo by a histomorphometric study in retrieved bone biopsies following maxillary sinus augmentation in 10 clinical cases. An X-ray diffraction analysis revealed the typical structure of hydroxyapatite (HA) for both materials. Both xenografts were porous and exhibited intraparticle pores. Strong differences were observed in terms of porosity, crystallinity, and calcium/phosphate. Histomorphometric measurements on the bone biopsies showed statistically significant differences. The physic-chemical assessment of both xenografts, made in accordance with the protocol developed on an industrial scale, confirmed that these products present excellent biocompatibilitity, with similar characteristics to natural bone. The sintered HA xenografts exhibited greater osteoconductivity, but were not completely resorbable (30.80±0.88% residual material). The non sintered HA xenografts induced about 25.92±1.61% of new bone and a high level of degradation after 6 months of implantation. Differences in the physico-chemical characteristics found between the two HA xenografts determined a different behavior for this material.

show abstract

Section: Discussionmentioning

confidence: 99%

Comparison of Two Xenograft Materials Used in Sinus Lift Procedures: Material Characterization and <em>in Vivo</em> Behavior

Fernández¹,

Mazón²,

Gehrke³

et al. 2017

Preprint

View full text Add to dashboard Cite

show abstract

“…Gelatin can be obtained by thermal denaturation and chemical degradation of collagen [127], and is known to benefit cell viability [128]. In the meantime, HA has a chemical composition similar to human mineral tissue and can be synthesized from many natural sources with calcium-based structures, such as bovine bone, mollusk shell and coral [129][130][131]. In combination, these three biomaterials offer potential synergies between physical properties and bioactivity for use as bone substitutes in bone grafts, benefiting a range of surgical applications.…”

Section: Chitosan/gelatin/hydroxyapatite Scaffolds As Potential Biomamentioning

confidence: 99%

Temporomandibular Disorders and BIO-IPNs: in vitro approach to find molecular solution to biological problem

Perchyonok¹,

Grobler²,

Basson³

et al. 2016

Nanomaterials and Regenerative Medicine

View full text Add to dashboard Cite

“…This discrepancy may affect the material's performance [20]. Many reviews have discussed a number of biomaterials and their manufacturing processes for biodegradable scaffold fabrication, but very little work has been done to obtain biomaterials with patient-specific degradation rates [21][22][23][24]. One of the future challenges in bone tissue engineering is to design and manufacture biodegradable scaffolds with a homogeneous growth rate over their entire volume using pore size gradients or specific distributions.…”

Section: Introductionmentioning

confidence: 99%

SEM-EDX Study of the Degradation Process of Two Xenograft Materials Used in Sinus Lift Procedures

Fernández¹,

Gehrke²,

Martı́nez³

et al. 2017

Preprint

View full text Add to dashboard Cite

Some studies have demonstrated that in vivo degradation processes are influenced by the material's physico-chemical properties. The present study compares two hydroxyapatites manufactured on an industrial scale, deproteinized at low and high temperatures, and how physicochemical properties can influence the mineral degradation process of material performance in bone biopsies retrieved 6 months after maxillary sinus augmentation. Residual biomaterial particles were examined by field scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDX) to determine the composition and degree of degradation of the bone graft substitute material. According to the EDX analysis, the Ca/P ratio significantly lowered in the residual biomaterial (1.08±0.32) compared to the initial composition (2.22±0.08) for the low-temperature sintered group, which also presented high porosity, low crystallinity, low density, a large surface area, and poor stability and a high resorption rate compared to the high-temperature sintered material. This demonstrates that variations in the physico-chemical properties of bone substitute material clearly influence the degradation process. Further studies are needed to determine whether the resorption of deproteinized bone particles proceeds slowly enough to allow sufficient time for bone maturation to occur.

show abstract

Physiochemical characterizations of hydroxyapatite extracted from bovine bones by three different methods: Extraction of biologically desirable HAp

Cited by 168 publications

References 40 publications

Comparison of Two Xenograft Materials Used in Sinus Lift Procedures: Material Characterization and <em>in Vivo</em> Behavior

Comparison of Two Xenograft Materials Used in Sinus Lift Procedures: Material Characterization and <em>in Vivo</em> Behavior

Temporomandibular Disorders and BIO-IPNs: in vitro approach to find molecular solution to biological problem

SEM-EDX Study of the Degradation Process of Two Xenograft Materials Used in Sinus Lift Procedures

Contact Info

Product

Resources

About