SEM-EDX Study of the Degradation Process of Two Xenograft Materials Used in Sinus Lift Procedures

Fernández, María Piedad Ramírez; Gehrke, Sérgio Alexandre; Martı́nez, Carlos Pérez; Calvo-Guirado, José Luís; Aza, Piedad N. De

doi:10.20944/preprints201703.0212.v1

Cited by 14 publications

(6 citation statements)

References 56 publications

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“…Cerabone has also assumed to exhibit a very close similarity to human bone due to its porosity and chemical composition. 27 In the purification process of cerabone, the bone tissue is treated at high temperature (>1200°C) to remove all organic compounds and also to kill prions, bacteria and viruses. 8 Despite the high temperature treatment, the porosity and surface structure of the bone matrix should be preserved.…”

Section: Preparation Processes Of Xenogeneic Bone Substitute Materialmentioning

confidence: 99%

Purification processes of xenogeneic bone substitutes and their impact on tissue reactions and regeneration

et al. 2018

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Xenogeneic bone substitute materials are widely used in oral implantology. Prior to their clinical use, purification of the former bone tissue has to be conducted to ensure the removal of immunogenic components and pathogens. Different physicochemical methods are applied for purification of the donor tissue, and temperature treatment is one of these methods. Differences in these methods and especially the application of different temperatures for purification may lead to different material characteristics, which may influence the tissue reactions to these materials and the related (bone) healing process. However, little is known about the different material characteristics and their influences on the healing process. Thus, the aim of this mini-review is to summarize the preparation processes and the related material characteristics, safety aspects, tissue reactions, resorbability and preclinical and clinical data of two widely used xenogeneic bone substitutes that mainly differ in the temperature treatment: sintered (cerabone) and non-sintered (Bio-Oss) bovine-bone materials. Based on the summarized data from the literature, a connection between the material-induced tissue reactions and the consequences for the healing processes are presented with the aim of translation into their clinical application.

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Section: Preparation Processes Of Xenogeneic Bone Substitute Materialmentioning

confidence: 99%

Purification processes of xenogeneic bone substitutes and their impact on tissue reactions and regeneration

et al. 2018

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“…Because OBBM contained organic compounds which were an important accelerating factor for graft degradation. Organic compounds can be dissolved by enzymatic digestion 28 and phagocytotic processes. 37 The degradation rate of organic-containing xenograft was faster than that of ABBM, indicating that positive correlation between organic compounds and degradation rate, similar fact also found in Rfe’s research.…”

Section: Discussionmentioning

confidence: 99%

“…27 Crystallinity and organic compounds play significant roles on the graft degradation. 28,29 Degradation rate of bone grafts decreases along with the increasing crystallinity and crystallinity is highly dependent on sintering temperature. 28 The higher the sintering temperature, the higher crystallinity and the slower degradation rate.…”

Section: Introductionmentioning

confidence: 99%

“…28,29 Degradation rate of bone grafts decreases along with the increasing crystallinity and crystallinity is highly dependent on sintering temperature. 28 The higher the sintering temperature, the higher crystallinity and the slower degradation rate. Organic-containing bone grafts are absorbed mostly by enzymatic digestion and TRAP-positive osteoclastic cell function, which are absorbed faster than collagen-free bone graft without enzymatic digestion.…”

Section: Introductionmentioning

confidence: 99%

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Physiochemical characterization and biological effect of anorganic bovine bone matrix and organic-containing bovine bone matrix in comparison with Bio-Oss in rabbits

Fan

Lü

et al. 2018

J Biomater Appl

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Bovine origin matrix has been widely used in clinical applications and investigated by various research institutions. However, the potential factors that influence bone regeneration are still not thoroughly understood and need further investigations. In this study, bone regeneration properties of anorganic bovine bone matrix (ABBM), organic-containing bovine bone matrix (OBBM), and widely acknowledged anorganic bovine bone matrix (Bio-Oss) were compared. Besides, the correlations between physiochemical characterizations and bone regeneration properties of the three xenografts were also investigated. Physiochemical characterizations were measured by special instrumentations. In animal studies, the three xenografts were implanted into 8-mm-diameter cranial defects of 16 New Zealand white rabbits. The biological effects were evaluated by micro-computed tomography and histomorphometric analysis after 6 and 12 weeks of implantation. The physical characterizations showed that anorganic bovine bone matrix and Bio-Oss had more nanostructures, larger surface area, bigger pore volume, and bigger pore size than that of organic-containing bovine bone matrix. The chemical characterizations showed that anorganic bovine bone matrix and Bio-Oss had higher crystallinity than that of organic-containing bovine bone matrix, and organic-containing bovine bone matrix contained organic nitrogen (N) component. In vivo, anorganic bovine bone matrix and Bio-Oss possessed better bone regeneration properties than that of organic-containing bovine bone matrix. Taken together, nanostructures, larger surface area, bigger pore volume, and bigger pore size of xenografts played an active role in new bone formation. Besides, lower crystallinity and organic N element of xenografts produced a positive effect on graft degradation. The abovementioned findings could provide theoretical basis for better choice in clinical applications and better manufacturing hydroxyapatitederived bone graft in the future.

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“…The sections were observed under transmitted light using a research microscope (Olympus BX53) at low and high magnifications. [ 11 ]…”

Section: Methodsmentioning

confidence: 99%

Histological evaluation of two different anorganic bovine bone matrixes in lateral wall sinus elevation procedure: A retrospective study

Mahesh¹,

Mascarenhas

Bhasin

et al. 2020

Natl J Maxillofac Surg

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Introduction: Grafting in oral implantology involves bone augmentation procedures with various bone graft materials. Success of such procedures is evaluated through the amount of bone volume and bone formed at the grafted site. The primary aim of this prospective study was to histomorphometrically evaluate and compare the new bone formation with Bio Oss or Cerabone in the lateral approach sinus augmentation procedure. Materials and Methods: The research targeted 22 patients who were either partially or completely edentulous posterior maxilla with residual alveolar height 3 mm at the site of implantation and underwent a two staged surgical protocol, with a lateral approach sinus grafting with either Bio Oss or Cerabone. Bone trephine biopsies for histological analysis were harvested 6 months after augmentation while preparing the osteotomies for implant placement trephine. The histologic evaluation was performed comparing the newly formed bone, marrow spaces, biomaterial particles remnants, and presence of osteocytes embedded in both trabecular bone and bone tissue near the anorganic bovine bone. Results: The present study showed that neither of the graft material showed any active osteoclasts and host inflammatory reaction. From sites grafted with Cerabone, an ample amount of mature lamellated bone formation was seen, also host inflammatory response was indicative of minimal reactive inflammatory response suggestive of good acceptability of the graft material by the host. No significant differences between the groups could be detected with regard to new bone formation and residual bone substitute. Conclusion: The results of the study illustrates that both the bone substitute materials allow predictable new bone formation in sinus augmentation procedures.

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SEM-EDX Study of the Degradation Process of Two Xenograft Materials Used in Sinus Lift Procedures

Cited by 14 publications

References 56 publications

Purification processes of xenogeneic bone substitutes and their impact on tissue reactions and regeneration

Purification processes of xenogeneic bone substitutes and their impact on tissue reactions and regeneration

Physiochemical characterization and biological effect of anorganic bovine bone matrix and organic-containing bovine bone matrix in comparison with Bio-Oss in rabbits

Histological evaluation of two different anorganic bovine bone matrixes in lateral wall sinus elevation procedure: A retrospective study

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