Rapid eye movement sleep promotes cortical plasticity in the developing brain

Bridi, Morgan S.; Aton, Sara J.; Seibt, Julie; Renouard, Leslie; Coleman, Tammi; Frank, Marcos G.

doi:10.1126/sciadv.1500105

Cited by 127 publications

(72 citation statements)

References 28 publications

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“…One of the most widely supported ideas in sleep science is that REM sleep functions to facilitate the formation and consolidation of certain types of memory [10,70–72], although this notion is not universally upheld [21,42,73,74]. Numerous studies in rodents and humans have shown, for example, that REM sleep deprivation impairs formation (or expression) of spatial and emotional memories.…”

Section: Rem Sleep Functionmentioning

confidence: 99%

“…Several additional functions have also been ascribed to REM sleep, ranging from facilitating cortical plasticity [10,78] to restoration of aminergic cell/receptor function [79] and heightening general creativity [80,81]. It is worth noting that all of these proposals assume that REM sleep functions to restore some deficit incurred during prior wakefulness.…”

Section: Rem Sleep Functionmentioning

confidence: 99%

“…In healthy humans, REM sleep alternates with, is preceded by, and occupies a significantly smaller fraction of our nightly sleep time than non-REM sleep (also termed slow-wave sleep) [6]. While long viewed as an enigmatic behavioural state, work over the past several decades has begun to inform our understanding of the biological functions of REM sleep [10,11] and has provided us with considerable insights into the anatomic, circuit and synaptic bases by which it is regulated [12–16]. For example, we now know that hippocampal neural activity during REM sleep is critically involved in memory consolidation [17], and that a distributed network of brain circuits and a myriad of neuromodulators regulates REM sleep timing, duration and its hallmark features [12,13,18–20].…”

Section: Introductionmentioning

confidence: 99%

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Neuroscience: A Distributed Neural Network Controls REM Sleep

Peever

Fuller

2016

Current Biology

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Considerable advances in our understanding of the mechanisms and functions of rapid-eye-movement (REM) sleep have occurred over the past decade. Much of this progress can be attributed to the development of new neuroscience tools that have enabled high-precision interrogation of brain circuitry linked with REM sleep control, in turn revealing how REM sleep mechanisms themselves impact processes such as sensorimotor function. This review is intended to update the general scientific community about the recent mechanistic, functional and conceptual developments in our current understanding of REM sleep biology and pathobiology. Specifically, this review outlines the historical origins of the discovery of REM sleep, the diversity of REM sleep expression across and within species, the potential functions of REM sleep (e.g., memory consolidation), the neural circuits that control REM sleep, and how dysfunction of REM sleep mechanisms underlie debilitating sleep disorders such as REM sleep behaviour disorder and narcolepsy.

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Section: Rem Sleep Functionmentioning

confidence: 99%

Section: Rem Sleep Functionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Neuroscience: A Distributed Neural Network Controls REM Sleep

Peever

Fuller

2016

Current Biology

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“…MD led to a shift in ocular dominance due to a small decline in the visual cortical responses to the deprived eye, and an increase in the response to the non-deprived eye [36,37]. Notably, this shift was promoted by post-MD sleep, probably both NREM sleep [36] and REM sleep [38], but not by sleep deprivation. Two underlying mechanisms have been proposed.…”

Section: Introductionmentioning

confidence: 99%

Sleep, synaptic homeostasis and neuronal firing rates

Cirelli

2017

Current Opinion in Neurobiology

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The synaptic homeostasis hypothesis (SHY) states that wake brings about a net overall increase in synaptic strength in many brain circuits that needs to be renormalized by sleep. I will review recent studies that were either specifically designed to test SHY or were interpreted accordingly, including several experiments that focused on changes in neuronal firing rates. I will emphasize that central to SHY is the idea that what is being regulated across the sleep/wake cycle is synaptic strength, not firing rate, and firing rate taken in isolation is not necessarily an adequate proxy for synaptic strength.

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“…The first few hours of sleep are also characterized by the activation of protein kinases and the synthesis of proteins known to mediate LTP. 89, 90, 92 …”

Section: Proposed Sleep Functionsmentioning

confidence: 99%

Sleep function: Toward elucidating an enigma

Krueger

Frank

Wisor

et al. 2016

Sleep Medicine Reviews

Self Cite

307

186

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Summary Sleep function remains controversial. Individual perspectives frame the issue of sleep function differently. We briefly illustrate how sleep measurement and the evolution, tissue organization levels, molecular mechanisms, and regulation of sleep could influence one’s view of sleep function. Then we discuss six viable theories of sleep function. Sleep serves host-defense mechanisms and conserves caloric expenditures, but these functions likely are opportunistic functions evolving later in evolution. That sleep replenishes brain energy stores and that sleep serves a glymphatic function by removing toxic byproducts of waking activity are attractive ideas, but lack extensive supporting experimental evidence. That sleep restores performance is experimentally demonstrated and has obvious evolutionary value. However, this hypothesis lacks experimentally verified mechanisms although ideas relating to this issue are presented. Finally, the ideas surrounding the broad hypothesis that sleep serves a connectivity/plasticity function are many and attractive. There is experimental evidence that connectivity changes with sleep, sleep loss, and with changing afferent input, and that those changes are linked to sleep regulatory mechanisms. In our view, this is the leading contender for the primordial function of sleep. However, much refinement of ideas and innovative experimental approaches are needed to clarify the sleep-connectivity relationship.

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Rapid eye movement sleep promotes cortical plasticity in the developing brain

Abstract: Rapid eye movement sleep plays a critical role in shaping developing circuits in the cerebral cortex.

Cited by 127 publications

References 28 publications

Neuroscience: A Distributed Neural Network Controls REM Sleep

Neuroscience: A Distributed Neural Network Controls REM Sleep

Sleep, synaptic homeostasis and neuronal firing rates

Sleep function: Toward elucidating an enigma

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