Rapid diagnosis of pedal osteomyelitis in diabetics with a technetium-99m-labeled monoclonal antigranulocyte antibody

Palestro, Christopher J.; Caprioli, Russell; Love, Charito; Richardson, Hugh; Kipper, Samuel L.; Weiland, Frederick L.; Tomas, Maria B.

doi:10.1053/jfas.2003.0420001

Cited by 55 publications

(30 citation statements)

References 10 publications

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“…Overall, expect a good clinical response (i.e., resolution of clinical evidence of infection) to appropriate therapy in 80%-90% of mild-to-moderate infections [84,121,130,263] and in 60%-80% of severe infections or cases of osteomyelitis [130,145,147,237,283]. Factors associated with a poor outcome include signs of systemic infection [237], inadequate limb perfusion, osteomyelitis [273,[283][284][285], the presence of necrosis or gangrene [276], an inexperienced surgeon [286], and proximal location of the infection [287].…”

Section: Discussionmentioning

confidence: 99%

“…Additional imaging studies. MRI is the preferred imaging study, with nuclear medicine scans (that preferably use newer generation leukocyte [239,261,262] or immunoglobulin [263,264] techniques) being a second choice. If results of the imaging tests are negative, osteomyelitis is unlikely; if results suggest osteomyelitis, consider whether bone biopsy is needed (vide infra).…”

Section: Osteomyelitismentioning

confidence: 99%

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Diagnosis and Treatment of Diabetic Foot Infections

Lipsky

Berendt

Deery

et al. 2005

JAPMA

117

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Section: Discussionmentioning

confidence: 99%

Section: Osteomyelitismentioning

confidence: 99%

Diagnosis and Treatment of Diabetic Foot Infections

Lipsky

Berendt

Deery

et al. 2005

JAPMA

117

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“…Newer methods of labelling white cells are promising [23,24], as are scans using labelled anti-neutrophil antibodies [25,26]. In most instances, leucocyte scans are currently used only when magnetic resonance imaging scans (MRI) are unavailable.…”

Section: Radionuclide White Blood Cell Scansmentioning

confidence: 99%

Diabetic foot osteomyelitis: a progress report on diagnosis and a systematic review of treatment

Berendt

Peters

Баккер³

et al. 2008

Diabetes Metab. Res. Rev.

276

214

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SummaryThe International Working Group on the Diabetic Foot appointed an expert panel to provide evidence-based guidance on the management of osteomyelitis in the diabetic foot. Initially, the panel formulated a consensus scheme for the diagnosis of diabetic foot osteomyelitis (DFO) for research purposes, and undertook a systematic review of the evidence relating to treatment. The consensus diagnostic scheme was based on expert opinion; the systematic review was based on a search for reports of the effectiveness of treatment for DFO published prior to December 2006.The panel reached consensus on a proposed scheme that assesses the probability of DFO, based on clinical findings and the results of imaging and laboratory investigations.The literature review identified 1168 papers, 19 of which fulfilled criteria for detailed data extraction. No significant differences in outcome were associated with any particular treatment strategy. There was no evidence that surgical debridement of the infected bone is routinely necessary. Culture and sensitivity of isolates from bone biopsy may assist in selecting properly targeted antibiotic regimens, but empirical regimens should include agents active against staphylococci, administered either intravenously or orally (with a highly bioavailable agent). There are no data to support the superiority of any particular route of delivery of systemic antibiotics or to inform the optimal duration of antibiotic therapy. No available evidence supports the use of any adjunctive therapies, such as hyperbaric oxygen, granulocyte-colony stimulating factor or larvae.We have proposed a scheme for diagnosing DFO for research purposes. Data to inform treatment choices in DFO are limited, and further research is urgently needed.

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“…Although some have yielded promising results in early studies, none has yet emerged as a robust and useful test for general application [45][46][47][48][49][50].…”

Section: Scintigraphymentioning

confidence: 99%

Diagnosing and treating diabetic foot infections

Lipsky

Berendt

Embil

et al. 2004

Diabetes Metab. Res. Rev.

111

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Foot infections are a common, complex and costly complication of diabetes. We have made considerable progress in establishing consensus definitions for defining infection. Similarly, we have learned much about the appropriate ways to diagnose both soft tissue and bone infections. Accompanying these advances have been improvements in our knowledge of the proper approaches to antibiotic (and surgical) therapy for diabetic foot infections. Furthermore, investigators have explored the value of various adjunctive therapies, especially granulocyte colony stimulating factors and hyperbaric oxygen, for improving outcomes. This paper presents a summary of a minisymposium on infection of the diabetic foot that was held at the fourth International Symposium on the Diabetic Foot, in Noordwijkerhout, The Netherlands.

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Rapid diagnosis of pedal osteomyelitis in diabetics with a technetium-99m-labeled monoclonal antigranulocyte antibody

Cited by 55 publications

References 10 publications

Diagnosis and Treatment of Diabetic Foot Infections

Diagnosis and Treatment of Diabetic Foot Infections

Diabetic foot osteomyelitis: a progress report on diagnosis and a systematic review of treatment

Diagnosing and treating diabetic foot infections

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