Rapid diagnosis of malignant pleural mesothelioma and its discrimination from lung cancer and benign exudative effusions using blood serum

Yonar, Dilek; Severcan, Mete; Gurbanov, Rafig; Sandal, Abdülsamet; Yılmaz, Ülkü; Emri, Salïh; Severcan, Feride

doi:10.1016/j.bbadis.2022.166473

Cited by 16 publications

(14 citation statements)

References 69 publications

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“…The area values under the spectral bands are proportional to the concentration of the respective molecules /the functional groups in the samples. Information about the relative concentration of the respective molecules in the samples can be obtained by the band area/band intensity analysis (Bayarı et al, 2020;Akgun et al, 2021;Yonar et al, 2022). The infrared integrated band area ratios to evaluate spectroscopic data and their suggestions are listed in Table 1.…”

Section: Atr-ftir Spectral Data Collection and Data Analysismentioning

confidence: 99%

“…The authors proposed that hypoallergenic formulas do not have in vitro TGF-β activity and have lower anti-inflammatory activity in comparison with regular ones (Panahipour et al, 2020). Infrared (IR) spectroscopy is a technique that has been applied (mid-infrared (MIR) and nearinfrared (NIR)) in many fields such as food, agriculture, medicine, biomedical applications, and chemistry (Linker, 2011;Gok et al, 2015;Bayari et al, 2020, Baltacioglu, 2022Yonar et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

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Standart Ve Hi̇poalerjeni̇k Bebek Sütü Formülleri̇ni̇n Atr-Ftir Spektroskopi̇si̇ Ve Çok Değişkenli̇ Anali̇z Yöntemleri̇yle İncelenmesi̇

Yonar

Bayarı

2023

Gıda

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Infant formulas contain nutrients and bioactive ingredients designed to meet the nutrition requirements of infants. The majority of infant formulas are cow's milk (CM) based regular ones. Since CM is one of the most important allergen source, there are specialized formulas such as partially and extensively hydrolyzed, aminoacid‐based for CM‐allergic infants. In the current study, attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR) in combination with multivariate analysis was used to identify the molecular differences between commercially available hypoallergenic (HF) and regular formulas (RF) in Turkey. Higher saturated fatty acid (FA) content and qualitatively longer acyl chained FAs were observed in hypoallergenic formulations. The results of hierarchical cluster analysis (HCA) and principal component analysis (PCA) showed that there were differences between the infrared spectra of the two groups. The HF and RF samples were clearly separated from each other in 1200-800 cm-1 spectral region with 83% variation and 100% accuracy.

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Section: Atr-ftir Spectral Data Collection and Data Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Standart Ve Hi̇poalerjeni̇k Bebek Sütü Formülleri̇ni̇n Atr-Ftir Spektroskopi̇si̇ Ve Çok Değişkenli̇ Anali̇z Yöntemleri̇yle İncelenmesi̇

Yonar

Bayarı

2023

Gıda

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“…It captures the vibrations of molecules to form spectral bands in the mid-IR region 10,11 Combined with machine learning and other statistic data processing methods, the technique has been shown to be a promising tool in the diagnosis of diverse diseases. [12][13][14] This study aims to investigate the therapeutic potential of young plasma in intestinal ageing. We hypothesize that young plasma can rejuvenate the biomolecular profile and structural integrity of aged rat ileum and colon tissues.…”

Section: Introductionmentioning

confidence: 99%

“…Infrared (IR) spectroscopy, a powerful tool for biological analyses, uses its multiprocessing abilities to gather extensive data rapidly and non‐invasively. It captures the vibrations of molecules to form spectral bands in the mid‐IR region 10,11 Combined with machine learning and other statistic data processing methods, the technique has been shown to be a promising tool in the diagnosis of diverse diseases 12–14 …”

Section: Introductionmentioning

confidence: 99%

The rejuvenating influence of young plasma on aged intestine

Ceylani,

Teker,

Keskin

et al. 2023

J Cellular Molecular Medi

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This study aims to investigate the effects of plasma exchange on the biomolecular profiles and histology of ileum and colon tissues in young and aged Sprague–Dawley male rats. Fourier transform infrared (FTIR) spectroscopy, linear discriminant analysis and support vector machine (SVM) techniques were employed to analyse the lipid, protein, and nucleic acid indices in young and aged rats. Following the application of young plasma, aged rats demonstrated biomolecular profiles similar to those of their younger counterparts. Histopathological and immunohistochemical assessments showed that young plasma had a protective effect on the intestinal tissues of aged rats, increasing cell density and reducing inflammation. Additionally, the expression levels of key inflammatory mediators tumour necrosis factor‐alpha and cyclooxygenase‐2 significantly decreased after young plasma administration. These findings underscore the therapeutic potential of young plasma for mitigating age‐related changes and inflammation in the intestinal tract. They highlight the critical role of plasma composition in the ageing process and suggest the need for further research to explore how different regions of the intestines respond to plasma exchange. Such understanding could facilitate the development of innovative therapies targeting the gastrointestinal system, enhancing overall health during ageing.

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“…By identifying specific spectral markers, it is possible to have an efficient diagnosis [12]. Thus, different cancers can be detected by plasma or serum analysis [13], including hepatocellular carcinoma [14], brain [15,16], breast [17], ovarian [18], prostate [19], pleural [20], and oral [21] cancer. In addition, sputum [22] or saliva [23] can be used for lung diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Identification of circulating biomarkers of Crohn's disease and spondyloarthritis using Fourier transform infrared spectroscopy

Prada

Brunel

Moulin

et al. 2022

Journal of Biophotonics

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Crohn's disease (CD) and spondyloarthritis (SpA) are two inflammatory diseases sharing many common features (genetic polymorphism, armamentarium). Both diseases lack diagnostic markers of certainty. While the diagnosis of CD is made by a combination of clinical, and biological criteria, the diagnosis of SpA may take several years to be confirmed. Based on the hypothesis that CD and SpA alter the biochemical profile of plasma, the objective of this study was to evaluate the analytical capability of Fourier transform infrared spectroscopy (FTIR) in identifying spectral biomarkers. Plasma from 104 patients was analyzed. After data processing of the spectra by Extended Multiplicative Signal Correction and linear discriminant analysis, we demonstrated that it was possible to distinguish CD and SpA from controls with an accuracy of 97% and 85% respectively. Spectral differences were mainly associated with proteins and lipids. This study showed that FTIR analysis is efficient to identify plasma biosignatures specific to CD or SpA.

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Rapid diagnosis of malignant pleural mesothelioma and its discrimination from lung cancer and benign exudative effusions using blood serum

Cited by 16 publications

References 69 publications

Standart Ve Hi̇poalerjeni̇k Bebek Sütü Formülleri̇ni̇n Atr-Ftir Spektroskopi̇si̇ Ve Çok Değişkenli̇ Anali̇z Yöntemleri̇yle İncelenmesi̇

Standart Ve Hi̇poalerjeni̇k Bebek Sütü Formülleri̇ni̇n Atr-Ftir Spektroskopi̇si̇ Ve Çok Değişkenli̇ Anali̇z Yöntemleri̇yle İncelenmesi̇

The rejuvenating influence of young plasma on aged intestine

Identification of circulating biomarkers of Crohn's disease and spondyloarthritis using Fourier transform infrared spectroscopy

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