Rapid Development of Hydrophilicity and Protein Adsorption Resistance by Polymer Surfaces Bearing Phosphorylcholine and Naphthalene Groups

Futamura, Koji; Matsuno, Ryosuke; Konno, Tomohiro; Takai, Madoka; Ishihara, Kazuhíko

doi:10.1021/la801017h

Cited by 70 publications

(67 citation statements)

References 24 publications

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“…In previous reports, the surface restructuring of the PMB in water, which results in the increased directionality of the hydrophilic MPC chains, has been used to explain the contact angle hysteresis (∼40°) between the air and water. 6,45 Previous studies about PEG−PMB showed that the swelling of the hydrophilic PEG may lead to a slight increase in the contact angle hysteresis in addition to the reorientation effect of the PMB segments. 6 Moreover, the hydrated loop-type PEG segment in the middle of the block copolymer was found to increase the molecular mobility.…”

Section: Methodsmentioning

confidence: 99%

Structural Reorganization and Fibrinogen Adsorption Behaviors on the Polyrotaxane Surfaces Investigated by Sum Frequency Generation Spectroscopy

Seo

Qiao

et al. 2015

ACS Appl. Mater. Interfaces

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Polyrotaxanes, such as supramolecular assemblies with methylated α-cyclodextrins (α-CDs) as host molecules noncovalently threaded on the linear polymer backbone, are promising materials for biomedical applications because they allow adsorbed proteins possessing a high surface flexibility as well as control of the cellular morphology and adhesion. To provide a general design principle for biomedical materials, we examined the surface reorganization behaviors and adsorption conformations of fibrinogen on the polyrotaxane surfaces with comparison to several random copolymers by sum frequency generation (SFG) vibrational spectroscopy. We showed that the polyrotaxane (OMe-PRX-PMB) with methylated α-CDs as the host molecule exhibited unique surface structures in an aqueous environment. The hydrophobic interaction between the methoxy groups of the methylated α-CD molecules and methyl groups of the n-butyl methacrylate (BMA) side chains may dominate the surface restructuring behavior of the OMe-PRX-PMB. The orientation analysis revealed that the orientation of the fibrinogen adsorbed on the OMe-PRX-PMB surface is close to a single distribution, which is different from the adsorption behaviors of fibrinogen on other polyrotaxane or random copolymer surfaces.

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Section: Methodsmentioning

confidence: 99%

Structural Reorganization and Fibrinogen Adsorption Behaviors on the Polyrotaxane Surfaces Investigated by Sum Frequency Generation Spectroscopy

Seo

Qiao

et al. 2015

ACS Appl. Mater. Interfaces

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“…The surface is dynamic; thus, surface equilibrium with aqueous media is necessary to orient the polar PC groups in the MPC units at the surface [35]. To shorten the equilibrium period, the mobility of the PC groups has been studied as a function of the chemical structure of monomer [35,36], solvent composition [37], and types of comonomers [38]. For example, polydimethylsiloxane (PDMS) is one of the most commonly used materials.…”

Section: Coating Of Artificial Materials With Mpc Polymersmentioning

confidence: 99%

Cell membrane-inspired phospholipid polymers for developing medical devices with excellent biointerfaces

Iwasaki

Ishihara

2012

Science and Technology of Advanced Materials

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260

216

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This review article describes fundamental aspects of cell membrane-inspired phospholipid polymers and their usefulness in the development of medical devices. Since the early 1990s, polymers composed of 2-methacryloyloxyethyl phosphorylcholine (MPC) units have been considered in the preparation of biomaterials. MPC polymers can provide an artificial cell membrane structure at the surface and serve as excellent biointerfaces between artificial and biological systems. They have also been applied in the surface modification of some medical devices including long-term implantable artificial organs. An MPC polymer biointerface can suppress unfavorable biological reactions such as protein adsorption and cell adhesion -in other words, specific biomolecules immobilized on an MPC polymer surface retain their original functions. MPC polymers are also being increasingly used for creating biointerfaces with artificial cell membrane structures.

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“…This is the main impetus for developing methods such as plasma treatment to increase wettability of hydrophobic biomedical surfaces. [38][39][40][41] In the current study, the inhibitory effect of low-molecularweight PDMA brushes on platelet activation partially correlated with surface wettability. As shown in Table 1, samples S1 to S4 show water contact angles from high to low, indicating an increase in wettability, which corresponds well to the changes in platelet activation.…”

Section: Discussionmentioning

confidence: 70%

Inhibitory Effect of Hydrophilic Polymer Brushes on Surface‐Induced Platelet Activation and Adhesion

Zou

Lai

Kizhakkedathu

et al. 2010

Macromolecular Bioscience

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Poly(N,N-dimethylacrylamide) (PDMA) brushes are successfully grown from unplasticized poly(vinyl chloride) (uPVC) by well-controlled surface-initiated atom transfer radical polymerization (SI-ATRP). Molecular weights of the grafted PDMA brushes vary from ≈ 35,000 to 2,170000 Da, while the graft density ranges from 0.08 to 1.13 chains · nm(-2). The polydispersity of the grafted PDMA brushes is controlled within 1.20 to 1.80. Platelet activation (expression of CD62) and adhesion studies reveal that the graft densities of the PDMA brushes play an important role in controlling interfacial properties. PDMA brushes with graft densities between 0.35 and 0.50 chains · nm(-2) induce a significantly reduced platelet activation compared to unmodified uPVC. Moreover, the surface adhesion of platelets on uPVC is significantly reduced by the densely grafted PDMA brushes. PDMA brushes that have high molecular weights lead to a relatively lower platelet activation compared to low-molecular-weight brushes. However, the graft density of the brush is more important than molecular weight in controlling platelet interactions with PVC. PDMA brushes do not produce any significant platelet consumption in platelet rich plasma. Up to a seven-fold decrease in the number of platelets adhered on high graft density brushes is observed compared to the bare PVC surface. Unlike the bare PVC, platelets do not form pseudopodes or change morphology on PDMA brush-coated surfaces.

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Rapid Development of Hydrophilicity and Protein Adsorption Resistance by Polymer Surfaces Bearing Phosphorylcholine and Naphthalene Groups

Cited by 70 publications

References 24 publications

Structural Reorganization and Fibrinogen Adsorption Behaviors on the Polyrotaxane Surfaces Investigated by Sum Frequency Generation Spectroscopy

Structural Reorganization and Fibrinogen Adsorption Behaviors on the Polyrotaxane Surfaces Investigated by Sum Frequency Generation Spectroscopy

Cell membrane-inspired phospholipid polymers for developing medical devices with excellent biointerfaces

Inhibitory Effect of Hydrophilic Polymer Brushes on Surface‐Induced Platelet Activation and Adhesion

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