Rapid determination of trace nitrophenolic organics in water by combining solid-phase extraction with surface-assisted laser desorption/ionization time-of-flight mass spectrometry

Chen, Yu-Chie; Shiea, Jentaie; Sunner, Jan

doi:10.1002/(sici)1097-0231(20000130)14:2<86::aid-rcm839>3.0.co;2-o

Cited by 40 publications

(37 citation statements)

References 25 publications

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“…Several approaches have been developed to directly couple planar separations to MALDI: (i) introduction of solid MALDI matrix in solution [154,155], (ii) spraying the MALDI matrix solution onto the surface [156], and (iii) transfer of analyte to another membrane or support [157,158,159,160]. Although TLC-MALDI as well as optimization of the coupling protocol has been extensively reviewed [141,142], a few recent examples will further illustrate the potential of direct coupling for the characterization of LMW samples.…”

Section: Separations -Maldimentioning

confidence: 99%

Small molecule analysis by MALDI mass spectrometry

2002

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This review focuses on the application of matrix assisted laser desorption/ionization (MALDI) mass spectrometry to the characterization of molecules in the low mass range (<1500 Da). Despite its reputation to the contrary, MALDI is a powerful technique to provide both qualitative and quantitative determination of low molecular weight compounds. Several approaches to minimize interference via sample preparation and matrix selection are discussed, as well as coupling of MALDI to liquid and planar chromatographic techniques to extend its range of applicability.

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Section: Separations -Maldimentioning

confidence: 99%

Small molecule analysis by MALDI mass spectrometry

2002

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“…A range of techniques has been developed to overcome the matrix problems in analysis of small molecules, including the use of desorption ionization from porous silicon (DIOS) [3], polymeric matrices [4], inorganic materials [5], high-molecular-weight matrices [6], surfactantsuppressed matrices [7], and carbon allotropes. Carboneous materials such as carbon nanotubes [8], activated carbon [9], graphite [10], and, recently, graphitized carbon black (GCB) [11] have been shown to provide suitable media for surface-assisted laser desorption ionization (SALDI) and have been used in various formats for different applications. Among these techniques DIOS is the most widely used, although it suffers from oxidation of surface groups and degradation of performance when stored in air for extended periods of time [12].…”

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confidence: 99%

SALDI-MS Signal enhancement using oxidized graphitized carbon black nanoparticles

Amini

Shariatgorji

Thorsén

2009

J. Am. Soc. Mass Spectrom.

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The signal intensity of low-molecular-weight compounds analyzed using surface-assisted laser desorption/ionization time-of-flight mass spectrometry (SALDI-TOF-MS) was significantly enhanced when oxidized graphitized carbon black (GCB) particles were used as the desorption/ionization surface. The surface of oxidized GCB contains more carboxylic acid groups than non-oxidized GCB. Carboxylic acid groups enhance the efficiency of the ionization process and the desorption of more hydrophobic compounds. A common pharmaceutical compound, propranolol, was successfully extracted from Baltic Sea blue mussels and quantified using oxidized GCB as the SALDI surface, whereas deuterated propranolol was used as the internal standard. The calibration curve showed a wide linear dynamic range of response (0.1-20 g/mL) and good reproducibility (RSD Ͻ 10%). It was not possible to detect propranolol in Baltic Sea blue mussels when non-oxidized GCB was used as the SALDI surface. (J Am Soc Mass

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“…Recently, MALDI-TOF-MS has also been developed to analyze small molecules [13] successfully by using the different matrix substances, such as desorption/ionization on porous silicon (DIOS) [14 -17], matrix with high molecular weight [18,19], surfactant suppressed matrix [20], inorganic materials [21][22][23][24][25], etc. Though considerable works of quantitative determination using MALDI have been well documented and reviewed [26], quantitative analysis by MALDI is still considered as a relatively unreliable technique for the limiting factor of reproducibility within and between sample spots.…”

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confidence: 99%

Using oxidized carbon nanotubes as matrix for analysis of small molecules by MALDI-TOF MS

Pan

et al. 2005

J. Am. Soc. Mass Spectrom.

154

147

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Oxidized carbon nanotubes are tested as a matrix for analysis of small molecules by matrix assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF-MS). Compared with nonoxidized carbon nanotubes, oxidized carbon nanotubes facilitate sample preparation because of their higher solubility in water. The matrix layer of oxidized carbon nanotubes is much more homogeneous and compact than that of nonoxidized carbon nanotubes. The efficiency of desorption/ionization for analytes and the reproducibility of peak intensities within and between sample spots are greatly enhanced on the surface of oxidized carbon nanotubes. The advantage of the oxidized carbon nanotubes in comparison with ␣-cyano-4-hydroxycinnamic acid (CCA) and carbon nanotubes is demonstrated by MALDI-TOF-MS analysis of an amino acid mixture. The matrix is successfully used for analysis of synthetic hydroxypropyl ␤-cyclodextrin, suggesting a great potential for monitoring reactions and for product quality control. Reliable quantitative analysis of jatrorrhizine and palmatine with a wide linear range (1-100 ng/mL) and good reproducibility of relative peak areas (RSD less than 10%) is achieved using this matrix. Concentrations of jatrorrhizine (8.65 mg/mL) and palmatine (10.4 mg/mL) in an extract of Coptis chinensis Franch are determined simultaneously using the matrix and a standard addition method. [27] developed a method for quantitative analysis of small molecules with desorption/ionization on porous silicon using electrospray deposition of analytes, and a quite good quantitative result with linear calibrations R 2 Ͼ 0.99 and values of RSD Ͻ 7% was achieved. It is believed that MALDI could be a powerful technique to provide both qualitative and quantitative determination of small compounds.Carbon nanotubes have been attracting wide interest [28,29] of scientists since they were initially discovered by Iijima et al. [30,31]. Recently, Carbon nanotubes have been developed as the matrix for MALDI-TOF-MS for analysis of small molecules [25], in which carbon nanotubes function both as the energy receptacle for laser radiation and as the energy transporter for desorption/ionization of analytes with the minimization of interference signals caused by matrix ion. The effectiveness of the method as matrix has been demonstrated by several compounds with low molecular weight. However, the low solubility of carbon nanotubes in water or organic solvent makes it hard to deposit carbon nanotubes onto the sample target and to form a homogeneous layer of matrix, leading to the relatively poor reproducibility and resolution of peaks for analytes.

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Rapid determination of trace nitrophenolic organics in water by combining solid-phase extraction with surface-assisted laser desorption/ionization time-of-flight mass spectrometry

Cited by 40 publications

References 25 publications

Small molecule analysis by MALDI mass spectrometry

Small molecule analysis by MALDI mass spectrometry

SALDI-MS Signal enhancement using oxidized graphitized carbon black nanoparticles

Using oxidized carbon nanotubes as matrix for analysis of small molecules by MALDI-TOF MS

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