Rapid determination of the antiparasitic drugs flubendazole and febantel in feeds by HPLC with ultraviolet detection

Dusi, Guglielmo; Gamba, Valentina; Faggionato, Elena

doi:10.1016/j.jpba.2005.01.010

Cited by 12 publications

(7 citation statements)

References 10 publications

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“…The anthelmintic efficacy of ABZ (Tucker, Yazwinski, Reynolds, Johnson, & Keating, 2007) and FBZ (Norton, Yazwinski, & Johnson, 1991;Taylor, Kenny, Houston, & Hewitt, 1993) has been demonstrated in chickens and hens and there are evidences of their use in different avian production systems (Dusi, Gamba, & Faggionato, 2005). It is well known that after administration of ABZ or FBZ in chicken, plasma concentration of both parent drug and their sulphoxide and sulphone metabolites were quantified (Csiko et al, 1996;Taylor et al, 1993).Therefore, it is likely that after their administration to chickens or laying hens, drug residues appear in meat and eggs.…”

Section: Application Of the Developed Methodsmentioning

confidence: 99%

Multiresidue HPLC method to measure benzimidazole anthelmintics in plasma and egg from laying hens. Evaluation of albendazole metabolites residue profiles

et al. 2011

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Section: Application Of the Developed Methodsmentioning

confidence: 99%

Multiresidue HPLC method to measure benzimidazole anthelmintics in plasma and egg from laying hens. Evaluation of albendazole metabolites residue profiles

et al. 2011

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“…Many analytical and bioanalytical methods have been reported in literature for determination of febantel alone or in combination with other benzimidazoles. Literature shows few HPLC methods for quantification of febantel from veterinary preparations [8,9], feeds [10]. There are liquid chromatographic methods for determination of febantel in biological matrices [11][12][13][14][15] and fate of anthelmintics in environment [16,17].…”

Section: Introductionmentioning

confidence: 99%

Characterization and toxicity evaluation of degradation products of febantel

Mahajan¹,

Marathe²,

Jarande³

et al. 2020

Futur J Pharm Sci

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Background The aim of the present work was to determine potential toxicity of degradation products of febantel generated under different stress conditions mentioned in guideline Q1A (R2) laid down by International Council for Harmonization (ICH). The stability behavior of febantel was studied by subjecting it to hydrolytic, oxidative, photolytic and thermal forced degradation conditions. Results Five degradation products (DPs) were observed which were resolved using high-performance liquid chromatography (HPLC) and characterized by LC-MS/MS using positive mode of electrospray ionization. The chromatographic separation was carried out on Hypersil® BDS C18 (150 × 4.6 mm, 5 μm) column. Optimum resolution was obtained using ammonium formate buffer (10 mM, pH 3.5) and acetonitrile programmed in gradient elution mode at 281.0 nm using photodiode array detector. Conclusion The drug was found susceptible to degradation under all the stress conditions except thermal and oxidative stress. Five major unknown degradation products DP–I, DP–II, DP–III, DP–IV, and DP–V generated under photolytic, alkali, and acidic stress condition were identified and characterized by LC-MS/MS. The drug and identified degradation products were screened for prediction of in-silico toxicity using software viz. Swiss ADME, OSIRIS Property Explorer and Pro Tox II which indicated overall no toxicological concerns. Graphical abstract

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“…Reported methods include determination of FBT in combination with the other anthelmintic drugs like flubendazole, oxfendazole and oxfendazole sulfone etc. These include High performance liquid chromatography (HPLC) (Dusi et al, 2005;Wanda and Anna, 2010;Delatour et al, 1983;Landuyt et al, 1993;Chou et al, 2004) with ultraviolet (UV) (Kawasaki et al, 1999) or gas chromatography/mass spectrometry (GC/MS) (Wilson et al, 1991). So far there is no visible spectrophotometric method developed for the analysis of FBT in pure and dosage forms.…”

Section: Introductionmentioning

confidence: 99%

A novel spectrophotometric approach for the determination of febantel in pure and dosage forms

Divya

Narayana

2016

Journal of the Association of Arab Universities for Basic and A

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A new, simple, accurate and rapid spectrophotometric method was developed for the quality control of febantel (FBT), in pure and dosage forms. The method was based on the utility of p-acceptors such as 3,6-dichloro-2,5-dihydroxy-p-benzoquinone (CAA) or 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) for the determination of FBT which act as an e-donor to form a highly colored complex with absorption bands at 524 and 579 nm, respectively. The applicability of the method was demonstrated by the determination of the studied drug in commercial tablets and the results were statistically evaluated as per the ICH guidelines. The new spectrophotometric method described in this paper is fast, convenient and has the novelty of carrying out the quantitative determination of FBT in pure and dosage forms. ª 2014 Production and hosting by Elsevier B.V. on behalf of University of Bahrain.

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Rapid determination of the antiparasitic drugs flubendazole and febantel in feeds by HPLC with ultraviolet detection

Cited by 12 publications

References 10 publications

Multiresidue HPLC method to measure benzimidazole anthelmintics in plasma and egg from laying hens. Evaluation of albendazole metabolites residue profiles

Multiresidue HPLC method to measure benzimidazole anthelmintics in plasma and egg from laying hens. Evaluation of albendazole metabolites residue profiles

Characterization and toxicity evaluation of degradation products of febantel

A novel spectrophotometric approach for the determination of febantel in pure and dosage forms

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