A novel spectrophotometric approach for the determination of febantel in pure and dosage forms

Abstract

A new, simple, accurate and rapid spectrophotometric method was developed for the quality control of febantel (FBT), in pure and dosage forms. The method was based on the utility of p-acceptors such as 3,6-dichloro-2,5-dihydroxy-p-benzoquinone (CAA) or 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) for the determination of FBT which act as an e-donor to form a highly colored complex with absorption bands at 524 and 579 nm, respectively. The applicability of the method was demonstrated by the determination of the studied drug in commercial tablets and the results were statistically evaluated as per the ICH guidelines. The new spectrophotometric method described in this paper is fast, convenient and has the novelty of carrying out the quantitative determination of FBT in pure and dosage forms. ª 2014 Production and hosting by Elsevier B.V. on behalf of University of Bahrain.

Characterization and toxicity evaluation of degradation products of febantel

“…There are liquid chromatographic methods for determination of febantel in biological matrices [11][12][13][14][15] and fate of anthelmintics in environment [16,17]. Various assay methods are also available based on determination by LC and GC-MS [18], HPLC-MS/MS [19][20][21], UV spectrophotometry [22,23], IR, thermogravimetry, and scanning electron microscopy [24,25]. Little information is available on study involving photodegradation [26,27] and biodegradation [28] of febantel.…”

Spectrophotometric method for pregabalin determination: An experimental design approach for method development

“…The reagents include potassium iodate and potassium iodide (Gujral et al, 2009), fluorescamine, 2,4-diclorofluorobenzene and 2,3,5,6-tetrachloro-1, 4-benzoquinone (Shaalan, 2010), ninhydrin (Bali and Gaur, 2011), 1,2-naphthoquinone-4-sulfonate and 2,4-dinitrofluoro benzene (Walash et al, 2011), ascorbic acid and salicylaldehyde (Hammad and Abdallah, 2012) and bromocresol green (Merin et al, 2013). In the current literature Ismail et al (2014) and Kumble and Narayana (2014) also developed spectrophotometric methods for the determination of bifonazole and febantel, respectively. In methods mentioned in the foregoing, the experimental variables, such as the reagent concentration, reagent volume, heating temperature, heating time and pH of the reaction mixture were optimized using the one variable at a time method (OVAT).…”