Rapid determination of quinolones in cosmetic products by ultra high performance liquid chromatography with tandem mass spectrometry

Abstract

This study developed an improved analytical method for the simultaneous quantification of 13 quinolones in cosmetics by ultra high performance liquid chromatography combined with ESI triple quadrupole MS/MS under the multiple reaction monitoring mode. The analytes were extracted and purified by using an SPE cartridge. The limits of quantification ranged from 0.03 to 3.02 μg/kg. The precision for determining the quinolones was <19.39%. The proposed method was successfully developed for the determination of quinolones in real cosmetic samples.

Current trends in sample preparation for cosmetic analysis

“…Many types of commercially available SPE columns have been employed to extract the allowed and prohibited substances in cosmetics. Coumarin derivatives and quinolones were extracted using Oasis HLB , n ‐nitrosodiethanolamines were extracted with Bond Elut Accu CAT , hexapeptides were extracted using HILIC , dexpanthenols were extracted by Adsorbex NH 2 , fullerenes were extracted using Strata C‐18 E , and semipermanent dyes were extracted with Strata‐X cartridges . The results demonstrated that the proposed procedures can obtain high extraction efficiency.…”

Direct identification of prohibited substances in cosmetics and foodstuffs using ambient ionization on a miniature mass spectrometry system

“…For cosmetic products, illicit substances are also added to enhance short-term cosmetic effectiveness. Common banned additives include antibiotics [10, 11], corticosteroids [12–15], sexual hormones (oestrogens [16], progestogens [16], androgen [17]), pharmacologically active substances [16–18], prohibited preservatives (parabens [19–22], methyldibromoglutaronitrile [23]), whitening agents [13, 24], phthalates [25–28], and nitromusk fragrances [25, 28]. Long-term exposure to these substances could cause adverse effects such as skin irritation, allergic reactions, and antibiotic resistance, which represents a severe risk to public health.…”

“…The analytical techniques that have been reported for the chemical analysis of foods and cosmetic products include thin layer chromatography [29, 30], capillary electrophoresis [22, 31], gas chromatography (GC) with flame ionization detection [21, 32] or coupled with various types of mass spectrometers [19, 20, 23, 25, 26, 28, 33–36], high-performance liquid chromatography (HPLC) using ultraviolet [10, 12, 16, 17, 24, 37], electrochemical detection [38] or coupled with various types of mass spectrometers [1, 11–17, 26, 35, 39]. These methods are typically implemented in analytical laboratories and performed by experienced chemists using bench-top equipment.…”

Comparison of extraction solvents and sorbents in the quick, easy, cheap, effective, rugged, and safe method for the determination of pesticide multiresidue in fruits by ultra high performance liquid chromatography with tandem mass spectrometry

“…To date modern UHPLC–MS/MS equipment is used for precise and accurate analyte determination, which has following advantages: higher level of selectivity and sensitivity, applicability for fast qualitative screening and for precise quantitative analysis . We have determined a variety of chemical residues, such as carbamates, mycotoxins, and antibiotics by UHPLC–MS/MS in our previous studies . In this study, several plant growth regulators and fungicides in fruits were analyzed.…”