Rapid determination of acetaminophen and p-aminophenol in pharmaceutical formulations using miniaturized capillary electrophoresis with amperometric detection

Chu, Qingcui; Jiang, Lianmei; Tian, Xin; Ye, Jiannong

doi:10.1016/j.aca.2007.11.015

Cited by 146 publications

(55 citation statements)

References 27 publications

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“…Acetaminophen (paracetamol, N-acetyl-p-aminophenol, AC) ( Figure 1b) is an extensively used antipyretic analgesic drug and a suitable alternative for patients who are sensitive to aspirin [13]. To date, various methods have been developed for the detection AC such as HPLC [14], spectrophotometry [15], and electrophoresis [16]. Alternatively, electrochemical methods have also received much interest due to their higher selectivity, lower cost, and faster operation than other methods.…”

Section: Introductionmentioning

confidence: 99%

Design of a New Carbon Paste Electrode Modified with TiO₂ Nanoparticles to Use in an Electrochemical Study of Codeine and Simultaneous Determination of Codeine and Acetaminophen in Human Plasma Serum Samples

Mashhadizadeh

Rasouli

2014

Electroanalysis

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A new electrochemical sensor was fabricated via TiO2 nanoparticles onto a carbon paste electrode. Cyclic voltammetry (CV) and differential pulse voltammetry (DPV) studied the response of the modified electrode toward codeine. The effects of pH, modifier amount, pulse amplitude, and scan rate of potential have been examined. Using DPV, we could measure simultaneously codeine and acetaminophen in one mixture. The detection limits of 0.018 and 0.050 µmol L−1 were achieved for codeine and acetaminophen, respectively. The electrooxidation pathway, transfer coefficient, and standard rate constant, are estimated. The proposed voltammetric sensor was successfully applied to determination of codeine and acetaminophen in human plasma serum samples.

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Section: Introductionmentioning

confidence: 99%

Design of a New Carbon Paste Electrode Modified with TiO₂ Nanoparticles to Use in an Electrochemical Study of Codeine and Simultaneous Determination of Codeine and Acetaminophen in Human Plasma Serum Samples

Mashhadizadeh

Rasouli

2014

Electroanalysis

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“…This increases robustness and portability. A miniaturized CE system with AmpD was presented by Chu et al for several applications (e.g., determination of sugars in Coke [98], acetaminophen and p-amino-phenol [99], uric acid in human saliva and urine [100] and bioactive amines [101]). This system was a chipbased design, where an 8.5 cm long capillary was placed on a Plexiglass plate (25 mm x 100 mm x 2 mm).…”

Section: Capillarymentioning

confidence: 99%

“…Miniaturized AmpD has been presented in number of papers [96,[98][99][100][101][107][108][109][110]. The preferred arrangement is based on placing the detection and the separation (capillary) part on the microscope plate, which limits size and increases compactness.…”

Section: Electrochemicalmentioning

confidence: 99%

Portable capillary-based (non-chip) capillary electrophoresis

Ryvolová

Preisler

Brabazon

et al. 2010

TrAC Trends in Analytical Chemistry

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Miniaturized, portable instrumentation has been gaining popularity in all areas of analytical chemistry. Capillary electrophoresis (CE), due to its main strengths of high separation efficiency, relatively short analysis time and low consumption of chemicals, is a particularly suitable technique for use in portable analytical instrumentation. In line with the general trend in miniaturization in chemistry utilizing microfluidic chips, the main thrust of portable CE (P-CE) systems development is towards chip-based miniaturized CE. Despite this, capillary-based (non-chip) P-CE systems have certain unmatched advantages, especially in the relative simplicity of the regular cylindrical geometry of the CE capillary, maximal volume-to-surface ratio, no need to design and to fabricate a chip, the low costs of capillary compared to chip, and better performance with some detection techniques. This review presents an overview of the state of the art of P-CE and literature relevant to future developments. We pay particular attention to the development and the potential of miniaturization of functional parts for P-CE. These include components related to sample introduction, separation and detection, which are the key elements in P-CE design. The future of P-CE may be in relatively simple, rugged designs (e.g., using a short piece of capillary fixed to a chip-sized platform on which injection and detection parts can be mounted). Electrochemical detection is well suited for miniaturization, so is probably the most suitable detection technique for P-CE, but optical detection is gaining interest, especially due to miniaturized light sources (e.g., light-emitting diodes).

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“…The arrangement of AD was based on the end-column approach and has been described previously [32,33]. The carbon disc electrode was made of polymer leads (diameter 0.3 mm, hardness HB, Sakura, Japan).…”

Section: Instrumentationmentioning

confidence: 99%

Determination of unconjugated aromatic acids in urine by capillary electrophoresis with dual electrochemical detection – Potential application in fast diagnosis of phenylketonuria

Zhang

et al. 2010

Electrophoresis

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A novel method of CE coupled with dual electrochemical detection has been developed for the determination of pathological metabolites of phenylalanine in urine samples. Factors influencing the separation and detection were examined and optimized. Five aromatic acid metabolites and a major coexisting interfering compound uric acid could be well separated within 23 min at a separation voltage of 16 kV using a 35 mmol/L SDS/60 mmol/L H(3)BO(3)-Na(2)B(4)O(7) running buffer (pH 8.2). Highly linear response was obtained for these five biomarker compounds over three orders of magnitude with detection limits ranging from 6.6 to 0.064 μg/mL (S/N=3). The average recovery and RSD were within the range of 92.6-121.0 and 1.0-12.0%, respectively. The proposed method has been used to detect the unconjugated aromatic acids simultaneously in urine samples with the advantages of obtaining more information about target analytes and avoiding redundant measurements and high assay cost, thus could find potential applications involving assays of biomarker compounds for the purpose of fast diagnose of some metabolic diseases including phenylketonuria.

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Rapid determination of acetaminophen and p-aminophenol in pharmaceutical formulations using miniaturized capillary electrophoresis with amperometric detection

Cited by 146 publications

References 27 publications

Design of a New Carbon Paste Electrode Modified with TiO₂ Nanoparticles to Use in an Electrochemical Study of Codeine and Simultaneous Determination of Codeine and Acetaminophen in Human Plasma Serum Samples

Design of a New Carbon Paste Electrode Modified with TiO₂ Nanoparticles to Use in an Electrochemical Study of Codeine and Simultaneous Determination of Codeine and Acetaminophen in Human Plasma Serum Samples

Portable capillary-based (non-chip) capillary electrophoresis

Determination of unconjugated aromatic acids in urine by capillary electrophoresis with dual electrochemical detection – Potential application in fast diagnosis of phenylketonuria

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Rapid determination of acetaminophen and p-aminophenol in pharmaceutical formulations using miniaturized capillary electrophoresis with amperometric detection

Cited by 146 publications

References 27 publications

Design of a New Carbon Paste Electrode Modified with TiO2 Nanoparticles to Use in an Electrochemical Study of Codeine and Simultaneous Determination of Codeine and Acetaminophen in Human Plasma Serum Samples

Design of a New Carbon Paste Electrode Modified with TiO2 Nanoparticles to Use in an Electrochemical Study of Codeine and Simultaneous Determination of Codeine and Acetaminophen in Human Plasma Serum Samples

Portable capillary-based (non-chip) capillary electrophoresis

Determination of unconjugated aromatic acids in urine by capillary electrophoresis with dual electrochemical detection – Potential application in fast diagnosis of phenylketonuria

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Product

Resources

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Design of a New Carbon Paste Electrode Modified with TiO₂ Nanoparticles to Use in an Electrochemical Study of Codeine and Simultaneous Determination of Codeine and Acetaminophen in Human Plasma Serum Samples

Design of a New Carbon Paste Electrode Modified with TiO₂ Nanoparticles to Use in an Electrochemical Study of Codeine and Simultaneous Determination of Codeine and Acetaminophen in Human Plasma Serum Samples