Rapid Detection of Tetrodotoxin Using Surface-Enhanced Raman Spectroscopy and Fe3O4/SiO2/Au Gold/Magnetic Nanoparticles

Neng, Jing; Wang, Xujun; Jia, Kan; Sun, Peilong

doi:10.1007/s10812-018-0627-3

Cited by 7 publications

(1 citation statement)

References 21 publications

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“…SERS is a technique for enhancing Raman scattering of analyte molecules adsorbed on or in close proximity to SERS-active surfaces (i.e., rough or nanostructured metal surfaces, often classically gold, silver, or copper). This method offers high specificity and sensitivity and has been used to detect various toxins, such as saxitoxin [ 97 , 99 , 100 ], tetrodotoxin [ 102 , 103 ], domoic acid [ 97 ], okadaic acid, dinophysistoxins, yessotoxin [ 96 ], and microcystin-LR [ 98 ].…”

Section: Optical Biosensors For Detecting Aquatic Biotoxinsmentioning

confidence: 99%

Emerging Optical Materials in Sensing and Discovery of Bioactive Compounds

Vaz

Valpradinhos

Frasco

et al. 2021

Sensors

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Optical biosensors are used in numerous applications and analytical fields. Advances in these sensor platforms offer high sensitivity, selectivity, miniaturization, and real-time analysis, among many other advantages. Research into bioactive natural products serves both to protect against potentially dangerous toxic compounds and to promote pharmacological innovation in drug discovery, as these compounds have unique chemical compositions that may be characterized by greater safety and efficacy. However, conventional methods for detecting these biomolecules have drawbacks, as they are time-consuming and expensive. As an alternative, optical biosensors offer a faster, simpler, and less expensive means of detecting various biomolecules of clinical interest. In this review, an overview of recent developments in optical biosensors for the detection and monitoring of aquatic biotoxins to prevent public health risks is first provided. In addition, the advantages and applicability of these biosensors in the field of drug discovery, including high-throughput screening, are discussed. The contribution of the investigated technological advances in the timely and sensitive detection of biotoxins while deciphering the pathways to discover bioactive compounds with great health-promoting prospects is envisaged to meet the increasing demands of healthcare systems.

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