Application of surface-enhanced Raman spectroscopy in fast detection of toxic and harmful substances in food

Neng, Jing; Zhang, Qi; Sun, Peilong

doi:10.1016/j.bios.2020.112480

Cited by 118 publications

(44 citation statements)

References 114 publications

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“…[13,71] Thus, Raman is often termed as a "molecular fingerprint." RS has had a long history of analytical uses including explosives detection, [72][73][74] food technology, [75,76] and even in the analysis of artwork. [77][78][79] Berger [80] may have been the first to suggest that Raman spectroscopy could be used to analyze biofluids in a near-infrared Raman study of blood, and many studies have followed.…”

Section: Current Analysis Methodsmentioning

confidence: 99%

Methods in Raman spectroscopy for saliva studies – a review

Hardy

Kelleher

Gomes

et al. 2021

Applied Spectroscopy Reviews

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The use of Raman spectroscopy combined with saliva is an exciting emerging spectroscopy-biofluid combination. In this review, we summarize current methods employed in such studies, in particular the collection, pretreatment, and storage of saliva, as well as measurement procedures and Raman parameters used. Given the need for sensitive detection, surface-enhanced Raman methods are also surveyed, alongside chemometric techniques. A meta-analysis of variables is compiled. We observe a wide range of approaches and conclude that standardization of methods and progress to more extensive validation Raman-saliva studies is necessary. Nevertheless, the studies show tremendous promise toward the improvement of speed, diagnostic accuracy, and portable device possibilities in applications such as healthcare, law enforcement, and forensics.

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Section: Current Analysis Methodsmentioning

confidence: 99%

Methods in Raman spectroscopy for saliva studies – a review

Hardy

Kelleher

Gomes

et al. 2021

Applied Spectroscopy Reviews

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show abstract

“…However, these developed methods have not satisfied the detection limit and precision applicable to clinical practice so far. Surface-enhanced Raman spectroscopy (SERS), a common trace detection method, has been widely used in biology, medical, environmental protection, and food detection because of its advantages of high sensitivity, fast speed, and low signal interference (Liu et al, 2017;Sun et al, 2017;Neng et al, 2020;Nowicka et al, 2021). SERS enhancement effect was mainly attributed to the combination of electromagnetic mechanism (EM) and chemical mechanism (CM), which referred to the local surface plasmon resonance (LSPR) and electron transfer between adsorbed molecules and nanomaterials, respectively (Xu et al, 2018;Yu et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

SERS Based Lateral Flow Assay for Rapid and Ultrasensitive Quantification of Dual Laryngeal Squamous Cell Carcinoma-Related miRNA Biomarkers in Human Serum Using Pd-Au Core-Shell Nanorods and Catalytic Hairpin Assembly

Niu

et al. 2022

Front. Mol. Biosci.

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Non-invasive early diagnosis is of great significant in disease pathologic development and subsequent medical treatments, and microRNA (miRNA) detection has attracted critical attention in early cancer screening and diagnosis. However, it was still a challenge to report an accurate and sensitive method for the detection of miRNA during cancer development, especially in the presence of its analogs that produce intense background noise. Herein, we developed a surface-enhanced Raman scattering (SERS)–based lateral flow assay (LFA) biosensor, assisted with catalytic hairpin assembly (CHA) amplification strategy, for the dynamic monitoring of miR-106b and miR-196b, associated with laryngeal squamous cell carcinoma (LSCC). In the presence of target miRNAs, two hairpin DNAs could self-assemble into double-stranded DNA, exposing the biotin molecules modified on the surface of palladium (Pd)–gold (Au) core–shell nanorods (Pd-AuNRs). Then, the biotin molecules could be captured by the streptavidin (SA), which was fixed on the test lines (T1 line and T2 line) beforehand. The core–shell spatial structures and aggregation Pd-AuNRs generated abundant active “hot spots” on the T line, significantly amplifying the SERS signals. Using this strategy, the limits of detections were low to aM level, and the selectivity, reproducibility, and uniformity of the proposed SERS-LFA biosensor were satisfactory. Finally, this rapid analysis strategy was successfully applied to quantitatively detect the target miRNAs in clinical serum obtained from healthy subjects and patients with LSCC at different stages. The results were consistent with the quantitative real-time PCR (qRT-PCR). Thus, the CHA-assisted SERS-LFA biosensor would become a promising alternative tool for miRNAs detection, which showed a tremendous clinical application prospect in diagnosing LSCC.

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“…Surface-enhanced Raman spectroscopy (SERS) is a powerful and promising technique for identifying molecular fingerprints corresponding to molecules' vibrational energy states, enabling rapid, contactless, sensitive, label-free, and reliable chemical and biomedical analyses [1][2][3][4][5][6][7]. The amplification of Raman signals originates predominantly from an interaction of incident light with excited electron clouds of noble-metal (e.g., Ag, Au, and Cu) nanostructures (NSs), which is known as the localized surface plasmon resonance (LSPR) effect.…”

Section: Introductionmentioning

confidence: 99%

Hydrogel-Assisted 3D Volumetric Hotspot for Sensitive Detection by Surface-Enhanced Raman Spectroscopy

Lee

Kim

Yang

et al. 2022

IJMS

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Effective hotspot engineering with facile and cost-effective fabrication procedures is critical for the practical application of surface-enhanced Raman spectroscopy (SERS). We propose a SERS substrate composed of a metal film over polyimide nanopillars (MFPNs) with three-dimensional (3D) volumetric hotspots for this purpose. The 3D MFPNs were fabricated through a two-step process of maskless plasma etching and hydrogel encapsulation. The probe molecules dispersed in solution were highly concentrated in the 3D hydrogel networks, which provided a further enhancement of the SERS signals. SERS performance parameters such as the SERS enhancement factor, limit-of-detection, and signal reproducibility were investigated with Cyanine5 (Cy5) acid Raman dye solutions and were compared with those of hydrogel-free MFPNs with two-dimensional hotspots. The hydrogel-coated MFPNs enabled the reliable detection of Cy5 acid, even when the Cy5 concentration was as low as 100 pM. We believe that the 3D volumetric hotspots created by introducing a hydrogel layer onto plasmonic nanostructures demonstrate excellent potential for the sensitive and reproducible detection of toxic and hazardous molecules.

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Application of surface-enhanced Raman spectroscopy in fast detection of toxic and harmful substances in food

Cited by 118 publications

References 114 publications

Methods in Raman spectroscopy for saliva studies – a review

Methods in Raman spectroscopy for saliva studies – a review

SERS Based Lateral Flow Assay for Rapid and Ultrasensitive Quantification of Dual Laryngeal Squamous Cell Carcinoma-Related miRNA Biomarkers in Human Serum Using Pd-Au Core-Shell Nanorods and Catalytic Hairpin Assembly

Hydrogel-Assisted 3D Volumetric Hotspot for Sensitive Detection by Surface-Enhanced Raman Spectroscopy

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