Rapid detection of an Ebola biomarker with optical microring resonators

Qavi, Abraham J.; Meserve, Krista; Aman, M. Javad; Vu, Hong; Zeitlin, Larry; Dye, John M.; Froude, Jeffrey W.; Leung, Daisy W.; Yang, Lan; Holtsberg, Frederick W.; Bailey, Ryan C.; Amarasinghe, Gaya K.

doi:10.1016/j.crmeth.2022.100234

Cited by 14 publications

(21 citation statements)

References 59 publications

(73 reference statements)

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“… In a microcentrifuge tube, add PBS-BSA and thawed sample depending on which dilution is being prepared. In the corresponding study ( Qavi et al, 2022 ), each sample was prepared at 10× and 100× in a total volume of 350 μL. A minimum of 330 μL is required on the Maverick Matchbox instrument.…”

Section: Step-by-step Methods Detailsmentioning

confidence: 99%

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Detection of biomarkers for filoviral infection with a silicon photonic resonator platform

et al. 2022

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Section: Step-by-step Methods Detailsmentioning

confidence: 99%

“…This protocol is readily adaptable toward other analytes, including cytokines, chemokines, nucleic acids, and viruses. For complete details on the use and execution of this protocol, please refer to Qavi et al. (2022) .…”

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Detection of biomarkers for filoviral infection with a silicon photonic resonator platform

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“…Due to the large population of migrants, the illness has become a global public health threat. The EVD symptoms are not distinctive from those of other endemic diseases [ 33 , 34 ]. The patients first exhibit mild influenza-like symptoms, followed by shock and multiorgan failure.…”

Section: Infectious Viral Diseasesmentioning

confidence: 99%

Recent Progress on Optical Biosensors Developed for Nucleic Acid Detection Related to Infectious Viral Diseases

Ekşin

Erdem

2023

Micromachines

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Optical biosensors have many advantages over traditional analytical methods. They enable the identification of several biological and chemical compounds directly, instantly, and without the need of labels. Their benefits include excellent specificity, sensitivity, compact size, and low cost. In this review, the main focus is placed on the nucleic acid-based optical biosensor technologies, including colorimetric, fluorescence, surface plasmon resonance (SPR), Evanescent-Wave Optical, Fiber optic and bioluminescent optical fibre. The fundamentals of each type of biosensor are briefly explained, and particular emphasis has been placed on the achievements which have been gained in the last decade on the field of diagnosis of infectious viral diseases. Concluding remarks concerning the perspectives of further developments are discussed.

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“…Whispering gallery mode (WGM) microresonators have shown immense potential for the detection of various environmental targets such as temperature 1 , pressure 2 , and humidity 3 as well as biological targets [4][5][6][7] . The enormous sensitivity of the WGM platform comes from the resonators ability to trap and confine light in micron-sized circular geometries utilizing constructive interference 8 .…”

Section: Introductionmentioning

confidence: 99%

Reverse tuning of whispering gallery mode microresonators

Adolphson

Qavi²,

Shmuylovich³

et al. 2023

Optics and Biophotonics in Low-Resource Settings IX

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Whispering Gallery Mode (WGM) microresonators are a class of optical sensors with the ability to trap and confine light under optical resonance conditions. Typically, this resonance is excited inside a WGM resonator using expensive and bulky tunable diode lasers, which can be a limiting factor in low-resource settings and in developing economies. In the manuscript, we describe a method of “reverse tuning” to modify the resonance conditions, paving the way for lower cost WGM excitation and ultimately lower cost sensing. We demonstrate three different methods of reverse tuning the WGM using temperature, pressure, and refractive index in a microbubble resonator (MBR), a subclass of WGM sensors that is particularly well-suited for reverse tuning using the three aforementioned methods. By reducing the cost of the MBR platform through reverse tuning, we can make these ultra-sensitive devices more practical and accessible in low-resource settings.

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Rapid detection of an Ebola biomarker with optical microring resonators

Cited by 14 publications

References 59 publications

Detection of biomarkers for filoviral infection with a silicon photonic resonator platform

Detection of biomarkers for filoviral infection with a silicon photonic resonator platform

Recent Progress on Optical Biosensors Developed for Nucleic Acid Detection Related to Infectious Viral Diseases

Reverse tuning of whispering gallery mode microresonators

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