“…Although the renal infection with JCV is not associated with clinically apparent tissue damage, PML is a devastating central nervous system disease that mostly occurs in immunocompromised patients (5,18,22). JCV has been detected in urine and renal tissue not only of PML and immunocompromised patients but also those of the immunocompetent general population (6,8,10,12,13,14). Although there have been many reports of studies of JCV in urine and kidney tissue by DNA hybridization and/or PCR (6,4,7), histological examinations of the JCV replication site in the kidney are scarce.…”