Rapid cooling of lipid in a prilling tower

Pivette, Perrine; Faivre, Vincent; Daste, Georges; Ollivon, Michel; Lesieur, Sylviane

doi:10.1007/s10973-009-0348-1

Cited by 13 publications

(9 citation statements)

References 32 publications

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“…The sizes of the droplets and the beads are very similar (around 2 mm). No contraction was evident during gelation while a volume reduction was observed during solidification of melt droplets …”

Section: Resultsmentioning

confidence: 99%

“…No contraction was evident during gelation while a volume reduction was observed during solidification of melt droplets. [13] Figure 6 presents an example of the simulated evolution of the bead temperature and velocity as well as its drop distance versus time in the cooling column. As expected, the droplet velocity increases to reach a maximum corresponding to the terminal velocity, u t .…”

Section: Validation Model and Its Hypothesesmentioning

confidence: 99%

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Production of κ‐carrageenan beads by prilling process

et al. 2016

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The objective of this study is to prepare, evaluate, and understand carrageenan gelation. By using these properties of κ‐carrageenan, beads are created by thermal gelation. A warm κ‐carrageenan solution is extruded dropwise into a cold air column; the particles are collected. The relationship is studied between the process variables on the shape and size of κ‐carrageenan drops after gelation is established with the aid of image analysis. Thanks to these measurements, a model is developed to present satisfactory performance in industrial application. Mathematical models for κ‐carrageenan prilling, its simulated results, the parameters of equipment for the innovated process, and its application are addressed.

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Section: Resultsmentioning

confidence: 99%

Section: Validation Model and Its Hypothesesmentioning

confidence: 99%

Production of κ‐carrageenan beads by prilling process

et al. 2016

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“…The nozzle type and fluid delivery determines whether a matrix (“microsphere”) or a more core/shell-like structure (“microcapsules”) of the drug embedment is generated. Prilling is a special form of spray-congealing that delivers a product with an increased particle size of 500 to 2000 μm (“prills”) ( 120 , 157 , 361 ). For spray congealing a stable and homogenous mixed melt dispersion of the drug (and further excipients if necessary) is required.…”

Section: Selection Of Lipid-excipients and Melt Processing Techniquesmentioning

confidence: 99%

Solvent-Free Melting Techniques for the Preparation of Lipid-Based Solid Oral Formulations

2015

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Lipid excipients are applied for numerous purposes such as taste masking, controlled release, improvement of swallowability and moisture protection. Several melting techniques have evolved in the last decades. Common examples are melt coating, melt granulation and melt extrusion. The required equipment ranges from ordinary glass beakers for lab scale up to large machines such as fluid bed coaters, spray dryers or extruders. This allows for upscaling to pilot or production scale. Solvent free melt processing provides a cost-effective, time-saving and eco-friendly method for the food and pharmaceutical industries. This review intends to give a critical overview of the published literature on experiences, formulations and challenges and to show possibilities for future developments in this promising field. Moreover, it should serve as a guide for selecting the best excipients and manufacturing techniques for the development of a product with specific properties using solvent free melt processing.

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“…As lipid-based formulations can be processed using different techniques (direct compression, melt granulation, melt extrusion, molding, spray congealing/prilling, solid lipid extrusion, hot-melt coating), this paper evaluates the impact of 2 continuous processing techniques (prilling and solid lipid extrusion) on the characteristics of multiparticulate fatty acid-based formulations. In contrast to prilling where the entire lipid fraction must be molten to obtain a liquid with adequate viscosity for pumping through a calibrated nozzle to create droplets [8,9], solid lipid extrusion (SLE) operates below the melting point of the lipid component. Via a thermo-mechanical treatment at moderate pressure and temperature, the mass is sufficiently plasticized to mold it through the die of the extruder [1].…”

Section: Introductionmentioning

confidence: 99%