Rapid Communication: Genome-wide association analyses identify loci associated with colostrum production in Jersey cattle1

Kiser, J. N.; Cornmesser, M.A.; Gavin, Kevin; Hoffman, A.C.; Moore, Dale A.; Neibergs, Holly L.

doi:10.1093/jas/sky482

Cited by 3 publications

(2 citation statements)

References 38 publications

(41 reference statements)

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“…A genetic influence on colostrum quantity may also exist, as has been shown recently in Jersey cattle (Kiser et al, 2019). Interestingly, for Holstein cows, colostrum quantity does not appear to be heritable, but several aspects of colostrum quality may be (Soufleri et al, 2019).…”

Section: Discussionmentioning

confidence: 80%

Management-related factors in dry cows and their associations with colostrum quantity and quality on a large commercial dairy farm

Borchardt

Sutter

Heuwieser

et al. 2022

Journal of Dairy Science

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The objective of this observational study was to evaluate the association of management-related factors in dry cows and colostrum quantity and quality in Holstein cows on a large commercial dairy farm. This study was conducted from January 2018 to December 2020 on a commercial dairy farm in Germany, milking approximately 2,500 Holstein cows. Dairy personnel recorded colostrum quantity (n = 7,567) and evaluated colostrum quality in a subsample of animals (n = 2,600) using a digital Brix refractometer. Generalized linear mixed models were constructed to evaluate the association of management-related factors and colostrum quantity and quality. Models were run separately for primiparous or multiparous cows. The outcome variable was either colostrum quantity (kg) or quality (% Brix). Average colostrum quantity was 4.0 ± 2.5 kg, 5.1 ± 3.4 kg, and 5.5 ± 3.5 kg for cows in lactation 1, 2, and ≥3, respectively. In primiparous cows (n = 2,351), colostrum quantity was affected by month of calving (greatest in April = 4.1 kg, and lowest in November = 3.2 kg), sex of the calf (female singleton = 3.50 ± 0.26 kg; male singleton = 3.76 ± 0.27 kg; twins = 2.97 ± 0.66 kg), stillbirth (stillbirth = 3.14 ± 0.39 kg; no stillbirth = 3.68 ± 0.31 kg). In multiparous cows (n = 5,216), colostrum quantity was affected by month of calving (greatest in May = 5.5 kg, and lowest in October = 3.8 kg), calving ease (calving ease 0 = 4.23 ± 0.26 kg; score 1 = 4.77 ± 0.21 kg; score 2 = 4.98 ± 0.22 kg; score 3 = 5.30 ± 0.22 kg), sex of the calf (female singleton = 4.42 ± 0.21 kg; male singleton = 5.00 ± 0.21 kg; twins = 5.03 ± 0.30 kg), stillbirth (stillbirth = 4.24 ± 0.38 kg; no stillbirth = 5.39 ± 0.11 kg), milk yield in previous lactation (+0.1 kg increase for 1,000 kg more milk yield in previous lactation), days spent in the far-off group (0.05 ± 0.003 kg for every day), and days in the close-up pen (0.06 ± 0.010 kg for every day). Average colostrum quality was 25.1 ± 3.4% Brix, 24.7 ± 3.3% Brix, and 27.6 ± 4.4% Brix for cows in lactation 1, 2, and ≥3, respectively. In primiparous cows (n = 817), colostrum quality was affected only by month of calving. Colostrum quality in primiparous cows was greatest in December (26.8% Brix) and lowest in August (23.9% Brix). In multiparous cows (n = 1,783), colostrum quality was affected by parity (lactation 2 = 25.2 ± 2.7% Brix; lactation 3+ = 27.9 ± 2.7% Brix), month of calving (greatest in February = 27.5% Brix, and lowest in August = 25.7% Brix), milk yield in previous lactation, and colostrum quantity. We observed a seasonal pattern for colostrum quantity and quality. Future intervention studies using multiple farms need to elucidate whether management of the photoperiod or length of exposure to close-up diets, or both, can help to optimize colostrum production.

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Section: Discussionmentioning

confidence: 80%

Management-related factors in dry cows and their associations with colostrum quantity and quality on a large commercial dairy farm

Borchardt

Sutter

Heuwieser

et al. 2022

Journal of Dairy Science

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“…A study by Schennink et al ( 6 ) has revealed DGAT1 and SCD1 to be highly associated with the composition of milk-fat (long-chain fatty acid). Kiser et al ( 7 ) verified the TFAP2A gene to be related to the production of colostrum in Jersey cattle. It reported the genes CDH2 and GABRG2 to be related to the milk fat percentage and milk protein traits, respectively, in dual-purpose Xinjiang brown cattle ( 8 ).…”

Section: Introductionmentioning

confidence: 99%

Genome-wide association analysis of milk production, somatic cell score, and body conformation traits in Holstein cows

et al. 2022

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Milk production and body conformation traits are critical economic traits for dairy cows. To understand the basic genetic structure for those traits, a genome wide association study was performed on milk yield, milk fat yield, milk fat percentage, milk protein yield, milk protein percentage, somatic cell score, body form composite index, daily capacity composite index, feed, and leg conformation traits, based on the Illumina Bovine HD100k BeadChip. A total of 57, 12 and 26 SNPs were found to be related to the milk production, somatic cell score and body conformation traits in the Holstein cattle. Genes with pleiotropic effect were also found in this study. Seven significant SNPs were associated with multi-traits and were located on the PLEC, PLEKHA5, TONSL, PTGER4, and LCORL genes. In addition, some important candidate genes, like GPAT3, CEBPB, AGO2, SLC37A1, and FNDC3B, were found to participate in fat metabolism or mammary gland development. These results can be used as candidate genes for milk production, somatic cell score, and body conformation traits of Holstein cows, and are helpful for further gene function analysis to improve milk production and quality.

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Functional analysis of litter size and number of teats in pigs: From GWAS to post-GWAS

et al. 2022

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Rapid Communication: Genome-wide association analyses identify loci associated with colostrum production in Jersey cattle1

Cited by 3 publications

References 38 publications

Management-related factors in dry cows and their associations with colostrum quantity and quality on a large commercial dairy farm

Management-related factors in dry cows and their associations with colostrum quantity and quality on a large commercial dairy farm

Genome-wide association analysis of milk production, somatic cell score, and body conformation traits in Holstein cows

Functional analysis of litter size and number of teats in pigs: From GWAS to post-GWAS

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